Abstract
Immunoproliferative small intestinal disease (IPSID) is an uncommon disease of the small intestine. There is a similarity in the clinical presentations of enteropathic diseases, including celiac disease, tropical sprue, IPSID, and Whipple’s disease. A differentiation between them is based on the use of a highly specific serological test for celiac disease and specific histological characteristics. We found that IgA-anti-tissue transglutaminase antibody (IgA-tTG Ab) is falsely elevated in a subset of patients with IPSID. The levels of IgA-tTG Ab fall with the treatment of IPSID. The healthcare professional should be aware of the conditions that lead to a false-positive anti-tTG Ab. Intestinal mucosal biopsies even in the presence of anti-tTG Ab should be done in endemic regions as they provide an opportunity for making a diagnosis of alternative and uncommon diseases before the diagnosis of celiac disease.
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Conception and design of the study: Govind Makharia, Vineet Ahuja, Prasenjit Das, and Soumita Bagchi; generation, collection, assembly, and analysis and/or interpretation of data: Srikant Mohta, Ashish Agarwal, Vikas Banyal, Alka Singh, Prasenjit Das, and Soumita Bagchi; drafting or revision of the manuscript: Srikant Mohta, Ashish Agarwal, Vikas Banyal, and Alka Singh; critical revision of the article for important intellectual content: Govind Makharia, Vineet Ahuja, Prasenjit Das, and Soumita Bagchi; approval of the final version of the manuscript: all authors approved the final manuscript.
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SM, AA. VB, AS, SB, PD, VA and GM declare that they have no conflict of interest.
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Mohta, S., Agarwal, A., Banyal, V. et al. Falsely elevated anti-tissue transglutaminase antibodies in patients with immunoproliferative small intestinal diseases: A case series. Indian J Gastroenterol 42, 713–717 (2023). https://doi.org/10.1007/s12664-023-01365-5
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DOI: https://doi.org/10.1007/s12664-023-01365-5