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A Comparative Clinicopathological Study of Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG)

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Objective

To evaluate and compare the clinicopathological features of giant cell tumour (GCT), central giant cell granuloma (CGCG) and peripheral giant cell granuloma (PGCG).

Material and methods

From 2006 to 2016, all histopathologically diagnosed cases of GCT were retrieved from the Department of Pathology, T.N.M.C, Mumbai and CGCG and PGCG were retrieved from the Department of Oral Pathology, Nair Hospital Dental College, Mumbai. Statistical analysis of the clinicopathological features was done using SPSS v 21.0, IBM. Intergroup comparison of all variables was done using t test for two groups, whereas, Kruskal–Wallis test and one-way ANOVA were done for more than two groups.

Results

Twelve cases of GCT, 31 cases of CGCG and 39 cases of PGCG were reported over 11 years. The mean age of occurrence for GCT, CGCG and PGCG was 30.41 years, 27.69 years and 34.03 years, respectively. GCT was seen in long bones and CGCG and PGCG showed mandible predilection. Histologically, GCT showed evenly distributed giant cells with aggregated nuclei, whereas CGCG and PGCG showed aggregated giant cells with evenly distributed nuclei. The mean value of the number of giant cells and nuclei within giant cells was maximum in GCT (27.33, 33.50) followed by CGCG (23.56, 15.51) and PGCG (21.45, 11.32).

Conclusion

The clinicopathological differences between GCT, CGCG and PGCG suggest that each one of these entities represent biologically different lesions.

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Funding

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Authors and Affiliations

  1. Department of Pathology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Mumbai, India

    Saurabh R. Nagar

  2. HomiBhabha National Institute, Mumbai, 400012, India

    Saurabh R. Nagar

  3. Department of Oral Pathology & Microbiology, Government Dental College & Hospital, Mumbai, Maharashtra, 400001, India

    Saurabh R. Nagar

  4. Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, 400008, India

    Shivani Bansal & Rajiv S. Desai

  5. Department of Pathology, BYL Nair Charitable Hospital and T.N Medical College, Mumbai, 400008, India

    Kusum Jashnani

Authors
  1. Saurabh R. Nagar
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  2. Shivani Bansal
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  3. Kusum Jashnani
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  4. Rajiv S. Desai
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Contributions

SRN, SB, RSD contributed to study concepts; SRN, SB contributed to study design; SRN, SB, RSD, KJ contributed to data Acquisition.

Corresponding author

Correspondence to Shivani Bansal.

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All the authors declare no conflict of interest related to this study.

Ethical approval

Approval of the Institutional Ethical Committee (IEC), NHDC (Nair Hospital Dental College), Mumbai; was obtained before starting the study.

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Informed consent has been obtained from all the study participants.

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Nagar, S.R., Bansal, S., Jashnani, K. et al. A Comparative Clinicopathological Study of Giant Cell Tumour (GCT), Central Giant Cell Granuloma (CGCG) and Peripheral Giant Cell Granuloma (PGCG). J. Maxillofac. Oral Surg. 22, 485–501 (2023). https://doi.org/10.1007/s12663-022-01724-3

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  • DOI: https://doi.org/10.1007/s12663-022-01724-3

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