Skip to main content
SpringerLink
Log in

Tale of Ameloblastoma – An Experience Spanning Two Decades

  • CLINICAL PAPER
  • Published:
Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Introduction

Despite being a benign pathology, ameloblastoma is considered to be locally-aggressive and has a high recurrence-rate. The following study describes the experience in a tertiary care hospital to manage ameloblastoma using treatment modalities based on the site of occurrence and histologic-type and to evaluate recurrence in long term.

Material and methods

In this 21-year-long retrospective study, 92 patients were followed-up for a minimum period of 5-years (range 5–21 years) to assess the clinical and demographic characteristics, treatment-procedure performed, and outcomes including the recurrence-rate associated with different treatment-strategies for treating ameloblastoma.

Results

Out of 92 cases, 90 had mandibular involvement, with the most frequent site being Body (B), and Angle and Ramus (AR) region. The most prevalent histological-subtype was plexiform ameloblastoma. Five cases had mixed histopathologic-presentations in which more than one histological variant was found simultaneously. Segmental resection with reconstruction using a reconstruction plate was the most commonly employed surgical procedure for all histologic types. One case of plexiform ameloblastoma that underwent marginal resection presented with a recurrence at 189 months.

Conclusions

Based on the observed results, it is concluded that adequate surgical planning along with long-term follow-up may provide the desired results and reduce the rate of recurrence.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Buchner A, Merrell PW, Carpenter WM (2006) Relative frequency of central odontogenic tumors: a study of 1,088 cases from northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg 64:1343–1352. https://doi.org/10.1016/j.joms.2006.05.019

    Article  PubMed  Google Scholar 

  2. Rastogi V, Pandilwar PK, Maitra S (2010) Ameloblastoma: an evidence based study. J Maxillofac Oral Surg 9:173–177. https://doi.org/10.1007/s12663-010-0060-5

    Article  PubMed  PubMed Central  Google Scholar 

  3. Junquera L, Ascani G, Vicente JC, García-Consuegra L, Roig P (2003) Ameloblastoma revisited. Ann Otol Rhinol Laryngol 112:1034–1039. https://doi.org/10.1177/000348940311201207

    Article  PubMed  Google Scholar 

  4. Masthan KMK, Anitha N, Krupaa J, Manikkam S (2015) Ameloblastoma. J Pharm Bioallied Sci 7:S167–S170. https://doi.org/10.4103/0975-7406.155891

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rizzitelli A, Smoll NR, Chae MP, Rozen WM, Hunter-Smith DJ (2015) Incidence and overall survival of malignant ameloblastoma. PLoS ONE 10:1–9. https://doi.org/10.1371/journal.pone.0117789

    Article  CAS  Google Scholar 

  6. Etetafia MO, Arisi AA, Omoregie OF (2014) Giant ameloblastoma mortality; a consequence of ignorance, poverty and fear. BMJ Case Rep. https://doi.org/10.1136/bcr-2013-201251

    Article  PubMed  PubMed Central  Google Scholar 

  7. Nastri AL, Wiesenfeld D, Radden BG, Eveson J, Scully C (1995) Maxillary ameloblastoma: a retrospective study of 13 cases. Br J Oral Maxillofac Surg 33:28–32. https://doi.org/10.1016/0266-4356(95)90082-9

    Article  CAS  PubMed  Google Scholar 

  8. Kyriazis AP, Karkazis GC, Kyriazis AA (1971) Maxillary ameloblastoma with intracerebral extension: report of a case. Oral Surg Oral Med Oral Pathol 32:582–587. https://doi.org/10.1016/0030-4220(71)90323-9

    Article  CAS  PubMed  Google Scholar 

  9. Wright JM, Vered M (2017) Update from the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol 11:68–77. https://doi.org/10.1007/s12105-017-0794-1

    Article  PubMed  PubMed Central  Google Scholar 

  10. Soluk-Tekkeşin M, Wright JM (2018) The world health organization classification of odontogenic lesions: a summary of the changes of the 2017 (4th) edition. Turk Patoloji Derg 34:1–18. https://doi.org/10.5146/tjpath.2017.01410

    Article  CAS  Google Scholar 

  11. Pogrel MA, Montes DM (2009) Is there a role for enucleation in the management of ameloblastoma? Int J Oral Maxillofac Surg 38:807–812. https://doi.org/10.1016/j.ijom.2009.02.018

    Article  CAS  PubMed  Google Scholar 

  12. Reichart PA, Philipsen HP, Sonner S (1995) Ameloblastoma: biological profile of 3677 cases. Eur J Cancer Part B Oral Oncol 31:86–99. https://doi.org/10.1016/0964-1955(94)00037-5

    Article  Google Scholar 

  13. Olaitan AA, Arole G, Adekeye EO (1998) Recurrent ameloblastoma of the jaws: a follow-up study. Int J Oral Maxillofac Surg 27:456–460. https://doi.org/10.1016/s0901-5027(98)80037-4

    Article  CAS  PubMed  Google Scholar 

  14. Sun ZJ, Wu YR, Cheng N, Zwahlen RA, Zhao YF (2009) Desmoplastic ameloblastoma–a review. Oral Oncol 45:752–759. https://doi.org/10.1016/j.oraloncology.2009.01.016

    Article  PubMed  PubMed Central  Google Scholar 

  15. Adekeye EO, Lavery KMC (1986) Recurrent ameloblastoma of the maxillo-facial region: clinical features and treatment. J Maxillofac Surg 14:153–157. https://doi.org/10.1016/S0301-0503(86)80282-X

    Article  CAS  PubMed  Google Scholar 

  16. Hendra FN, Natsir Kalla DS, Van Cann EM, de Vet HCW, Helder MN, Forouzanfar T (2019) Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta-analysis. Oral Dis 25:1683–1696. https://doi.org/10.1111/odi.13014

    Article  PubMed  Google Scholar 

  17. Gardner DG (1984) A pathologist’s approach to the treatment of ameloblastoma. J Oral Maxillofac Surg 42:161–166. https://doi.org/10.1016/S0278-2391(84)80026-9

    Article  CAS  PubMed  Google Scholar 

  18. Vayvada H, Mola F, Menderes A, Yilmaz M (2006) Surgical management of ameloblastoma in the mandible: segmental mandibulectomy and immediate reconstruction with free fibula or deep circumflex iliac artery flap (evaluation of the long-term esthetic and functional results). J Oral Maxillofac Surg 64:1532–1539. https://doi.org/10.1016/j.joms.2005.11.065

    Article  PubMed  Google Scholar 

  19. Pappalardo M, Tsao CK, Tsang ML, Zheng J, Chang YM, Tsai CY (2018) Long-term outcome of patients with or without osseointegrated implants after resection of mandibular ameloblastoma and reconstruction with vascularized bone graft: functional assessment and quality of life. J Plast Reconstr Aesthetic Surg 71:1076–1085. https://doi.org/10.1016/j.bjps.2018.03.008

    Article  Google Scholar 

  20. Laborde A, Nicot R, Wojcik T, Ferri J, Raoul G (2017) Ameloblastoma of the jaws: management and recurrence rate. Eur Ann Otorhinolaryngol Head Neck Dis 134:7–11. https://doi.org/10.1016/j.anorl.2016.09.004

    Article  CAS  PubMed  Google Scholar 

  21. Sharma P, Mohanty S, Chaudhary Z, Joshi H (2015) Non-microvascular management of mandibular ameloblastoma: a retrospective study of 15 years. Int J Oral Maxillofac Surg 44:e143. https://doi.org/10.1016/j.ijom.2015.08.802

    Article  Google Scholar 

  22. Nakamura N, Mitsuyasu T, Higuchi Y, Sandra F, Ohishi M (2001) Growth characteristics of ameloblastoma involving the inferior alveolar nerve: a clinical and histopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:557–562. https://doi.org/10.1067/moe.2001.113110

    Article  CAS  PubMed  Google Scholar 

  23. Figueiredo NR, Dinkar AD, Meena M, Satoskar S, Khorate M (2014) Ameloblastoma: a clinicoradiographic and histopathologic correlation of 11 cases seen in Goa during 2008–2012. Contemp Clin Dent 5:160–165. https://doi.org/10.4103/0976-237X.132305

    Article  PubMed  PubMed Central  Google Scholar 

  24. Dunfee BL, Sakai O, Pistey R, Gohel A (2006) Radiologic and pathologic characteristics of benign and malignant lesions of the mandible. Radiographics 26:1751–1768. https://doi.org/10.1148/rg.266055189

    Article  PubMed  Google Scholar 

  25. Chaitanya B, Chhaparwal Y, Pai KM, Kudva A, Cariappa KM, Acharya S (2016) Hybrid ameloblastoma: an amalgam of rare and conventional ameloblastoma. Contemp Clin Dent 7:90–94. https://doi.org/10.4103/0976-237X.177089

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Shaik JA, Reddy RK (2017) Review article prevention and treatment of white spot lesions in orthodontic patients. Contemp Clin Dent 8:11–19. https://doi.org/10.4103/ccd.ccd

    Article  Google Scholar 

  27. Ueno S, Mushimoto K, Shirasu R (1989) Prognostic evaluation of ameloblastoma based on histologic and radiographic typing. J Oral Maxillofac Surg 47:11–15. https://doi.org/10.1016/0278-2391(89)90116-X

    Article  CAS  PubMed  Google Scholar 

  28. Qiao X, Shi J, Liu J, Liu J, Guo Y, Zhong M (2021) Recurrence rates of intraosseous ameloblastoma cases with conservative or aggressive treatment: a systematic review and meta-analysis. Front Oncol 11:1720. https://doi.org/10.3389/fonc.2021.647200

    Article  Google Scholar 

  29. Iwase M, Fukuoka A, Tanaka Y, Saida N, Onaka E, Bando S et al (2017) Hybrid desmoplastic/follicular ameloblastoma of the mandible: a case report and review of the literature. Case Rep Pathol 2017:1–6. https://doi.org/10.1155/2017/7031414

    Article  Google Scholar 

  30. Hertog D, Bloemena E, Aartman IHA, Van-der-Waal I (2012) Histopathology of ameloblastoma of the jaws; some critical observations based on a 40 years single institution experience. Med Oral Patol Oral Cir Bucal. https://doi.org/10.4317/medoral.18006

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We acknowledge the support provided by the Department of Oral Pathology and Microbiology and the Department of Prosthodontics for assessment and treatment planning.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Maulana Azad Institute of Dental Sciences, Bahadur Shah Zafar Marg, New Delhi, 110002, India

    Sujata Mohanty, Mithilesh Kadanthode, Anjali Verma & Neeraj Bansal

  2. Department of Oral and Maxillofacial Pathology, Maulana Azad Institute of Dental Sciences, Bahadur Shah Zafar Marg, New Delhi, 110002, India

    Aadithya B. Urs & Priya Kumar

Authors
  1. Sujata Mohanty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mithilesh Kadanthode
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anjali Verma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Aadithya B. Urs
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Neeraj Bansal
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Priya Kumar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sujata Mohanty.

Ethics declarations

Conflict of interest

None.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 33 KB)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mohanty, S., Kadanthode, M., Verma, A. et al. Tale of Ameloblastoma – An Experience Spanning Two Decades. J. Maxillofac. Oral Surg. (2024). https://doi.org/10.1007/s12663-024-02197-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12663-024-02197-2

Keywords

Search

Navigation