Abstract
Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign vascular non-neoplastic lesion that is characterized by papillary proliferation of vascular endothelial cells. Masson first described this lesion in 1923, and since then, it has been named Masson’s tumor, intravascular angiomatosis, Masson’s lesion, Masson’s pseudoangiosarcoma, Masson’s hemangioma, and vegetant intravascular hemangioendothelioma. The term IPEH is currently the most illustrative and the most frequently used in the literature. This lesion seems to occur in any blood vessel in the body, but it is more likely to be observed in the skin and subcutaneous tissues of the head and neck region, fingers, and trunk. Mandibular involvement is rare. IPEH’s etiology remains unknown. Histopathological examination reveals a reactive proliferation of endothelial cells organized in minor papillary assemblies with hypocellular and hyalinized centers and arising from an organized thrombus. The appropriate treatment for IPEH is the excision with healthy margins; prognosis is good, with rare recurrences that may occur when the lesion is incompletely excised. The aim of the present article is to report and discuss the clinical, histopathological, immunohistochemical, and therapeutic issues of a case of IPEH of the mandible in a 66-year-old woman.
References
Xu SS, Li D (2014) Radiological imaging of florid intravascular papillary endothelial hyperplasia in the mandibule: case report and literature review. Clin Imaging. 38(3):364–366
Komori A, Koike M, Kingo T, Azuma T, Yoshinari M, Inaba H et al (1984) Centralintravascular papillary endothelial hyperplasia of the mandible. Virchows Arch 403:453–459
Soares AB, Altemani A, Furuse C, Demasi AP, Gati C, Nunes N et al (2008) Intravascularpapillary endothelial hyperplasia: report of 2 cases and immunohistochem-ical study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106:708–711
Sarode GS, Sarode SC, Karmarkar SP (2014) Oral intravascular papillary endothelialhyperplasia (masson’s tumor): a review of literature. J Oral Maxillofac Surg 26:73–79
Williams HJ, Wake MJ, John PR (2002) Intraosseous haemangioma of the mandible: acase report. Pediatr Radiol 32:605–608
Campos MS, Garcia-Rejas RA, Pinto DS Jr, de Sousa SC, Nunes FD (2009) Intravascularpapillary endothelial hyperplasia: report of 4 cases with immunohistochemicalfindings. Med Oral Pathol Oral Cir Bucal 14:e506–e509
Cheng NC, Lai DM, Hsie MH, Liao SL, Chen YB (2006) Intraosseous hemangiomas ofthe facial bone. Plast Reconstr Surg 117:2366–2372
Tanio S, Okamoto A, Majbauddin A, Sonoda M, Kodani I, Doi R, Ryoke K (2016) Intravascular papillary endothelial hyperplasia associated with hemangioma of the mandible: a rare case report. J Oral Maxillofac Surg, Med, Pathol 28:55–60
de Castro MS, de Carli ML, Giudice FS et al (2017) Oral intravascular papillary endothelial hyperplasia: case report and review of literature. J Oral Maxillofac Surg, Med, Pathol 29(2):173–179
Eguchi T, Nakaoka K, Basugi A, Arai G, Hamada Y (2020) Intravascular papillary endothelial hyperplasia in the mandible: a case report. J Int Med Res 48(11):300060520972900
Mirmohammadsadeghi H, Mashhadiabbas F, Latifi F (2019) Huge central intravascular papillary endothelial hyperplasia of the mandible: a case report and review of the literature. J Korean Assoc Oral Maxillofac Surg 45(4):180–185
Shrestha KK, Jha AK, Joshi RR, Rijal AS, Dhungana A, Maharjan S (2018) Masson’s hemangioma of the cheek: a case report. Indian J Otolaryngol Head Neck Surg 70(2):321–324
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MM contributed to conceptualization; MM and PB provided methodology; AG and MM performed validation; PB and MF carried out formal analysis; PB and MB performed data curation; PB performed writing—original draft preparation; PB, MF, and MM performed writing—review and editing; MB and MM performed supervision. All authors have read and agreed to the published version of the manuscript.
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Boffano, P., Brucoli, M., Ferrillo, M. et al. Intravascular Papillary Endothelial Hyperplasia of the Mandible in a 66 Year-Old Woman. J. Maxillofac. Oral Surg. (2024). https://doi.org/10.1007/s12663-023-02102-3
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DOI: https://doi.org/10.1007/s12663-023-02102-3