Abstract
Aims
To evaluate the efficacy of autologous platelet rich plasma (PRP) in regeneration of bone and to assess clinical compatibility of the material in mandibular third molar extraction socket.
Objective of the Study
To compare the healing of mandibular third molar extraction wounds with and without PRP.
Materials and Methods
Group A consists of the 30 patients where PRP will be placed in the extraction socket before closure of the socket. Group B consists of 30 patients who will be the control group where the extraction sockets will be closed without any intra socket medicaments. The patients would be allocated to the groups randomly.
Results
Soft tissue healing was better in study site compared to control site. The result of the study shows rapid bone regeneration in the extraction socket treated with PRP when compared with the socket without PRP. Evaluation for bone blending and trabecular bone formation started earlier in PRP site compared to control, non PRP site. Also there was less postoperative discomfort on the PRP treated side.
Conclusion
Autologous PRP is biocompatible and has significant improved soft tissue healing, bone regeneration and increase in bone density in extraction sockets.
Similar content being viewed by others
References
Aghaloo TL, Moy PK, Freymiller EG (2002) Investigation of platelet rich plasma in rabbit cranial defects: a pilot study. J Oral Maxillofac Surg 60:1176–1181
Freymiller EG, Aghaloo TL (2004) Platelet rich plasma: ready or not? J Oral Maxillofac Surg 62:484–488
Marx RE (2004) Platelet rich plasma: evidence to support its use. J Oral Maxillofac Surg 62:489–496
Landry RG, Turnbull RS, Howley T (1988) Effectiveness of benzydamyne HCl in the treatment of periodontal post surgical patients. Res Clin Forums 10:105–118
Blum IR (2002) Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. Int J Oral Maxillofac Surg 31:309–317
Ogundipe OK, Ugboko VI (2011) Can autologous platelet rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg 69:2305–2310
Gonshor A (2002) Technique for producing platelet rich plasma and platelet concentrate: background and process. Int J Periodontics Restor Dent 22:547–557
Robiony M, Polini F, Politi M (2002) Osteogenesis distraction and platelet rich plasma for bone reconstruction of the severely atrophic mandible: preliminary results. J Oral Maxillofac Surg 60:630–635
Shanaman R, Filstein MR, Danesh-Meyer MJ (2001) Localized ridge augmentation using GBR and platelet rich plasma: three case reports. Int J Periodontics Restor Dent 21:343
Powell DM, Chang E, Farrior EH (2001) Recovery from deep plane rhytidectomy following unilateral wound treatment with autologous platelet gel: a pilot study. Arch Facial Plast Surg 3(4):245–250
Pradel W, Eckelt U, Lauer G (2006) Radiographic assessment of impacted mandibular third molar socket filled with composite xenogenic bone graft. Dentomaxillofacial Radiol 35:371–375
Smet ED, Jacobs R, Gijbels F, Naert I (2002) The accuracy and reliability of radiographic methods for the assessment of marginal bone level around oral implants. Dentomaxillofacial Radiol 31:176–181
Simon D (2004) Potential for osseous regeneration of platelet rich plasma—a comparative study in mandibular third molar sockets. Ind J Dent Res 15(4):133–136
Kim SG, Kim WK, Park JC, Kim HJ (2002) A comparative study of osseointegration of avana implants in a demineralized freeze dried bone alone or with platelet rich plasma. J Oral Maxillofac Surg 60:1018–1025
Wang HL, Avila G (2007) Platelet rich plasma: myth or reality? Eur J Dent 1(4):192–194
Tsay RC, Jennifer VO, Burke A, Eisig S, Landesberg R (2005) Differential growth factor retention by platelet rich plasma composites. J Oral Maxillofac Surg 63:521–528
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dutta, S.R., Singh, P., Passi, D. et al. Mandibular Third Molar Extraction Wound Healing With and Without Platelet Rich Plasma: A Comparative Prospective Study. J. Maxillofac. Oral Surg. 14, 808–815 (2015). https://doi.org/10.1007/s12663-014-0738-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12663-014-0738-1