Deceased donor liver transplant: Experience from a public sector hospital in India
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Deceased donor liver transplant (DDLT) is an uncommon procedure in India. We present our experience of DDLT from a public sector teaching hospital.
A retrospective analysis of all DDLT was performed from April 2012 till September 2016. Demographics, intraoperative, donor factors, morbidity, and outcome were analyzed.
During the study period, 305 liver transplants were performed, of which 36 were DDLT (adult 32, pediatric 4; 35 grafts; 1 split). The median age was 42.5 (1–62) years; 78% were men. The median donor age was 28 (1–77) years; 72.2% were men. About 45% of organs were procured from outside of Delhi and 67% of all grafts used were marginal. Three of 38 liver grafts (7.8%) were rejected due to gross steatosis. Commonest indication was cryptogenic cirrhosis (19.4%). The median model for end-stage liver disease sodium and pediatric end-stage liver disease scores were 23.5 (9–40) and 14.5 (9–22), respectively. Median warm and cold ischemia times were 40 (23–56) and 396 (111–750) min, respectively. Major morbidity of grade III and above occurred in 63.8%. In hospital (90 days), mortality was 16.7% and there were two late deaths because of chronic rejection and biliary sepsis. The overall survival was 77.8% at median follow up of 8.6 (1–54) months.
DDLT can be performed with increasing frequency and safety in a public sector hospital. The perioperative and long-term outcomes are acceptable despite the fact that most organs were extended criteria grafts.
KeywordsDiseased donor liver transplantation Marginal grafts Public sector hospital
Compliance with ethical standards
Conflict of interest
VP, DPB, SK, KGSB, PKS, SVS, VS, CKP, and SKS declare that they have no conflicts of interest.
The study was approved by the institute’s ethics review board and is in compliance with the Helsinki Declaration, 1964, and its subsequent modifications. Standard medical care was provided to all participants. Written informed consent in a standard format was obtained from all patients who underwent surgery. Since this was a retrospective study, participation in this study did not change the consent process or decision for surgery. Formal consent for participation in this study is therefore not required.
- 2.Annual report 2015–2016. In: National Capital Region Planning Board. 2016. http://ncrpb.nic.in/pdf_files/Annual%20Report%202015-16.pdf. Accessed 15 Jan 2017
- 3.Organ Report. In: National Organ and Tissue Transplant Organization. 2014. http://www.notto.nic.in/organreport.htm. Accessed 15 Jan 2017.
- 14.Bruzzone P, Giannarelli D, Adam R, European Liver and Intestine Transplant Association, European Liver Transplant Registry. A preliminary European Liver and Intestine Transplant Association-European Liver Transplant Registry study on informed recipient consent and extended criteria liver donation. Transplant Proc. 2013;45:2613–5.CrossRefPubMedGoogle Scholar