Mucoepidermoid Carcinoma of the Salivary Glands: Survival and Prognostic Factors
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The aim of this study was to establish global survival rates and potential prognostic factors for mucoepidermoid carcinoma (MC) of the salivary glands in patients diagnosed at the Dr. Eduardo Cáceres Graziani National Institute for Neoplastic Diseases (INEN), Lima, Peru, between 2002 and 2012.
Materials and Methods
This was an observational, analytical and longitudinal (information reconstructed in time) retrospective cohort study. Data were obtained from clinical records and used to determine the overall survival (OS) rate at 2 and 5 years, and the individual percentage survival for each prognostic factor using the actuarial technique. We also performed univariate analysis for each possible prognostic factor using log-rank analysis, and multivariate analysis using Cox’s regression model. The study was approved by the institutional review board at Dr. Eduardo Caceres Graziani INEN and conducted in accordance with the 1964 Declaration of Helsinki. For this type of study formal consent was not required.
The OS rate of the 51 patients enrolled in the study was 81 % at 2 years and 78 % at 5 years. In the multivariate analysis, the equation that best explained the survival result contained the variable, clinical stage (p = 0.063).
The results revealed the importance of clinical stage regarding the survival of patients with a primary diagnosis of MC of the salivary glands.
KeywordsMucoepidermoid carcinoma Survival Salivary gland Neoplasms
This study was self-funded.
Compliance with Ethical Standards
Conflict of interest
The authors declare that they have no competing interests.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at Dr. Eduardo Caceres Graziani INEN (protocol: INEN 13:27) and conducted in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
For this type of study formal consent is not required to be retrospective.
- 2.Ellis GL, Auclair PL (2008) Atlas of tumor pathology: Tumors of the major salivary glands. 4º Series, Fascicle 9. Washington DC: Armed Forces Institute of Pathology (AFIP)Google Scholar
- 3.Barnes L, Evenson JW, Reichart P, Sidransky D (2005) World Health Organization classification of tumours. Pathology and genetics of Head and Neck Tumours. IARC Press, Lyon (France)Google Scholar
- 34.Villavicencio-Ayala B, Reséndiz-Colosia JA, Labastida-Almendaro S, Torres-Núñe MG, Peña-Torres LM, Gallegos-Hernández JF (2006) Factores pronósticos en carcinoma mucoepidermoide de cabeza y cuello. Cir Cir 76:109–117Google Scholar
- 35.Schwarz S, Stiegler C, Müller M, Ettl T, Brockhoff G, Zenk J et al (2011) Salivary gland mucoepidermoid carcinoma is a clinically, morphologically and genetically heterogeneous entity: a clinicopathological study of 40 cases with emphasis on grading, histological variants and presence of the t(11;19) translocation. Histopathology 58:557–570CrossRefPubMedGoogle Scholar
- 37.Spiro RH (2001) Factors affecting survival in salivary gland cancers. In: McGurk M, Renehan A (eds) Controversies in the management of salivary gland disease. Oxford University Press, Oxford, pp 143–150Google Scholar