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Wound Healing Concepts in Clinical Practice of OMFS

  • Review Paper
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Abstract

Background

Wound healing is a complex and dynamic process and a thorough knowledge of the basics of physiology of wound healing is a must to implement principles of chronic wound care. Understanding wound healing at multiple levels—biochemical, physiologic, cellular and molecular provides the surgeon with a framework for basing clinical decisions aimed at optimizing the healing response.

Objective

This review article describes the classification of wounds and aims to highlight the fundamentals of wound repair, enumerating the dressings used commonly and also, the newer concepts of wound healing.

Materials and methods

Search engines and medical databases were tapped to gather information on the subject. Search words employed were “Wounds”, “wounds in OSMF”, “Wound healing”, “Repair”, “Dressings in OMFS”.

Results

The search resulted in total of 153 articles which we reviewed to add to the literature the concepts of wound healing and to throw some light on recent advances in wound care.

Conclusions

Wound healing remains a challenging clinical problem and correct, efficient wound management is essential to positively influence the wound healing course and reduce potential complications.

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References

  1. Mehra R (2002) Historical survey of wound healing. Bull Indian Inst Hist Med Hyderabad 32(2):159–175

    PubMed  Google Scholar 

  2. Kerstein MD (1997) The scientific basis of healing. Adv Wound Care 10(3):30–36

    CAS  PubMed  Google Scholar 

  3. Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pecoraro RE, Rodeheaver G et al (1994) Definitions and guidelines for assessment of wounds and evaluation of healing. Arch Dermatol 130:489–493

    Article  CAS  PubMed  Google Scholar 

  4. Robson MC, Steed DL, Franz MG (2001) Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg 38:72–140

    Article  CAS  PubMed  Google Scholar 

  5. Natarajan S, Williamson D, Stiltz AJ, Harding K (2000) Advances in wound care and healing technology. Am J Clin Dermatol 1:269–275

    Article  CAS  PubMed  Google Scholar 

  6. Alonso JE, Lee J, Burgess AR, Browner BD (1996) The management of complex orthopaedic injuries. Surg Clin N Am 76:879–903

    Article  CAS  PubMed  Google Scholar 

  7. Traversa B, Sussman G (2001) The role of growth factors, cytokines and proteases in wound management. Primary Intent 9(4):161–167

    Google Scholar 

  8. Sabiston DC (1991) Chap 10: Wound healing: biologic and clinical features. In: Sabiston DC (ed) Textbook of surgery, 14th edn. WB Saunders, Philadelphia. ISBN: 0-7216-3492-3

    Google Scholar 

  9. Sharma M, Khajja BS, Jha S, Mathur GK, Mathur VN (2011) Forensic interpretation of injuries/wounds found on the human body. J Punjab Acad Forensic Med Toxicol 11(2):105–109

    Google Scholar 

  10. Bischoff M, Kinzl L, Schmelz A (1999) The complicated wound. Unfallchirurg 102:797–804

    Article  CAS  PubMed  Google Scholar 

  11. Degreef H (1998) How to heal a wound fast. Dermatol Clin 16:365–375

    Article  CAS  PubMed  Google Scholar 

  12. Attinger CE, Janis JE, Steinberg J, Schwartz J, Al-Attar A, Couch K (2006) Clinical approach to wound debridement and wound bed preparation including the use of dressings and wound healing adjuvants. Plast Reconstr Surg 117(7 Suppl):72S–109S

    Article  CAS  PubMed  Google Scholar 

  13. CCHCS care guide: wound and skin ulcer management. Nov 2012

  14. Chard R (2008) Wound classifications. Clinical issues. AORN J 88(1):108–109

    Google Scholar 

  15. Miloro M, Ghali GE, Larsen PE, Waite PD (2004) Chapter 1 Wound healing. In: Shetty V, Bertolami CN (eds) Peterson’s principles of oral and maxillofacial surgery, 2nd edn. BC Decker, Hamilton. ISBN: 1-55009-234-0

    Google Scholar 

  16. Kumar V, Abbas AK, Fausto N (2004) Robbins and Cotron Pathologic basis of disease, 7th edn. Saunders, Philadelphia, PA. ISBN: 0808923021

    Google Scholar 

  17. Rajagopal KS (2008) Manipal manual of surgery, 2nd edn. CBS Pullisher, New Delhi. ISBN: 978-81-239-1649-1

    Google Scholar 

  18. Peterson AS (2010) The “golden period” for wound repair. J Lanc Gen Hosp 5(4):134–135

    Google Scholar 

  19. Diegelmann RF, Evans MC (2004) Wound healing: an overview of acute fibrotic and delayed healing. Front Biosci 9:283–289

    Article  CAS  PubMed  Google Scholar 

  20. Werner S, Grose R (2003) Regulation of wound healing by growth factors and cytokines. Physiol Rev 83:835–870

    CAS  PubMed  Google Scholar 

  21. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341:738–746

    Article  CAS  PubMed  Google Scholar 

  22. McGrath MH (1990) Peptide growth factors and wound healing. Clin Plast Surg 17:421–432

    CAS  PubMed  Google Scholar 

  23. Steed D (1997) The role of growth factors in wound healing. Surg Clin N Am 77(3):575–586

    Article  CAS  PubMed  Google Scholar 

  24. Stadlemann W, Digenis A, Tobin G (1998) Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg 176(Suppl 2A):26S–38S

    Article  Google Scholar 

  25. Witte MB, Barbul A (1997) General principles of wound healing. Surg Clin N Am 77(3):509–528

    Article  CAS  PubMed  Google Scholar 

  26. Guo S, DiPietro LA (2010) Factors affecting wound healing: critical reviews in oral biology and medicine. J Dent Res 89(3):219–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Jonsson K, Jensen JA, Goodson WH 3rd, Scheuenstuhl H, West J, Hopf HW et al (1991) Tissue oxygenation, anemia and perfusion in relation to wound healing in surgical patients. Ann Surg 214(5):605–613

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Lavan FB, Hunt TK (1990) Oxygen and wound healing. Clin Plast Surg 17:463–472

    CAS  PubMed  Google Scholar 

  29. Wu L, Xia YP, Roth SI, Gruskin E, Mustoe TA (1999) Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: importance of oxygen and age. Am J Pathol 154(1):301–309

    Article  PubMed  PubMed Central  Google Scholar 

  30. Hunt TK, Hopf HW (1997) Wound healing and wound infection. What surgeons and anesthesiologists can do. Surg Clin N Am 77:587–606

    Article  CAS  PubMed  Google Scholar 

  31. Suh DY, Hunt TK (1998) Time line of wound healing. Clin Podiatr Med Surg 15:1–9

    CAS  PubMed  Google Scholar 

  32. Tandara AA, Mustoe TA (2004) Oxygen in wound healing— more than a nutrient. World J Surg 28:294–300

    Article  PubMed  Google Scholar 

  33. Bishop A (2008) Role of oxygen in wound healing. J Wound Care 17:399–402

    Article  CAS  PubMed  Google Scholar 

  34. Rodriguez PG, Felix FN, Woodley DT, Shim EK (2008) The role of oxygen in wound healing: a review of the literature. Dermatol Surg 34:1159–1169

    CAS  PubMed  Google Scholar 

  35. Grey JE, Harding KG, Enoch S (2006) Venous and arterial leg ulcers. BMJ 332(7537):347–350. doi:10.1136/bmj.332.7537.347

    Article  PubMed  PubMed Central  Google Scholar 

  36. Swift ME, Burns AL, Gray KL, DiPietro LA (2001) Age-related alterations in the inflammatory response to dermal injury. J Invest Dermatol 117:1027–1035

    Article  CAS  PubMed  Google Scholar 

  37. Minimas DA (2007) Ageing and its influence on wound healing. Wounds UK 3(1):42–50

    Google Scholar 

  38. Gilliver SC, Ashworth JJ, Ashcroft GS (2007) The hormonal regulation of cutaneous wound healing. Clin Dermatol 25:56–62

    Article  PubMed  Google Scholar 

  39. Godbout JP, Glaser R (2006) Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharmacol 1:421–427

    Article  PubMed  Google Scholar 

  40. Boyapati L, Wang HL (2007) The role of stress in periodontal disease and wound healing. Periodontology 2000(44):195–210

    Article  Google Scholar 

  41. Goodson WH, Hunt TK (1979) Wound healing and the diabetic patient. Surg Gynecol Obstet 149:600–608

    PubMed  Google Scholar 

  42. Kamal K, Powell RJ, Sumpio BE (1996) The pathobiology of diabetes mellitus: implications for surgeons. J Am Coll Surg 183:271–289

    CAS  PubMed  Google Scholar 

  43. Brownlee M, Cerami A, Vlassara H (1988) Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications. N Engl J Med 318:1315–1321

    Article  CAS  PubMed  Google Scholar 

  44. Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS et al (1994) Enhanced cellular oxidant stress by the interaction of advanced glycosylation end products with their receptors/binding proteins. J Biol Chem 269(13):9889–9897

    CAS  PubMed  Google Scholar 

  45. Kivirikko KI, Laitinen O, Aer J, Halme J (1967) Metabolism of collagen in experimental hyperthyroidism and hypothyroidism in the rat. Endocrinology 80:1051–1061

    Article  CAS  PubMed  Google Scholar 

  46. Coutinho W (1999) Latin America consensus on obesity. Arq Bras Endocrinol Metabol 43:21–67

    Google Scholar 

  47. Pitanguy I, De Amorim NFG, Radwanski HN (2000) Contour surgery in the patient with great weight loss. Aesthet Plast Surg 24(6):406–411

    Article  CAS  Google Scholar 

  48. Rosen JC, Orosan P, Reiter J (1995) Cognitive behavior therapy for negative body image in obese women. Behav Ther 26(1):25–42

    Article  Google Scholar 

  49. Postlethwait RW, Johnson WD (1972) Complications following surgery for duodenal ulcer in obese patients. Arch Surg 105(3):438–440

    Article  CAS  PubMed  Google Scholar 

  50. Printen KJ, Paulk SC, Mason EE (1975) Acute postoperative wound complications after gastric surgery for morbid obesity. Am Surg 41(8):483–485

    CAS  PubMed  Google Scholar 

  51. Matory WE, O’Sullivan J, Fudem G, Dunn R (1994) Abdominal surgery in patients with severe morbid obesity. Plast Reconstr Surg 94(7):976–987

    Article  PubMed  Google Scholar 

  52. Abdel-Moneim RI (1985) The hazards of surgery in the obese. Int Surg 70(2):101–103

    CAS  PubMed  Google Scholar 

  53. Carlson MA (1997) Acute wound failure. Surg Clin N Am 77(3):607–636

    Article  CAS  PubMed  Google Scholar 

  54. Yale CE (1989) Gastric surgery for morbid obesity. Complications and long-term weight control. Arch Surg 124(8):941–946

    Article  CAS  PubMed  Google Scholar 

  55. Thompson WR, Ameral JF, Caldwell MD (1983) Complications and weight loss in 150 consecutive gastric exclusion patients. Critical review. Am J Surg 146(5):602–612

    Article  CAS  PubMed  Google Scholar 

  56. Grazer FM, Goldwyn RM (1977) Abdominoplasty assessed by survey, with emphasis on complications. Plast Reconstr Surg 59(4):513–517

    Article  CAS  PubMed  Google Scholar 

  57. Franz MG, Steed DL, Robson MC (2007) Optimizing healing of the acute wound by minimizing complications. Curr Probl Surg 44:691–763

    Article  PubMed  Google Scholar 

  58. Wagner AE, Huck G, Stiehl DP, Jelkmann W, Hellwig-Burgel T (2008) Dexamethasone impairs hypoxia-inducible factor-1 function. Biochem Biophys Res Commun 372:336–340

    Article  CAS  PubMed  Google Scholar 

  59. Hofman D, Moore K, Cooper R, Eagle M, Cooper S (2007) Use of topical corticosteroids on chronic leg ulcers. J Wound Care 16:227–230

    Article  CAS  PubMed  Google Scholar 

  60. Su WH, Cheng MH, Lee WL, Tsou TS, Chang WH, Chen CS et al (2010) Nonsteroidal anti inflammatory drugs for wounds: pain relief or excessive scar formation? Mediat Inflamm. doi:10.1155/2010

    Google Scholar 

  61. Waldron DR, Zimmerman-Pope N (2003) Superficial skin wounds. In: Slatter DH (ed) Textbook of small animal surgery. Saunders, New York, pp 260–271

    Google Scholar 

  62. Choudhry MA, Chaudry IH (2006) Alcohol intoxication and post burn complications. Front Biosci 11:998–1005

    Article  CAS  PubMed  Google Scholar 

  63. Radek KA, Matthies AM, Burns AL, Heinrich SA, Kovacs EJ, Dipietro LA (2005) Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing. Am J Physiol Heart Circ Physiol 289:H1084–H1090

    Article  CAS  PubMed  Google Scholar 

  64. Radek KA, Kovacs EJ, DiPietro LA (2007) Matrix proteolytic activity during wound healing: modulation by acute ethanol exposure. Alcohol Clin Exp Res 31:1045–1052

    Article  CAS  PubMed  Google Scholar 

  65. Radek KA, Kovacs EJ, Gallo RL, DiPietro LA (2008) Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am J Physiol Heart Circ Physiol 295:H174–H184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Fitzgerald DJ, Radek KA, Chaar M, Faunce DE, DiPietro LA, Kovacs EJ (2007) Effects of acute ethanol exposure on the early inflammatory response after excisional injury. Alcohol Clin Exp Res 31:317–323

    Article  CAS  PubMed  Google Scholar 

  67. Chan LK, Withey S, Butler PE (2006) Smoking and wound healing problems in reduction mammaplasty: is the introduction of urine nicotine testing justified? Ann Plast Surg 56:111–115

    Article  CAS  PubMed  Google Scholar 

  68. Ahn C, Mulligan P, Salcido RS (2008) Smoking—the bane of wound healing: biomedical interventions and social influences. Adv Skin Wound Care 21:227–238

    Article  PubMed  Google Scholar 

  69. Levin L, Schwartz AD (2005) The effect of cigarette smoking on dental implants and related surgery. Implant Dent 14:357–361

    Article  PubMed  Google Scholar 

  70. Balaji SM (2008) Tobacco smoking and surgical healing of oral tissues: a review. Indian J Dent Res 19:344–348

    Article  CAS  PubMed  Google Scholar 

  71. Siana JE, Rex S, Gottrup F (1989) The effect of cigarette smoking on wound healing. Scand J Plast Reconstr Surg Hand Surg 23:207–209

    CAS  PubMed  Google Scholar 

  72. Goldminz D, Bennett RG (1991) Cigarette smoking and flap and full thickness graft necrosis. Arch Dermatol 127:1012–1015

    Article  CAS  PubMed  Google Scholar 

  73. Sorensen LT, Jorgensen S, Petersen LJ, Hemmingsen U, Bulow J, Loft S et al (2009) Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis. J Surg Res 152:224–230

    Article  CAS  PubMed  Google Scholar 

  74. Shepherd AA (2003) Nutrition for optimum wound healing. Nurs Stand 18:55–58

    PubMed  Google Scholar 

  75. Arnold M, Barbul A (2006) Nutrition and wound healing. Plast Reconstr Surg 117(7 Suppl):42S–58S

    Article  CAS  PubMed  Google Scholar 

  76. Gogia PP (1995) Physiology of wound healing. In: Gogia PP (ed) Clinical wound management. Thorofare, Slack, pp 8–12

    Google Scholar 

  77. Lanman TH, Ingalls TH (1937) Vitamin C deficiency and wound healing: an experimental and clinical study. Ann Surg 105(4):616–625

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. McDaniel JC, Belury M, Ahijevych K, Blakely W (2008) Omega-3 fatty acid’s effect on wound healing. Wound Repair Regen 16:337–345

    Article  PubMed  PubMed Central  Google Scholar 

  79. Shingel KI, Faure MP, Azoulay L, Roberge C, Deckelbaum RJ (2008) Solid emulsion gel as a vehicle for delivery of polyunsaturated fatty acids: implications for tissue repair, dermal angiogenesis and wound healing. J Tissue Eng Regen Med 2:383–393

    Article  CAS  PubMed  Google Scholar 

  80. Burgess C (2008) Topical vitamins. J Drugs Dermatol 7(7 Suppl):s2–s6

    PubMed  Google Scholar 

  81. Campos AC, Groth AK, Branco AB (2008) Assessment and nutritional aspects of wound healing. Curr Opin Clin Nutr Metab Care 11:281–288

    Article  PubMed  Google Scholar 

  82. Grey JE, Enoch S, Harding KG (2006) Wound assessment. BMJ 332(7536):285–288. doi:10.1136/bmj.332.7536.285

    Article  PubMed  PubMed Central  Google Scholar 

  83. Kumar KS, Reddy BE (2014) Wound image analysis classifier for efficient tracking of wound healing status. Signal Image Process Int J 5(2):15–27

    Article  Google Scholar 

  84. World Union of Wound Healing Societies (2007) Principles of best practice: wound exudate and the role of dressings. A consensus document. MEP Ltd, London

    Google Scholar 

  85. Robins (2003) Basic pathology, 7th edn. Elsevier, Amsterdam. ISBN: 818147-148-2

    Google Scholar 

  86. Krasner D (1995) Wound care. How to use red–yellow–black system. AJN 95(5):44–47

    CAS  PubMed  Google Scholar 

  87. Manakar NB, Nagdeve UT (2013) Comparison of different imaging techniques used for chronic wounds. IJRET 2(7):68–70

    Article  Google Scholar 

  88. Zhou AH (2012) A survey of optical imaging techniques for assessing wound healing. Int J Intell Control Syst 17(3):79–85

    Google Scholar 

  89. Falanga V (2000) Classifications for wound bed preparation and stimulation of chronic wounds. Wound Repair Regen 8:347–352

    Article  CAS  PubMed  Google Scholar 

  90. Schultz GS, Sibbald RG, Falanga V, Ayello EA, Dowsett C, Harding K, Romanelli M, Stacey MC, Teot L and Vanscheidt W (2003) Wound bed preparation : a systematic approach to wound management. Wound Repair Regen 11(2):S1–S27

    Article  PubMed  Google Scholar 

  91. Flanagan M (2013) Principles of wound management. In: Flanagan M (ed) Wound healing and skin integrity: principles and practice. Wiley-Blackwell, London, pp 66–83. ISBN: 978-0-470-65977-9

    Google Scholar 

  92. Wounds UK (2013) Effective debridement in a changing NHS: a UK consensus. Wounds UK, London. www.wounds-uk.com

  93. Strohal R, Dissemond J, O’Brien J, Piaggesi A, Rimdeika R, Young T et al (2013) An updated overview and clarification of the principle role of debridement. EWMA document: debridement. J Wound Care 22:S1–S52

    PubMed  Google Scholar 

  94. Dodds S, Haynes S (2004) The wound edge, epithelialization and monitoring wound healing. A journey through TIME. Wound bed preparation in practice. Br J Nurs Supplement 13(18):23–26

    Google Scholar 

  95. Borle RM (2014) Textbook of oral and maxillofacial surgery. Chapter 2: Sutures, 1st edn. Jaypee Brothers, New Delhi. ISBN: 978-93-5152-009-2

    Book  Google Scholar 

  96. Turner TD (2001) Development of wound management products in chronic wound care. In: Krasner D, Rodeheaver G, Sibbald RG, (eds) Chronic wound care: a clinical source book for healthcare professionals, 3rd edn. HMP Communications, Wayne, PA

    Google Scholar 

  97. https://nstupharma.files.wordpress.com/2012/11/maimum-surgical-dressing1.pdf

  98. Hyslop PA, Hinshaw DE, Scraufsratter IU (1995) Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radic Biol Med 19(11):31–37

    Article  CAS  PubMed  Google Scholar 

  99. Shenoy VP, Balla M, Shivananda PG, Bairy I (2012) Honey as an antimicrobial agent against Pseudomonas aeruginosa isolated from infected wounds. J Glob Infect Dis 4(2):102–105. doi:10.4103/0974-777X.96770

    Article  PubMed  PubMed Central  Google Scholar 

  100. Bergman A, Yanai J, Weiss J, Bell D, David MP (1983) Acceleration of wound healing by topical application of honey: an animal model. Am J Surg 145(3):374–376

    Article  CAS  PubMed  Google Scholar 

  101. Atherton P (1998) Aloe vera: magic or medicine? Nurs Stand 12(49):52–54

    Google Scholar 

  102. Davis RH, Didonato JJ, Hartman GM, Haas RC (1994) Anti-inflammatory and wound healing activity of a growth substance in aloe vera. J Am Podiatr Med Assoc 84(2):77–81

    Article  CAS  PubMed  Google Scholar 

  103. Yadav KC, Kumar RJ, Basha S, Deshmukh GR, Gujjula R, Santhamma B (2012) Wound healing activity of topical application of aloe vera gel in experimental animal models. Int J Pharm Bio Sci 3(2):63–72

    Google Scholar 

  104. Higley HR, Ksander GA, Gerhardt CO, Falanga V (1995) Extravasation of macromolecules and possible trapping of transforming growth factors-beta in venous ulcerations. Br J Dermatol 132:79–85

    Article  CAS  PubMed  Google Scholar 

  105. Trengone NJ, Stacey MC, MacAuley S (1999) Analysis of acute and chronic wound environment: the role of proteases and their inhibitors. Wound Repair Regen 7:442–452

    Article  Google Scholar 

  106. Trengone NJ, Ohmann HB, Stacey MC (2000) Miogenic activity and cytokine levels in nonhealing and healing chronic leg ulcers. Wound Repair Regen 8:13–25

    Article  Google Scholar 

  107. Robson MC, Smith PD (2001) Topical use of growth factors to enhance healing. In: Falanga V (ed) Cutaneous wound healing. Martin Dunitz, London, pp 379–398

    Google Scholar 

  108. Margolis DJ, Bartus C, Hoffstad O, Malay S, Berlin JA (2005) Effectiveness of recombinant human PDGF for treatment of diabetic neuropathic foot ulcers. Wound Repair Regen 13:531–536

    Article  PubMed  Google Scholar 

  109. Hess CT (2005) Wound care, 5th edn. Lippincott Williams and Wilkins, Baltimore

    Google Scholar 

  110. Zhang X, Wu X, Wolf SE, Hawkins HK, Chinkes DL, Wolfe RR et al (2007) Local insulin zinc injection accelerated skin closure donor site wound healing. J Surg Res 142:90–96

    Article  CAS  PubMed  Google Scholar 

  111. Greenway SE, Filler LE, Greenway FL (1999) Topical insulin in wound healing: a randomized double blind, placebo controlled trial. J Wound Care 8:526–528

    Article  CAS  PubMed  Google Scholar 

  112. Rezvani O, Shabbak E, Aslam A, Bidar R, Jafari M, Safanezhad S (2009) A randomized double blind placebo controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Manag 55:22–28

    Google Scholar 

  113. Chen X, Liu Y, Zhang X (2010) Topical insulin application improves healing by regulating the wound inflammatory response. Wound Repair Regen 20:425–434

    Article  Google Scholar 

  114. Baumann LS, Spencer J (1999) The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 25:311–315

    Article  CAS  PubMed  Google Scholar 

  115. Pinnel SR (1999) Regarding d-alpha tocopherol. Dermatol Surg 25:827

    Article  Google Scholar 

  116. Mackay D, Miller AL (2003) Nutritional support for wound healing. Altern Med Rev 8:359–377

    PubMed  Google Scholar 

  117. Hopkins JT, McLoda TA, Seegmiller JG, David Baxter G (2004) Low-level laser therapy facilitates superficial wound healing in humans: a triple-blind, sham-controlled study. J Athl Train 39(3):223–229

    PubMed  PubMed Central  Google Scholar 

  118. Silva EC, Filho AH, Musskopf DE (1998) Radiação laser. In: Rodrigues EM (ed) Manual de recursos terapêuticos. Revinter, Rio de Janeiro, pp 17–35

    Google Scholar 

  119. Karu T, Pyatibrat L, Kalendo G (1995) Irradiation with He–Ne laser increases ATP level in cells cultivated in vitro. J Photochem Photobiol, B 27:219–223

    Article  CAS  Google Scholar 

  120. Bibikova A, Belkin V, Oron U (1994) Enhancement of angiogenesis in regenerating gastrocnemius muscle of the toad (Bufo viridis) by low-energy laser irradiation. Anat Embryol (Berl) 190:597–602

    Article  CAS  Google Scholar 

  121. Kloth LC, Mc Culloch MJ (1996) Promotion of wound healing with electrical stimulation. Adv Wound Care 9(5):42–45

    CAS  PubMed  Google Scholar 

  122. Weller C, Sussman G (2006) Wound dressings update. J Pharm Pract Res 36(4):318–324

    Article  Google Scholar 

  123. Tocco I, Zavan B, Bassetto F, Vindigni V (2012) Nanotechnology-based therapies for skin wound regeneration. J Nanomater. doi:10.1155/2012/714134

    Google Scholar 

  124. Whitehead W (1891) A hundred cases of entire excision of the tongue. Br Med J 1(1583):961

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  125. Davies H, Carr R (1990) Osteomyelitis of the mandible: a complication of routine dental extractions in alcoholics. Br J Oral Maxillofac Surg 28(3):185–188

    Article  CAS  PubMed  Google Scholar 

  126. Stanley D, Emerson D, Daley J (1988) Whitehead’s varnish and Jelonet—a better dressing for skin graft donor sites than Jelonet alone. Ann R Coll Surg Engl 70(6):369

    CAS  PubMed  PubMed Central  Google Scholar 

  127. Stoelinga P, Bronkhorst F (1988) The incidence, multiple presentation and recurrence of aggressive cysts of the jaws. J Cranio-Maxillofac Surg 16:184–195

    Article  CAS  Google Scholar 

  128. Eyre J, Zakrzewska J (1985) The conservative management of large odontogenic keratocysts. Br J Oral Maxillofac Surg 23(3):195–203

    Article  CAS  PubMed  Google Scholar 

  129. Hellem S, Nordenram A (1973) Prevention of postoperative symptoms by general antibiotic treatment and local bandage in removal of mandibular third molars. Int J Oral Surg 2(6):273–278

    Article  CAS  PubMed  Google Scholar 

  130. Rowe-Jones J, Adam E, Moore-Gillon V (1993) Subtle diagnostic markers of orbital floor blow-out fracture on coronal CT scan. J Laryngol Otol 107(02):161–162

    Article  CAS  PubMed  Google Scholar 

  131. Braithwaite F, Maurice D (1968) The importance of the levator palati muscle in cleft palate closure. Br J Plast Surg 21(1):60–62

    Article  CAS  PubMed  Google Scholar 

  132. Morison R (1917) Remarks on the treatment of infected, especially war wounds. Br Med J 2(2964):503–506

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  133. Nakhla V, Takwoingi YM, Sinha A (2007) Myringoplasty: a comparison of bismuth iodoform paraffin paste gauze pack and tri-adcortyl ointment ear dressing. J Laryngol Otol 121(4):329–332

    Article  CAS  PubMed  Google Scholar 

  134. Kotecha B, Fowler S, Harkness P, Walmsley J, Brown P, Topham J (1996) Management of epistaxis: a national survey. Ann R Coll Surg Engl 78(5):444–446

    CAS  PubMed  PubMed Central  Google Scholar 

  135. Corbridge RJ, Djazaeri B, Hellier WP, Hadley J (1995) A prospective randomised controlled trial comparing the use of merocel nasal tampons and BIPP in the control of acute epistaxis. Clin Otolaryngol Allied Sci 20(4):305–307

    Article  CAS  PubMed  Google Scholar 

  136. Flook EP, Uddin FJ, Johnston MN (2006) The need to include BIPP reactions in routine consent. Clin Otolaryngol 31(2):165–166

    Article  CAS  PubMed  Google Scholar 

  137. Youngman L, Harris S (2004) BIPP madness: an iatrogenic cause of acute confusion. Age Ageing 33(4):406–407

    Article  PubMed  Google Scholar 

  138. Elvis AM, Ekta JS (2011) Ozone therapy; a clinical review. J Nat Sci Biol Med 2(1):66–70. doi:10.4103/0976-9668.82319

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  139. O’Neil T (1975) Antibacterial properties of periodontal dressings. J Periodontol 46(8):469

    Article  PubMed  Google Scholar 

  140. Singh V, Das S, Sharma NK (2012) Iodoform—a boon in disguise. Open Journal of Stomatology. doi:10.4236/ojst.2012.24055

    Google Scholar 

  141. Hahler B (2006) Surgical wound dehiscence. Medsurg Nurs 15:296–300

    PubMed  Google Scholar 

  142. Amini AQ, Khan NA, Ahmed J, Memon AS (2013) Management of abdominal wound dehiscence: still a challenge. Pak J Surg 29(2):84–87

    Google Scholar 

  143. Russell SB, Trupin JS, Kennedy RZ, Russel JD, Davidson JM (1995) Glucocorticoid regulation of elastin synthesis in human fibroblasts: down regulation in fibroblasts from normal dermis but not from keloids. J Invest Dermatol 105:241–245

    Article  Google Scholar 

  144. Babu M, Diegelmann R, Oliver N (1989) Fibronectin is overproduced by keloid fibroblasts during abnormal wound healing. Mol Cell Biol 9:1642–1650

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  145. Brissett AE, Sherris DA (2001) Scar contractures, hypertrophic scars, and keloids. Facial Plast Surg 17:263–272

    Article  CAS  PubMed  Google Scholar 

  146. Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschkw MG (2011) Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med 17(1–2):113–125. doi:10.2119/molmed.2009.00153

    CAS  PubMed  Google Scholar 

  147. Mutalik S (2005) Treatment of keloids and hypertrophic scars. Indian J Dermatol Venereol Leprol 71(1):3–8

    Article  PubMed  Google Scholar 

  148. Naeini FF, Najafian J, Ahmadpour K (2006) Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars. Dermatol Surg 32:1023–1029 (discussion 1029-1030)

    CAS  PubMed  Google Scholar 

  149. Segev F, Jaeger-Roshu S, Gefen-Carmi N, Assia EI (2003) Combined mitomycin C application and free flap conjunctival autograft in pterygium surgery. Cornea 22:598–603

    Article  PubMed  Google Scholar 

  150. Wolfram D, Tzankov A, Pulzi P, Katzer HP (2009) Hypertrophic scars and keloids. A review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg 35:171–181. doi:10.1111/j.1524-4725.2008.34406.x

    Article  CAS  PubMed  Google Scholar 

  151. Healy B, Freedman A (2006) Infections. BMJ 332(7545):838–841

    Article  PubMed  PubMed Central  Google Scholar 

  152. Tregdet EE, Nedelec B, Scott PG, Ghahary A (1997) Hypertrophic scars and contractures: the cellular and molecular basis for therapy. Surg Clin N Am 77(3):701–730

    Article  Google Scholar 

  153. Moioli EK, Bakus AD, Yaghmai D, Hernandez C (2011) Treatment strategies for pigmentation disorders in skin of color. Cosmet Dermatol 24(11):524–531

    Google Scholar 

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Correspondence to Avneet Kaur.

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Shruti Chhabra, Naveen Chhabra, Avneet Kaur and Niti Gupta declare that they have no conflict of interest.

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Chhabra, S., Chhabra, N., Kaur, A. et al. Wound Healing Concepts in Clinical Practice of OMFS. J. Maxillofac. Oral Surg. 16, 403–423 (2017). https://doi.org/10.1007/s12663-016-0880-z

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  • DOI: https://doi.org/10.1007/s12663-016-0880-z

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