Journal of Maxillofacial and Oral Surgery

, Volume 13, Issue 3, pp 281–285

Matrix Metalloproteinase-9 (MMP-9) Expression in Different Subtypes of Ameloblastoma

  • Rachmitha Anne
  • Ening Krisnuhoni
  • Chusnul Chotimah
  • Benny Sjarief Latief
Research Paper

DOI: 10.1007/s12663-013-0538-z

Cite this article as:
Anne, R., Krisnuhoni, E., Chotimah, C. et al. J. Maxillofac. Oral Surg. (2014) 13: 281. doi:10.1007/s12663-013-0538-z



Ameloblastoma is a common benign odontogenic tumor of the jaw with a local invasive and highly destructive behavior and can develop in any age, with peak prevalence in 3rd–4th decade. Ameloblastoma can be divided into six histological types: follicular, plexiform, acanthomatous, desmoplastic, granular, and basal cell. Matrix metalloproteinase-9 (MMP-9) (92-kD gelatinase/type IV collagenases = gelatinase B) is involved in bone resorption by degradation of extracellular matrix and osteoclasts recruitment. Recent studies have found that MMP-9 is expressed by ameloblastoma and has a role in ameloblastoma local invasiveness.


To analyze MMP-9 expression between different histological types of ameloblastoma.

Material and Method

Forty samples of ameloblastoma were collected through consecutive sampling and the MMP-9 expression was detected using immunohistochemistry.


All samples showed positive MMP-9 expression with moderate to strong intensity. 82.4 % plexiform type and 83.3 % mixed type have strong immunoexpression, significantly different with follicular type with only 36.4 % (P < 0.05).


Ameloblastoma plexiform and mixed type have higher MMP-9 expression than ameloblastoma follicular type. Different MMP-9 expression may contribute in different ameloblastoma biological behavior.


Ameloblastoma Histological subtypes MMP-9 Local invasion 

Copyright information

© Association of Oral and Maxillofacial Surgeons of India 2013

Authors and Affiliations

  • Rachmitha Anne
    • 1
  • Ening Krisnuhoni
    • 2
  • Chusnul Chotimah
    • 1
  • Benny Sjarief Latief
    • 1
  1. 1.Department of Oral and Maxillofacial Surgery, Faculty of DentistryUniversity of IndonesiaJakarta PusatIndonesia
  2. 2.Department of Pathological Anatomy, Faculty of MedicineUniversity of Indonesia Jakarta PusatIndonesia

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