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Lymph node micrometastasis in gallbladder cancer

  • Original Article
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Indian Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Background

Prognosis of gallbladder cancer (GBC) is grim even after curative surgery. Lymph node metastasis is the most important prognostic factor, but distant relapses occurring in their absence point towards additional factor. Lymph node micrometastasis could be one. The present study aimed to evaluate the incidence and clinical significance of lymph node micrometastasis.

Methods

This is a prospective study of patients undergoing curative surgery for GBC from 1 March 2013 to 30 April 2015, at our institute. All lymph nodes were examined with hematoxylin and eosin and immunohistochemistry against CK7. The incidence of lymph node and its relation to other clinicopathological parameters, recurrence, and survival was evaluated.

Results

Out of 589 lymph nodes retrieved from 40 patients, metastasis was seen in 13 (2.20%) nodes from 8 (20%) patients and micrometastasis in 4 (0.68%) nodes from 3 (7.5%) patients. Micrometastases were absent in pT1 tumors (0/10 in pT1 vs. 3/30 in pT2–4) and more common in patients with nodal metastasis (13% vs. 6%). Though the presence of micrometastasis would have upstaged the disease, it did not statistically relate to clinicopathological parameters, recurrence, and survival.

Conclusions

Incidence of lymph node micrometastasis in GBC was low and did not correlate with other clinicopathological parameters, recurrence, and survival.

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Authors and Affiliations

  1. Department of GI Oncosurgery, Rajiv Gandhi Cancer Institute and Research Center, Sector 5, New Delhi, 110 085, India

    Swati H. Shah, Nikhil Gupta & Shivendra Singh

  2. Department of Pathology, Rajiv Gandhi Cancer Institute and Research Center, Sector 5, New Delhi, 110 085, India

    Gurudutt Gupta & Anurag Mehta

Authors
  1. Swati H. Shah
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  2. Nikhil Gupta
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  3. Gurudutt Gupta
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  4. Anurag Mehta
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  5. Shivendra Singh
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Corresponding author

Correspondence to Shivendra Singh.

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Conflict of interest

SHS, NG, GG, AM, and SS declare that they have no competing interests.

Ethics statement

The study was performed in a manner to confirm with the Helsinki Declaration of 1975, as revised in 2000 and 2008, concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com.

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Shah, S.H., Gupta, N., Gupta, G. et al. Lymph node micrometastasis in gallbladder cancer. Indian J Gastroenterol 36, 268–274 (2017). https://doi.org/10.1007/s12664-017-0775-z

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  • DOI: https://doi.org/10.1007/s12664-017-0775-z

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