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Gastrointestinal stromal tumors: a clinicopathological and immunohistochemical study of 121 cases

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Abstract

Background

Primary mesenchymal tumors of the gastrointestinal tract are a heterogeneous group of tumors with a wide clinical spectrum, of which gastrointestinal stromal tumors (GIST) typically occur in middle-aged to older individuals. This study evaluated the clinicopathological and morphological features of GIST of the intestinal tract.

Methods

The study included 108 gastrointestinal and 13 extra-gastrointestinal stromal tumors involving the mesentry and retroperitoneum between January 1989 and July 2007. Immunohistochemical expression of CD117, CD34, SMA, Desmin, S100, and Ki-67 were studied.

Results

GIST comprised 108 of 120 (90%) of the mesenchymal tumors. The tumor was located in the stomach in the majority (55%) of patients followed by small intestine (30%), retroperitoneum (7%) and the colorectum (4%). There was a significant correlation between tumor size and mitotic index, with larger tumors having higher mitotic index (p < 0.001). Mitotic index per 5 mm2 correlated with high cellularity (p < 0.001), presence of necrosis (p < 0.001) and presence of mucosal invasion (p = 0.01). Expression of CD117 was seen in 94%, CD34 in 59%, SMA in 41%, S-100 in 33%, and desmin in 4% of tumors.

Conclusion

We found GIST to be the most common mesenchymal tumor of the gastrointestinal tract.

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Authors and Affiliations

  1. Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, Uttar Pradesh, India

    Mukul Vij, Vinita Agrawal & Rakesh Pandey

  2. Department of Surgical Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, Uttar Pradesh, India

    Ashok Kumar

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  1. Mukul Vij
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  2. Vinita Agrawal
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  3. Ashok Kumar
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  4. Rakesh Pandey
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Correspondence to Vinita Agrawal.

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Vij, M., Agrawal, V., Kumar, A. et al. Gastrointestinal stromal tumors: a clinicopathological and immunohistochemical study of 121 cases. Indian J Gastroenterol 29, 231–236 (2010). https://doi.org/10.1007/s12664-010-0079-z

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  • DOI: https://doi.org/10.1007/s12664-010-0079-z

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