Journal of Maxillofacial and Oral Surgery

, Volume 12, Issue 3, pp 243–247 | Cite as

Cyanoacrylate: A Handy Tissue Glue in Maxillofacial Surgery: Our Experience in Alexandria, Egypt

Research Paper


Cyanoacrylate tissue glue has been widely used in different surgical applications. It is easy to apply and can save considerable time and effort. Reports including series of oral and maxillofacial cases are yet to be well documented. We report our experience using cyanoacrylate tissue glue in the head and neck region in 165 patients. We have used it for indications including orbital floor graft fixation, cleft lip and palate repair, oral dressing, skin graft fixation, nasal splinting, immobilisation of traumatised teeth, management of chyle leak during neck dissection and wound closure. We have not had any complications from using cyanoacrylate. It is found to be safe and effective in different indications it is used for without undue hazards. The role of cyanoacrylate in oral and maxillofacial surgery needs further research.


Cyanoacrylate Maxillofacial Glue Applications 


  1. 1.
    Carton CA, Kessler LA, Seidenberg B et al (1960) A plastic adhesive method of small blood vessel surgery. World Neurol 1:356–362PubMedGoogle Scholar
  2. 2.
    Watson DR, Maguda TA (1965) An experimental study of closure of tympanic perforations with fascia and an adhesive. South Med J 58:844–847CrossRefGoogle Scholar
  3. 3.
    Lehman RA, Hayes GJ, Martins AN (1967) The use of adhesive and lyophilized dura in the treatment of cerebrospinal rhinorrhea. J Neurosurg 26:92–95PubMedCrossRefGoogle Scholar
  4. 4.
    Penoff J (1999) Skin closures using cyanoacrylate tissue adhesives. Plastic surgery Educational foundation DATA committee. device and technique assessment. Plast Reconstr Surg 103:730–731PubMedCrossRefGoogle Scholar
  5. 5.
    Chang CJ, Hou MC, Lin HC, Lee HS, Liao WC, Su CW et al (2010) The safety and probable therapeutic effect of routine use of antibiotics and simultaneously treating bleeding gastric varices by using endoscopic cyanoacrylate injection and concomitant esophageal varices with banding ligation: a pilot study. Gastrointest Endosc 71:1141–1149PubMedCrossRefGoogle Scholar
  6. 6.
    Tzifa KT, Maxwell EL, Chait P, James AL, Forte V, Ein SH, Friedburg J (2006) Endoscopic treatment of congenital H-type and recurrent tracheoesophageal fistula with electrocautery and Histoacryl glue. Int J Pediatr Otorhinolaryngol 70:925–930PubMedCrossRefGoogle Scholar
  7. 7.
    Goldman SY, Greben CR, Setton A, McKinley MJ, Axelrod DJ, Charles HW, Gandras EJ (2007) Bronchobiliary fistula successfully treated with n-butyl cyanoacrylate via a bronchial approach. J Vasc Interv Radiol 18:151–155PubMedCrossRefGoogle Scholar
  8. 8.
    Hida K, Yamaguchi S, Seki T, Yano S, Akino M, Terasaka S, Uchida T, Iwasaki Y (2006) Nonsuture dural repair using polyglycolic acid mesh and fibrin glue: clinical application to spinal surgery. Surg Neurol 65:136–142PubMedCrossRefGoogle Scholar
  9. 9.
    Adler N, Nachumovsky S, Meshulam-Derazon S, Ad-El D (2007) Skin graft fixation with cyanoacrylate tissue adhesive in burn patients. Burns 33:803PubMedCrossRefGoogle Scholar
  10. 10.
    Hallock GG (2001) Expanded applications for octyl-2-cyanoacrylate as a tissue adhesive. Ann Plast Surg 46:185–189PubMedCrossRefGoogle Scholar
  11. 11.
    Buckley MJ, Beckman EJ (2010) Adhesive use in oral and maxillofacial surgery. Oral Maxillofac Surg Clin North Am 22:195–199PubMedCrossRefGoogle Scholar
  12. 12.
    Kaneko R, Tohnai I, Ueda M, Negoro M, Yoshida J, Yamada Y (2001) Curative treatment of central hemangioma in the mandible by direct puncture and embolisation with n-butylcyanoacrylate (NBCA). Oral Oncol 37:605–608PubMedCrossRefGoogle Scholar
  13. 13.
    Loureiro CC, Falchet PC, Gavranich J Jr, Lobo Leandro LF (2010) Embolization as the treatment for a life-threatening mandibular arteriovenous malformation. J Craniofac Surg 21:380–382PubMedCrossRefGoogle Scholar
  14. 14.
    Carneiro SC, Batista LL, Vasconcelos BC, Maranhão CA, Panazzolo G, Queiroz IV, Medeiros JR (2009) Massive oral hemorrhage due to mandibular arteriovenous malformation treated with percutaneous approach–a case report. J Oral Maxillofac Surg 67:25–28Google Scholar
  15. 15.
    Blythe JN, Habib A, Gulati A, Brennan PA (2011) Use of N-butyl-2-cyanoacrylate tissue glue in thoracic duct injury during neck dissection surgery. Br J Oral Maxillofac Surg 49:486–487PubMedCrossRefGoogle Scholar
  16. 16.
    Coover PC, Shearer NHJ (1957) Eastman Kodak Co. U.S. patent no. 2,794,788Google Scholar
  17. 17.
    Cavanaugh TB, Gottsch DJ (1991) Infectious keratitis and cyanoacrylate adhesive. Am J Ophthalmol 111:466–472PubMedGoogle Scholar
  18. 18.
    Hirst LW, Smiddy WE, Stark WJ (1982) Corneal perforations. Changing methods of treatment, 1960–1980. Ophthalmology 89:630–635PubMedGoogle Scholar
  19. 19.
    Leahey AB, Gottsch JD, Stark WJ (1993) Clinical experience with N-butyl cyanoacrylate (Nexactyl) tissue adhesive. Ophthalmology I00:173–180Google Scholar
  20. 20.
    Wilkinson TS, Rybka FJ (1971) Experimental study of prevention of tip necrosis in ischemic Z plasties. Plast Reconstr Surg 47:37–38PubMedCrossRefGoogle Scholar
  21. 21.
    Vishwanathan H, Hamilton DW, Ibrahim E, Youssef H, Pahor AL (2007) Superglue in otology. Surgeon 5:10–12PubMedCrossRefGoogle Scholar
  22. 22.
    Setlik DE, Seldomridge DL, Adelman RA, Semchyshyn TM, Afshari NA (2005) The effectiveness of isobutyl cyanoacrylate tissue adhesive for the treatment of corneal perforations. Am J Ophthalmol 140:920–921PubMedCrossRefGoogle Scholar
  23. 23.
    Tse DT (1986) Cyanoacrylate tissue adhesive in securing orbital implants. Ophthalmic Surg 17:577–580PubMedGoogle Scholar
  24. 24.
    Shepler TR, Seiff SR (2001) Use of isobutyl cyanoacrylate tissue adhesive to stabilize external eyelid weights in temporary treatment of facial palsies. Ophthal Plast Reconstr Surg 17:169–173PubMedCrossRefGoogle Scholar
  25. 25.
    Wilson AD, Mercer N (2010) Use of Dermabond in cleft lip repair. J Plast Reconstr Aesthet Surg 63:1064–1065PubMedCrossRefGoogle Scholar
  26. 26.
    Choi BH, Kim BY, Huh JY, Lee SH, Zhu SJ, Jung JH, Li J (2006) Cyanoacrylate adhesive for closing sinus membrane perforations during sinus lifts. J Craniomaxillofac Surg 34:505–509PubMedCrossRefGoogle Scholar
  27. 27.
    Kondoh S, Matsuo K, Yuzuriha S, Kikuchi N, Ban R (2003) Dressing for alveolopalatal wounds after alveolar bone grafting. Ann Plast Surg 51:290–293PubMedCrossRefGoogle Scholar
  28. 28.
    Cobb AR, Ahmad S, Kumar M (2011) Use of n-butyl 2-cyanoacrylate tissue adhesive to splint traumatised teeth in the emergency department. Br J Oral Maxillofac Surg 49:483–485PubMedCrossRefGoogle Scholar

Copyright information

© Association of Oral and Maxillofacial Surgeons of India 2012

Authors and Affiliations

  1. 1.Department of Maxillofacial and Plastic Surgery, Faculty of DentistryAlexandria UniversityAlexandriaEgypt
  2. 2.Department of Otolaryngology, Faculty of MedicineAlexandria UniversityAlexandriaEgypt

Personalised recommendations