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Indian Journal of Gastroenterology

, Volume 34, Issue 3, pp 225–232 | Cite as

Dietary food groups intake and cooking methods associations with pancreatic cancer: A case–control study

  • Zeinab Ghorbani
  • Azita Hekmatdoost
  • Hassan Eini Zinab
  • Solmaz Farrokhzad
  • Roya Rahimi
  • Reza Malekzadeh
  • Akram PourshamsEmail author
Original Article

Abstract

Background

The role of dietary habits in the etiology of pancreatic cancer (PC) has not yet been well elucidated.

Aim

The aim of the present study was to examine the association of the frequency of different food groups’ intake and their cooking methods with PC risk based on a well-designed case–control study.

Methods

A case–control study including 307 PC patients and 322 controls referred to four tertiary endosonography centers was conducted from January 2011 to January 2014 to compare the frequency intake of different food items and their cooking methods between cases and controls.

Results

After adjustment for gender, age, body mass index, years of education, diabetes and alcohol history, smoking status, and opium use, a significant direct relationship was observed between PC risk and intake frequency (time/week) of bread (OR = 1.50; 95 % CI 1.05–2.13; p-value 0.024), rice (OR = 2.10; 95 % CI 1.15–3.82; p for trend 0.034), and red meat (OR = 2.25; 95 % CI 1.22–4.14; p for trend 0.033) (time/day), when comparing the highest category of intake frequency with the lowest, while increasing frequency of fish consumption was associated with a lower risk of PC (OR = 0.93; 95 % CI0.59–1.47; p for trend 0.009). Increasing consumption of barbecuing red meat and deep fried vegetables was associated with 67 % and 70 % increased risk of PC (p-value 0.025 and 0.006, respectively).

Conclusion

Our results indicate that increased frequency of intake of bread, rice, and red meat (especially barbecued) and deep fried vegetables can aggregate PC risk, while increased frequency of fish consumption can protect against PC. However, more studies are still needed.

Keywords

Case–control study Cooking methods Dietary factors Pancreatic neoplasms 

Notes

Conflict of interest

ZGh, AH, HEZ, SF, RR, RM, and AP declare no conflict of interest related to this work.

Ethics statement

The authors declare that the survey was performed in a manner that conforms to the Declaration of Helsinki of 1975, as revised in 2000 and 2008, concerning human and animal rights and that the authors followed the policy concerning informed consent wherever applicable as shown in www.Springer.com.

References

  1. 1.
    Yadav D, Lowenfels AB. The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144:1252–61.PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917.PubMedCrossRefGoogle Scholar
  3. 3.
    Greer JB, Brand RE. New developments in pancreatic cancer. Curr Gastroenterol Rep. 2011;13:131–9.PubMedCrossRefGoogle Scholar
  4. 4.
    Cappellani A, Cavallaro A, Di Vita M, et al. Diet and pancreatic cancer: many questions with few certainties. Eur Rev Med Pharmacol Sci. 2012;16:192–206.PubMedGoogle Scholar
  5. 5.
    Pandol S, Gukovskaya A, Edderkaoui M, Dawson D, Eibl G, Lugea A. Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. J Gastroenterol Hepatol. 2012;27 Suppl 2:127–34.PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.PubMedCrossRefGoogle Scholar
  7. 7.
    Bao Y, Hu FB, Giovannucci EL, et al. Nut consumption and risk of pancreatic cancer in women. Br J Cancer. 2013;109:2911–6.PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Hart AR, Kennedy H, Harvey I. Pancreatic cancer: a review of the evidence on causation. Clin Gastroenterol Hepatol. 2008;6:275–82.PubMedCrossRefGoogle Scholar
  9. 9.
    Anderson LN, Cotterchio M, Gallinger S. Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada. Cancer Causes Control. 2009;20:825–34.PubMedCentralPubMedCrossRefGoogle Scholar
  10. 10.
    Stolzenberg-Solomon RZ, Adams K, Leitzmann M, et al. Adiposity, physical activity, and pancreatic cancer in the National Institutes of Health-AARP Diet and Health Cohort. Am J Epidemiol. 2008;167:586–97.PubMedCrossRefGoogle Scholar
  11. 11.
    Grote VA, Rohrmann S, Nieters A, et al. Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Diabetologia. 2011;54:3037–46.PubMedCrossRefGoogle Scholar
  12. 12.
    Silverman DT, Schiffman M, Everhart J, et al. Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer. 1999;80:1830–7.PubMedCentralPubMedCrossRefGoogle Scholar
  13. 13.
    Chang MC, Wong JM, Chang YT. Screening and early detection of pancreatic cancer in high risk population. World J Gastroenterol. 2014;20:2358–64.PubMedCentralPubMedCrossRefGoogle Scholar
  14. 14.
    Zhang J, Dhakal IB, Gross MD, et al. Physical activity, diet, and pancreatic cancer: a population-based, case–control study in Minnesota. Nutr Cancer. 2009;61:457–65.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Rubin MS, Clouston S, Link BG. A fundamental cause approach to the study of disparities in lung cancer and pancreatic cancer mortality in the United States. Soc Sci Med. 2014;100:54–61.PubMedCrossRefGoogle Scholar
  16. 16.
    Farrokhzad S, Nedjat S, Kamangar F, Kamali M, Malekzadeh R, Pourshams A. Validity and reliability of a questionnaire designed to assess risk factors of pancreatic cancer in iran. Arch Iran Med. 2014;17:102–5.PubMedGoogle Scholar
  17. 17.
    Azar M, Sarkisian E. Food Composition Table of Iran. Tehran: National Nutrition and Food Research Institute: Shahid Beheshti University Press. 1980.Google Scholar
  18. 18.
    Yener Y, Kalipci E, Oztas H, Aydin AD, Yildiz H. Possible neoplastic effects of acrylamide on rat exocrine pancreas. Biotech Histochem. 2013;88:47–53.PubMedCrossRefGoogle Scholar
  19. 19.
    Abedi-Ardekani B, Kamangar F, Hewitt SM, et al. Polycyclic aromatic hydrocarbon exposure in oesophageal tissue and risk of oesophageal squamous cell carcinoma in north-eastern Iran. Gut. 2010;59:1178–83.PubMedCentralPubMedCrossRefGoogle Scholar
  20. 20.
    Etemadi A, Islami F, Phillips DH, et al. Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype. Int J Cancer. 2013;132:2738–47.PubMedCentralPubMedCrossRefGoogle Scholar
  21. 21.
    Islami F, Boffetta P, van Schooten FJ, et al. Exposure to polycyclic aromatic hydrocarbons among never smokers in Golestan Province, Iran, an area of high incidence of esophageal cancer—a cross-sectional study with repeated measurement of urinary 1-OHPG in two seasons. Front Oncol. 2012;2:14.PubMedCentralPubMedCrossRefGoogle Scholar
  22. 22.
    Kamangar F, Strickland PT, Pourshams A, et al. High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran. Anticancer Res. 2005;25:425–8.PubMedGoogle Scholar
  23. 23.
    Marjani HA, Biramijamal F, Rakhshani N, Hossein-Nezhad A, Malekzadeh R. Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case–control study from Iran. Genet Mol Res. 2010;9:239–49.PubMedCrossRefGoogle Scholar
  24. 24.
    Roshandel G, Semnani S, Malekzadeh R, Dawsey SM. Polycyclic aromatic hydrocarbons and esophageal squamous cell carcinoma. Arch Iran Med. 2012;15:713–22.PubMedGoogle Scholar
  25. 25.
    Anderson KE, Sinha R, Kulldorff M, et al. Meat intake and cooking techniques: associations with pancreatic cancer. Mutat Res. 2002;506–507:225–31.PubMedCrossRefGoogle Scholar
  26. 26.
    Larsson SC, Wolk A. Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies. Br J Cancer. 2012;106:603–7.PubMedCentralPubMedCrossRefGoogle Scholar
  27. 27.
    Heinen MM, Verhage BA, Goldbohm RA, van den Brandt PA. Meat and fat intake and pancreatic cancer risk in the Netherlands Cohort study. Int J Cancer. 2009;125:1118–26.PubMedCrossRefGoogle Scholar
  28. 28.
    Anderson KE, Mongin SJ, Sinha R, et al. Pancreatic cancer risk: associations with meat-derived carcinogen intake in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort. Mol Carcinog. 2012;51:128–37.PubMedCentralPubMedCrossRefGoogle Scholar
  29. 29.
    Michaud DS. Dietary meat, dairy products, fat, and cholesterol and pancreatic cancer risk in a prospective study. Am J Epidemiol. 2003;157:1115–25.PubMedCrossRefGoogle Scholar
  30. 30.
    Stolzenberg-Solomon RZ, Cross AJ, Silverman DT, et al. Meat and meat-mutagen intake and pancreatic cancer risk in the NIH-AARP cohort. Cancer Epidemiol Biomarkers Prev. 2007;16:2664–75.PubMedCrossRefGoogle Scholar
  31. 31.
    Larsson SC, Hakanson N, Permert J, Wolk A. Meat, fish, poultry and egg consumption in relation to risk of pancreatic cancer: a prospective study. Int J Cancer. 2006;118:2866–70.PubMedCrossRefGoogle Scholar
  32. 32.
    Qin B, Xun P, He K. Fish or long-chain (n-3) PUFA intake is not associated with pancreatic cancer risk in a meta-analysis and systematic review. J Nutr. 2012;142:1067–73.PubMedCentralPubMedCrossRefGoogle Scholar
  33. 33.
    He K, Xun P, Brasky TM, Gammon MD, Stevens J, White E. Types of fish consumed and fish preparation methods in relation to pancreatic cancer incidence: the VITAL Cohort Study. Am J Epidemiol. 2013;177:152–60.PubMedCentralPubMedCrossRefGoogle Scholar
  34. 34.
    Rohrmann S, Linseisen J, Nothlings U, et al. Meat and fish consumption and risk of pancreatic cancer: results from the European prospective investigation into cancer and nutrition. Int J Cancer. 2013;132:617–24.PubMedCrossRefGoogle Scholar
  35. 35.
    Larsson SC, Hakansson N, Naslund I, Bergkvist L, Wolk A. Fruit and vegetable consumption in relation to pancreatic cancer risk: a prospective study. Cancer Epidemiol Biomarkers Prev. 2006;15:301–5.PubMedCrossRefGoogle Scholar
  36. 36.
    Ghadirian P, Nkondjock A. Consumption of food groups and the risk of pancreatic cancer: a case–control study. J Gastrointest Cancer. 2010;41:121–9.PubMedCrossRefGoogle Scholar
  37. 37.
    Chan JM, Wang F, Holly EA. Vegetable and fruit intake and pancreatic cancer in a population-based case–control study in the San Francisco bay area. Cancer Epidemiol Biomarkers Prev. 2005;14:2093–7.PubMedCrossRefGoogle Scholar
  38. 38.
    Nothlings U, Wilkens LR, Murphy SP, Hankin JH, Henderson BE, Kolonel LN. Vegetable intake and pancreatic cancer risk: the multiethnic cohort study. Am J Epidemiol. 2007;165:138–47.PubMedCrossRefGoogle Scholar
  39. 39.
    Vrieling A, Verhage BA, van Duijnhoven FJ, et al. Fruit and vegetable consumption and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2009;124:1926–34.PubMedCrossRefGoogle Scholar
  40. 40.
    Jansen RJ, Robinson DP, Stolzenberg-Solomon RZ, et al. Fruit and vegetable consumption is inversely associated with having pancreatic cancer. Cancer Causes Control. 2011;22:1613–25.PubMedCentralPubMedCrossRefGoogle Scholar
  41. 41.
    Koushik A, Spiegelman D, Albanes D, et al. Intake of fruits and vegetables and risk of pancreatic cancer in a pooled analysis of 14 cohort studies. Am J Epidemiol. 2012;176:373–86.PubMedCentralPubMedCrossRefGoogle Scholar
  42. 42.
    Genkinger JM, Wang M, Li R, et al. Dairy products and pancreatic cancer risk: a pooled analysis of 14 cohort studies. Ann Oncol. 2014;25:1106–15.PubMedCentralPubMedCrossRefGoogle Scholar
  43. 43.
    Jansen RJ, Robinson DP, Frank RD, et al. Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case–control study. Int J Cancer. 2014;134:1935–46.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Indian Society of Gastroenterology 2015

Authors and Affiliations

  • Zeinab Ghorbani
    • 1
    • 2
  • Azita Hekmatdoost
    • 1
  • Hassan Eini Zinab
    • 3
  • Solmaz Farrokhzad
    • 2
  • Roya Rahimi
    • 2
  • Reza Malekzadeh
    • 2
  • Akram Pourshams
    • 2
    Email author
  1. 1.Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food TechnologyResearch Institute Shahid Beheshti University of Medical ScienceTehranIran
  2. 2.Digestive Disease Research Institute, Shariati HospitalTehran University of Medical SciencesTehranIran
  3. 3.Department of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food TechnologyResearch Institute Shahid Beheshti University of Medical ScienceTehranIran

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