Skip to main content

Advertisement

Log in

A Comparative Study Between Ondansetron and Gabapentin for Prevention of Postoperative Nausea and Vomiting Following Maxillofacial Surgery

  • Original Article
  • Published:
Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Background and Aim

Gabapentin is an antiepileptic drug with antiemetic properties. We evaluated prophylactic oral gabapentin as compared with ondansetron for postoperative nausea and vomiting (PONV) in patients undergoing maxillo facial surgery.

Settings and Design

A double-blind, randomized study in a teaching hospital.

Materials and Methods

Seventy patients of ASA physical status I and II, scheduled to undergo maxillofacial surgery, were randomly assigned into two groups to receive 300 mg gabapentin or 8 mg ondansetron 1 h before surgery. Standard anaesthesia technique was used in all patients. Students’ t test for difference of means between two groups was used for continuous variables. Chi square or Fisher’s exact test was used for comparing proportion between two groups. Kaplan–Meier survival analysis was performed to compare the time to event observed between ondansetron and gabapentin groups. Log-rank test was performed to detect statistical significance of time to events between two groups.

Results

There was no significant difference in incidence of PONV between two groups within 2 h postoperatively. No incidence of PONV was observed in gabapentin group within 2–24 h as compared to ondansetron group in which PONV was observed in five cases.

Conclusion

Gabapentin effectively suppresses PONV in maxillo facial surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Myles PS, Williams DL, Hendrata M, Anderson H, Weeks AM (2000) Patient satisfaction after anaesthesia and surgery: results of a prospective survey of 10,811 patients. Br J Anaesth 84:6–10

    Article  CAS  Google Scholar 

  2. Macario A, Weinger M, Carney S, Kim A (1999) Which clinical anesthesia outcomes are important to avoid? Perspective of patients. Anesth Analg 89:652–658

    CAS  PubMed  Google Scholar 

  3. Wagner DS, Yap JM, Bradley KM, Voepel-Lewis T (2007) Assessing parents preferences for the avoidance of undesirable anesthesia side effects in their children undergoing surgical procedures. Paediatr Anaesth 17:1035–1042

    PubMed  Google Scholar 

  4. Habib AS, Chen YT, Taguchi A, Hu XH, Gan TJ (2006) Postoperative nausea and vomiting following inpatient surgeries in a teaching hospital: a retrospective database analysis. Curr Med Res Opin 22:1093–1099

    Article  Google Scholar 

  5. Talesh KT, Motamedi MH, Kahnamouii S (2011) Comparison of ondansetron and metoclopramide antiemetic prophylaxis in maxillofacial surgery patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:275–277

    Article  Google Scholar 

  6. Savant K, Khandeparker RVS, Berwal V, Khandeparker PV, Jain H (2016) Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study. J Korean Assoc Oral Maxillofac Surg 42:84–89

    Article  Google Scholar 

  7. Achuthan S, Singh I, Varthya SB, Srinivasan A, Chakrabarti A, Hota D (2015) Gabapentin prophylaxis for postoperative nausea and vomiting in abdominal surgeries: a quantitative analysis of evidence from randomized controlled clinical trials. Br J Anaesth 114:588–597

    Article  CAS  Google Scholar 

  8. Franck M, Radtke FM, Apfel CC et al (2010) Documentation of postoperative nausea and vomiting in routine clinical practice. J Int Med Res 38:1034–1041

    Article  CAS  Google Scholar 

  9. Chang CY, Challa CK, Shah J, Eloy JD (2014) Gabapentin in acute postoperative pain management. Biomed Res Int 2014:631756

    PubMed  PubMed Central  Google Scholar 

  10. Grant MC, Lee H, Page AJ, Hobson D, Wick E, Wu CL (2016) The effect of preoperative gabapentin on postoperative nausea and vomiting: a meta-analysis. Anesth Analg 122(4):976–985

    Article  CAS  Google Scholar 

  11. Jahromi HE, Gholami M, Rezaei F (2013) A randomized double-blinded placebo controlled study of four interventions for the prevention of postoperative nausea and vomiting in maxillofacial trauma surgery. J Craniofac Surg 24:e623–e627

    Article  Google Scholar 

  12. Apfel CC, Roewer N, Korttila K (2002) How to study postoperative nausea and vomiting. Acta Anaesthesiol Scand 46:921–928

    Article  CAS  Google Scholar 

  13. Kim KM, Huh J, Lee SK, Park EY, Lee JM (2017) Combination of gabapentin and ramosetron for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a prospective randomized comparative study. BMC Anesthesiol 17:65

    Article  Google Scholar 

  14. Guttuso T Jr, Robinson IK, Amankwah KS (2010) Gabapentin use in hyperemesis gravidarum: a pilot study. Early Hum Dev 86:65–66

    Article  CAS  Google Scholar 

  15. Luo ZD, Chaplan SR, Higuera ES, Sorkin LS, Stauderman KA, Williams ME, Yaksh TL (2001) Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci 21:1868–1875

    Article  CAS  Google Scholar 

  16. Davies A, Kadurin I, Alvarez-Laviada A et al (2010) The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function. Proc Natl Acad Sci USA 107:1654–1659

    Article  CAS  Google Scholar 

  17. Gurnett CA, De Waard M, Campbell KP (1996) Dual function of the voltage-dependent Ca2 + channel alpha 2 delta subunit in current stimulation and subunit interaction. Neuron 16:431–440

    Article  CAS  Google Scholar 

  18. Felix R, Gurnett CA, De Waard M, Campbell KP (1997) Dissection of functional domains of the voltage-dependent Ca2 + channel alpha2delta subunit. J Neurosci 17:6884–6891

    Article  CAS  Google Scholar 

  19. Guttuso T Jr (2014) Gabapentin’s anti-nausea and anti-emetic effects: a review. Exp Brain Res 232:2535–2539

    Article  CAS  Google Scholar 

  20. Dirks J, Fredensborg BB, Christensen D, Fomsgaard JS, Flyger H, Dahl JB (2002) A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 97:560–564

    Article  CAS  Google Scholar 

  21. Doha NM, Rady A, Samia R, Azab E (2010) Preoperative use of gabapentin decreases the anesthetic and analgesic requirements in patients undergoing radical mastectomy. Egypt J Anaesth 26:287–291

    Article  Google Scholar 

  22. Rose MA, Kam PC (2002) Gabapentin: pharmacology, its use in pain management. Anaesthesia 57:451–462

    Article  CAS  Google Scholar 

  23. Nelson R, Tse B, Edwards S (2005) Systematic review of prophylactic nasogastric decompression after abdominal operations. Br J Surg 92:673–680

    Article  CAS  Google Scholar 

  24. Aspinall RL, Goodman NW (1995) Denial of effective treatment and poor quality of clinical information in placebo controlled trials of ondansetron for postoperative nausea and vomiting: a review of published trials [see comments]. BMJ 311:844–846

    Article  CAS  Google Scholar 

  25. Le May S, Hardy JF, Taillefer MC, Dupuis G (2001) Patient satisfaction with anesthesia services. Can J Anaesth 48:153–161

    Article  Google Scholar 

Download references

Funding

None declared.

Author information

Authors and Affiliations

Authors

Contributions

PD was involved in concept, data collection, literature search, writing and reviewing manuscript. GKT contributed to design, supervision, writing and reviewing manuscript. AR was involved in design, data analysis, writing and reviewing manuscript.

Corresponding author

Correspondence to Preksha Dubey.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflict of interest.

Ethics Approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of ITS Dental College (Date Jan 27, 2018/No.IEC/OS/01/18).

Consent for Publication

Informed consent obtained.

Availability of Data and Material

Available.

Code Availability

Available.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dubey, P., Thapliyal, G.K. & Ranjan, A. A Comparative Study Between Ondansetron and Gabapentin for Prevention of Postoperative Nausea and Vomiting Following Maxillofacial Surgery. J. Maxillofac. Oral Surg. 19, 616–623 (2020). https://doi.org/10.1007/s12663-020-01366-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12663-020-01366-3

Keywords

Navigation