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Chronic atrophic antral gastritis and risk of metaplasia and dysplasia in an area with low prevalence of Helicobacter pylori

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Abstract

Introduction

The Northeastern region of Peninsular Malaysia is an area with exceptionally low prevalence for Helicobacter pylori infection. The risk of intestinal metaplasia and dysplasia in patients with chronic atrophic gastritis (CAG) and its association with Helicobacter pylori is unknown in this region.

Methods

This was a cross-sectional study on gastric biopsies from 234 consecutive patients (mean age 53.5 [14.8] years) who underwent upper gastrointestinal endoscopy between January 2006 and December 2006.

Results

There were 137 (59%) men and 185 (79%) Malay patients. Among 234 biopsies, CAG was found in 99 and non-atrophic gastritis in 135. Intestinal metaplasia and dysplasia were detected in 8 and 6 atrophic gastritis biopsies, respectively, and in 10 and 3 of non-atrophic gastritis biopsies, respectively. H. pylori were detected in 16 (9 Malays, 7 non- Malays) biopsies (p=0.024); intestinal metaplasia was detected in 4 biopsies (p=0.3) and dysplasia in 5 biopsies (p=0.3). Of the 218 biopsies negative for H. pylori, intestinal metaplasia was found in 14 and dysplasia in 4. The risk of intestinal metaplasia as well as dysplasia was associated with presence of H. pylori infection (p=0.029 and p<0.001 respectively).

Conclusion

Even in a setting of low prevalence of H. pylori, intestinal metaplasia and dysplasia were significantly associated with H. pylori infection. The frequency of intestinal metaplasia and dysplasia was similar different between biopsies with atrophic gastritis and non-atrophic gastritis.

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Authors and Affiliations

  1. Department of Medicine, University Sains Malaysia, Kelantan, Malaysia

    Lee Yeong Yeh & Ventakesh R. Naik

  2. Pantai Medical Centre, Kuala Lumpur, Malaysia

    Mahendra Raj

  3. Department of Surgery, University Sains Malaysia, Kelantan, Malaysia

    Syed Abdul Aziz

  4. Department of Pathology, University Sains Malaysia, Kelantan, Malaysia

    Nor Hayati Othman & Samarendra Singh Mutum

Authors
  1. Lee Yeong Yeh
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  2. Mahendra Raj
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  3. Syed Hassan
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  4. Syed Abdul Aziz
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  5. Nor Hayati Othman
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  6. Samarendra Singh Mutum
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  7. Ventakesh R. Naik
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Correspondence to Lee Yeong Yeh.

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Yeh, L.Y., Raj, M., Hassan, S. et al. Chronic atrophic antral gastritis and risk of metaplasia and dysplasia in an area with low prevalence of Helicobacter pylori . Indian J Gastroenterol 28, 49–52 (2009). https://doi.org/10.1007/s12664-009-0017-0

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  • DOI: https://doi.org/10.1007/s12664-009-0017-0

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