Abstract
Objective
The aim of the study was to investigate the plasma levels of matrix metalloproteinase-9 (MMP-9), transforming growth factor-β 1 (TGF-β1), and tumor necrosis factor-α (TNF-α) in chronic pancreatitis (CP).
Methods
Blood samples were obtained from 71 patients with CP and 100 control subjects, and plasma levels of MMP-9, TGF-β1, and TNF-α were determined by enzyme-linked immunosorbent assay.
Results
The plasma levels of MMP-9 (18.3 ± 3.0 ng/mL, p < 0.0001), TGF-β1 (215.4 ± 178.1 ng/mL, p = 0.0301), and TNF-α (111.2 ± 69.3 ng/mL, p < 0.001) were significantly elevated in CP compared to the control group.
Conclusion
The role of elevated plasma MMP-9, TGF-β1, and TNF-α in CP requires further evaluation.
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References
Goodman AJ, Gress FG. The endoscopic management of pain in chronic pancreatitis. Gastroenterol Res Pract. 2012;2012:1–5.
Lindley KJ. Chronic pancreatitis. Indian J Pediatr. 2006;73:907–12.
Werb Z. ECM and cell surface proteolysis regulating cellular ecology. Cell. 1997;91:439–42.
Massagué J. The transforming growth factor-beta family. Annu Rev Cell Biol. 1990;6:597–641.
Norman J. The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg. 1998;175:76–83.
Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 2002;50:535–41.
Nagase H, Woessner JF. Matrix metalloproteinases. J Biol Chem. 1999;274:21491–4.
Aysel K, Mehmet I, Şeval A, Seyfettin K, Engin U, Ali U. Serum TNF-alpha levels in acute and chronic pancreatitis. Eur J Gen Med. 2009;6:103–7.
Ebihara I, Nakamura T, Shimada N, Koide H. Increased plasma matrix metalloproteinase-9 concentrations precede development of microalbuminuria in non-insulin-dependent diabetes mellitus. Am J Kidney Dis. 1998;32:544–50.
Yokota T, Denham W, Murayama K, Pelham C, Joehl R, Bell RH Jr. Pancreatic stellate cell activation and MMP production in experimental pancreatic fibrosis. J Surg Res. 2002;104:106–11.
Bartram U, Speer CP. The role of transforming growth factor in lung development and disease. Chest. 2004;125:754–65.
Menke A, Adler G. TGFβ-induced fibrogenesis of the pancreas. Int J Gastrointest Cancer. 2002;31:41–6.
Phan SH. Fibroblast phenotypes in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2003;29:S87–92.
Szuster-Ciesielska A, Daniluk J, Kandefer-Zerszen M. Serum levels of cytokines in alcoholic liver cirrhosis and pancreatitis. Arch Immunol Ther Exp (Warsz). 2000;48:301–17.
Zhukov NA, Shirinskaia NV, Dolgikh TI, Akhmedov VA. Dynamics of expression of cytokines and lactoferrin in patients with chronic alcohol pancreatitis and chronic relapsing pancreatitis. Eksp Klin Gastroenterol. 2003;5:67–71.
Nakao A. Is TGF-beta1 the key to suppression of human asthma? Trends Immunol. 2001;22:115–8.
Howat WJ, Holgate ST, Lackie PM. TGF-beta isoform release and activation during in vitro bronchial epithelial wound repair. Am J Physiol Lung Cell Mol Physiol. 2002;282:L115–23.
O’Kane S, Ferguson MW. Transforming growth factors and wound healing. Int J Biochem Cell Biol. 1997;29:63–78.
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Manjari, K.S., Jyothy, A., Vidyasagar, A. et al. Matrix metalloproteinase-9, transforming growth factor-β1, and tumor necrosis factor-α plasma levels in chronic pancreatitis. Indian J Gastroenterol 32, 103–107 (2013). https://doi.org/10.1007/s12664-012-0299-5
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DOI: https://doi.org/10.1007/s12664-012-0299-5