Abstract
Aims and Objectives
Oral cancer is one of the most common cancers in Indian subcontinent with alveobuccal complex as most common cancer sub site. Cancers of Alveobuccal complex provides maximum challenge and management guidelines are not clear. The aim of the present study is to provide comprehensive demographic, clinical and treatment outcome data of alveobuccal squamous cell carcinoma (SCC) patients treated at a tertiary care cancer center in North India.
Materials and Methods
An analysis of prospectively maintained database in department of surgical oncology at Dr BRA-IRCH, AIIMS, Delhi, India was performed. All alveobuccal cancer patients who had undergone surgery from 1995 to 2010 were included for analysis.
Results
A total of 353 patients were included for analysis. Mean age was 49.75 years (SD ±12.04) with male and female ratio of 4:1. Composite resection without mandible was done in 25 % patients and 75 % underwent mandibular resection. Neck dissection was performed in 347 patients. Nodal deposits were identified in 124 (35.73 %) neck dissection specimens. Margin negative resection was performed in 89.5 % cases. After a median follow up of 30 months, 87 (24.64 %) patients developed disease relapse and 25 (7.08 %) patients developed second primaries. Overall 5-year disease free survival (DFS) was 57.65 % and 5 year overall survival (OS) was 59.86 %.
Conclusion
Among Indian oral cancer patients alveobuccal complex is most common sub site. Majority presents in locally advanced stage and reasonably good outcomes can be achieved with quality control surgery and judicious use of radiotherapy.
Similar content being viewed by others
References
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M et al (2015) Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012: Globocan 2012. Int J Cancer 136(5):E359–E386
Dayal PK, Mani NJ, Bhargava K (1978) Prevalence of oral cancer and precancerous lesions in “pan”/’supari’ chewers. Indian J Public Health 22(3):234–245
Malaovalla AM, Silverman S, Mani NJ, Bilimoria KF, Smith LW (1976) Oral cancer in 57,518 industrial workers of Gujarat, India: a prevalence and followup study. Cancer 37(4):1882–1886
Dhar PK, Rao TR, Sreekumaran Nair N, Mohan S, Chandra S, Bhat KR et al (2000) Identification of risk factors for specific subsites within the oral and oropharyngeal region—a study of 647 cancer patients. Indian J Cancer 37(2–3):114–122
ICD-10 Version:2015 [Internet]. [cited 2016 Mar 16]. http://apps.who.int/classifications/icd10/browse/2015/en#/II
Rodgers GK, Myers EN (1988) Surgical management of the mass in the buccal space. Laryngoscope 98(7):749–753
Shaw RJ, McGlashan G, Woolgar JA, Lowe D, Brown JS, Vaughan ED et al (2009) Prognostic importance of site in squamous cell carcinoma of the buccal mucosa. Br J Oral Maxillofac Surg 47(5):356–359
Choi K-K, Kim M-J, Yun P-Y, Lee J-H, Moon H-S, Lee T-R et al (2006) Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults. Oral Oncol 42(2):208–217
Ghoshal S, Mallick I, Panda N, Sharma SC (2006) Carcinoma of the buccal mucosa: analysis of clinical presentation, outcome and prognostic factors. Oral Oncol 42(5):533–539
Chhetri DK, Rawnsley JD, Calcaterra TC (2000) Carcinoma of the buccal mucosa. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 123(5):566–571
Jan J-C, Hsu W-H, Liu S-A, Wong Y-K, Poon C-K, Jiang R-S et al (2011) Prognostic factors in patients with buccal squamous cell carcinoma: 10-year experience. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 69(2):396–404
Dixit S, Vyas RK, Toparani RB, Baboo HA, Patel DD (1998) Surgery versus surgery and postoperative radiotherapy in squamous cell carcinoma of the buccal mucosa: a comparative study. Ann Surg Oncol 5(6):502–510
Lubek JE, Dyalram D, Perera EHK, Liu X, Ord RA (2013) A retrospective analysis of squamous carcinoma of the buccal mucosa: an aggressive subsite within the oral cavity. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 71(6):1126–1131
Bachar G, Goldstein DP, Barker E, Lea J, O’Sullivan B, Brown DH et al (2012) Squamous cell carcinoma of the buccal mucosa: outcomes of treatment in the modern era. Laryngoscope 122(7):1552–1557
Deo SVS, Purkayastha J, Das DK, Kar M, Srinivas G, Asthana S et al (2003) Reconstruction of complex oral defects using bi-paddle pectoralis major flap—technical modifications and outcome in 54 cancer patients. Indian J Otolaryngol Head Neck Surg 55(1):5–9
Diaz EM, Holsinger FC, Zuniga ER, Roberts DB, Sorensen DM (2003) Squamous cell carcinoma of the buccal mucosa: one institution’s experience with 119 previously untreated patients. Head Neck 25(4):267–273
Fang Q-G, Shi S, Li Z-N, Zhang X, Liua F-Y, Xu Z-F et al (2013) Squamous cell carcinoma of the buccal mucosa: analysis of clinical presentation, outcome and prognostic factors. Mol Clin Oncol 1(3):531–534
Bloom ND, Spiro RH (1980) Carcinoma of the cheek mucosa. A retrospective analysis. Am J Surg 140(4):556–559
Niu LX, Feng Z, Li JN, Li CZ, Peng X, Guo CB (2014) Prognostic factors of squamous cell carcinoma of the buccal mucosa: a retrospective study of 168 cases in North China. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg 72(11):2344–2350
Deo SVS, Shukla NK, Jha D, Khanna P, Pandit A, Thulkar S (2012) Are we over-treating neck in buccal & alveolo-buccal cancers: experience from a tertiary cancer care center. Indian J Surg Oncol 3(4):272–275
D’Cruz AK, Vaish R, Kapre N, Dandekar M, Gupta S, Hawaldar R et al (2015) Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med 373(6):521–529
Coppen C, de Wilde PCM, Pop LA, van den Hoogen FJA, Merkx MAW (2006) Treatment results of patients with a squamous cell carcinoma of the buccal mucosa. Oral Oncol 42(8):795–799
Paymaster JC (1956) Cancer of the buccal mucosa; a clinical study of 650 cases in Indian patients. Cancer 9(3):431–435
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Nootan kumar Shukla, S V Suryanarayana Deo, Ashish Jakhetiya, Manjunath NML, Vishnubhatla Sreenivas, Sanjay Thulkar, Suman Bhasker and Atul Sharma declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Shukla, N.k., Deo, S.V.S., Jakhetiya, A. et al. Clinical Spectrum, Treatment and Relapse Patterns in 353 Patients with Squamous Cell Carcinoma of the Alveobuccal Complex Treated with a Curative Intent: A Retrospective Study. J. Maxillofac. Oral Surg. 17, 24–31 (2018). https://doi.org/10.1007/s12663-016-0970-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12663-016-0970-y