No increased risk of perforation during colonoscopy in patients undergoing propofol versus traditional sedation: A meta-analysis
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Background and Aims
The safety of propofol sedation during colonoscopy remains unclear, and we performed a meta-analysis to assess the risk of perforation in patients undergoing propofol vs. traditional sedation.
MEDLINE, CBM, VIP, CNKI, and Wanfang databases were searched up to December 2016. Two reviewers independently assessed abstract of those searched articles. Data about perforation condition in propofol and traditional sedation groups were extracted and combined using the random effects model.
A total of 19 studies were included in the current meta-analysis. Compared to traditional sedation, propofol sedation did not increase the risk of perforation (RD = − 0.00, 95% CI − 0.00~0.00, p = 0.98; subgroup analysis: OR = 1.30, 95% CI 0.83~2.05, p = 0.25).
This meta-analysis suggested that propofol sedation did not increase the risk of perforation compared to traditional sedation during colonoscopy.
KeywordsColonoscopy Perforation Propofol sedation Risk
Compliance with ethical standards
Conflict of interest
MX, JT, JZ, HZ, JB, SZ, QW, SW, XS, DM, JL,YZ, WL, and DW declare that they have no conflicts of interests.
There are no ethical issues involved in our study for our data were based on published studies.
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