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Prognostic Value of Lymph Node Density Compared to Pre-operative Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients with Tongue Squamous Cell Carcinoma

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Abstract

Background

We aimed to investigate the prognostic significance of lymph node density (LND), and pre-operative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for outcome measuring in tongue squamous cell carcinoma (TSCC)’ patients.

Methods

A total of 129 patients who underwent surgery for TSCC were enrolled in this retrospective study. LND and pre-operative NLR and PLR were used as outcome measures and their correlations with different clinicopathological features were examined.

Results

The cutoff values for NLR, PLR, and LND were obtained 1.21, 97.81, and 0.02, respectively, by receiver operating characteristic (ROC) curve approach. Only LND was found to be significantly associated with decreased overall survival (HR = 4.24; 95% CI 1.49–12.10; P = 0.007) and disease-free survival (HR = 3.48; 95% CI 1.43–8.45; P = 0.006) both in univariate and multivariate analyzes.

Conclusion

Based on the findings, the LND has superiority over pre-operative NLR and PLR in predicting outcomes for the patients with TSCC.

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Acknowledgements

This work was carried out at Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran and financially was supported by Tehran University of Medical Sciences, Tehran, Iran [Grant NO# 97-02-51-39760]. The authors would like to give special thanks to the all staffs of Cancer Institute and Medical University of Tehran.

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Authors and Affiliations

  1. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mona Khazravi, Mohammad Shirkhoda & Amirmohsen Jalaeefar

  2. Department of Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hana Saffar

  3. Cancer Research Center of Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mona Khazravi & Amirmohsen Jalaeefar

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  1. Mona Khazravi
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Correspondence to Amirmohsen Jalaeefar.

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Khazravi, M., Shirkhoda, M., Saffar, H. et al. Prognostic Value of Lymph Node Density Compared to Pre-operative Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients with Tongue Squamous Cell Carcinoma. J. Maxillofac. Oral Surg. 21, 845–855 (2022). https://doi.org/10.1007/s12663-021-01524-1

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