Abstract
Introduction
Simvastatin, a common cholesterol-lowering drug that inhibits hepatic hydroxymethylglutaryl coenzyme A reductase, the rate-limiting enzyme in the mevalonate pathway, increases expression of the BMP-2 gene and thus promotes bone regeneration.
Materials and methods
A study was conducted in mandibular third molar sockets to study the efficacy of the drug by implanting it into sockets (experimental group) and observations were made over 3 months to compare the healing with the (control group).
Conclusion
The results showed faster regeneration of the bone in the simvastatin site using the gray level histogram values.
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Chauhan, A.S., Maria, A. & Managutti, A. Efficacy of Simvastatin in Bone Regeneration After Surgical Removal of Mandibular Third Molars: A Clinical Pilot Study. J. Maxillofac. Oral Surg. 14, 578–585 (2015). https://doi.org/10.1007/s12663-014-0697-6
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DOI: https://doi.org/10.1007/s12663-014-0697-6