Abstract
Introduction
Complications in patients post-COVID 19 viral infection are many and include maxillary mucormycosis. Mucormycosis is usually treated with radical maxillary resection and debridement of involved structures along with the use of anti-fungal agents. The extensive removal of hard and soft tissue results in severe functional and cosmetic defects. Rehabilitation of these patients requires implant-supported prosthesis for adequate retention. However, the lack of adequate bone in the maxilla precludes the use of conventional dental implants alone for dental rehabilitation and often requires additional zygomatic implants. These implants can usually support a removable over denture prosthesis.
Case Reports
This article describes two cases, wherein patients had had an extensive resection and their removable obturator prosthesis were not retentive enough. These patients were successfully rehabilitated using zygomatic implants supported removable prosthesis. Both the patients were satisfied with the cosmetic and functional rehabilitation. At the end of one year follow up, the implants and prosthesis were stable.
Conclusion
Zygomatic implants are a useful tool to rehabilitate patients who have undergone maxillary resection for management of post-COVID maxillary mucormycosis defect (PCMMD).
References
Garg D, Muthu V, Sehgal IS, Ramachandran R, Kaur H, Bhalla A et al (2021) Coronavirus disease (Covid-19) associated mucormycosis (CAM): case report and systematic review of literature. Mycopathologia 186:289–98
Kumar M, Sarma DK, Shubham S, Kumawat M, Verma V, Singh B et al (2021) Mucormycosis in COVID-19 pandemic: risk factors and linkages. Curr Res Microb Sci. 2:100057
Raut A, Huy NT (2021) Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave? Lancet Respir Med 9(8):e77. https://doi.org/10.1016/S2213-2600(21)00265-4
Singh AK, Singh R, Joshi SR, Misra A (2021) Mucormycosis in COVID-19: a systematic review of cases reported worldwide and in India. Diabetes Metab Syndr 15:102146
Ahmed E, Abou-Bakr A, Hussein RR, El-Gawish AA, Ras A, bakr E, Ghalwash DM (2021) Oral mucormycosisin post-COVID-19 patients: a case series. Oral Dis. https://doi.org/10.1111/ODI.13973
Jain A, Taneja S (2021) Post-COVID fungal infections of maxillofacial region: a systematic review. Oral Maxillofac Surg. https://doi.org/10.1007/S10006-021-01010-5
Samaranayake LP, Leung WK, Jin L (2009) Oral mucosal fungal infections. Periodontol 2000 49:39–59
Spellberg B, Edwards J Jr, Ibrahim A (2005) Novel perspectives on mucormycosis:pathophysiology, presentation, and management. Clin Microbiol Rev 18:556–569
Skiada A, Lass-Floerl C, Klimko N, Ibrahim A, Roilides E, Petrikkos G (2018) Challenges in the diagnosis and treatment of mucormycosis. Med Mycol 56:93–101. https://doi.org/10.1093/mmy/myx101
Kurrasch M, Beumer J, Kagawa T (1982) Mucormycosis: oral and prosthodontic implications. A report of 14 patients. J Prosthet Dent 47:422–9
Deokar G, Yeshwante B, Baig N, Jadhav V, Patil R (2021) Post COVID-19 mucormycosis (black fungus) and its prosthodontic considerations. Indian J Contemp Dent. 9(2):6–13
Beumer J, Curtis T, Marunick M (1996) Maxillofacial rehabilitation: prosthodontic and surgical considerations. IshiyakuEuroAmerica Inc, St. Louis, pp 113–223
Parel SM, Brånemark PI, Ohrnell LO, Svensson B (2001) Remote implant anchorage for the rehabilitation of maxillary defects. J Prosthet Dent 86:377–381
Bidra AS, May GW, Tharp GE, Chambers MS (2013) Pterygoid implants for maxillofacial rehabilitation of a patient with a bilateral maxillectomydefect. J Oral Implantol. 39:91–7
Kondaka S, Singh VD, Vadlamudi C, Bathala LR (2022) Prosthetic rehabilitation of untailored defects using patient-specific implants. Dent Res J (Isfahan) 19:83
Manekar VS, Datarkar AN, Ghormode A, Daware S, Pandilwar P, Sapkal P (2023) Comparison of two types of patient specific implants (PSI) and quad zygoma implant (QZI) for rehabilitation of post-COVID maxillary mucormycosis defect (PCMMD): finite element analysis. J Maxillofac Oral Surg. 22(3):688–694. https://doi.org/10.1007/s12663-023-01950-3
Aparicio C, Brånemark PI, Keller EE, Olive J (1993) Reconstruction of the premaxilla with autogenous iliac bone in combination with osseointegrated implants. Int J Oral Maxillofac Implants 8:61–67
Brånemark P-I (1998) Surgery and fixture installation. Zygomaticus fixture clinical procedures, Nobel Biocare AB, Göteborg, p 1
Butterworth CJ (2018) Immediately loaded zygomatic implant retained maxillary obturator used in the management of a patient following total maxillectomy. Int J Head Neck Surg 9(2):94–100
Brown JS, Rogers SN, McNally DN, Boyle M (2000) A modified classification for the maxillectomy defect. Head Neck 22(1):17–26
Skiada A, Pavleas I, Drogari-Apiranthitou M (2020) Epidemiology and diagnosis of mucormycosis: an update. J Fungi 6(4):265
Kumar L, Verma A, Pal US, Mattoo K, Algarni YA, Bin Hassan SA, Baba SM, Jeri SY, Khateeb SU (2023) Influence of prosthodontic rehabilitation using zygomatic implants in COVID 19 related mucormycosis (rhino-orbital-cerebral) maxillectomy patients upon post-operative stress, anxiety and functional impairment: a prospective cohort study. Clin Interv Aging 1(18):1201–1219
Keyf F (2001) Obturator prostheses for hemimaxillectomy patients. J Oral Rehabil 28:821–829
Vega LG, Gielincki W, Fernandes RP (2013) Zygoma implants reconstruction of acquired maxillary bony defects. Oral Maxillofac Surg Clin North Am 25(2):223–239
Reinbold C, Derder M, Hivelin M, Ozil C, Al Hindi A, Lantieri L (2016) Using free flaps for reconstruction during infections by mucormycosis: a case report and a structured review of the literature. Ann Chir Plast Esthet 61(2):153–161. https://doi.org/10.1016/j.anplas.2015.05.006
Brånemark PI, Gröndahl K, Öhrnell LO et al (2004) Zygoma fixture in the management of advanced atrophy of the maxilla: technique and long-term results. Scand J Plast Reconstr Surg Hand Surg 38(2):70–85
Davó R, David L (2021) Quad zygoma protocol. Atlas Oral Maxillofac Surg Clin North Am 29(2):243–251
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Rajan, G., Obla Ramesh, A., Krishnamurthy, S. et al. Zygomatic Implant-based Rehabilitation in Post-COVID Maxillary Mucormycosis Defects: A Case Series. J. Maxillofac. Oral Surg. (2024). https://doi.org/10.1007/s12663-024-02130-7
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DOI: https://doi.org/10.1007/s12663-024-02130-7