Abstract
The lingering numbness that can last anywhere from 3 to 5 h after a routine dental procedure is often an unnecessary, inconvenient hassle. Patients may find that their ability to speak, smile, eat and drink is impaired, and may even have uncontrollable drooling. The effects of local dental anesthetics can now be reversed. That’s because OraVerse, an anesthetic reversal agent, can return the patient to normal sensation and function in about half the time. OraVerse which is U.S. Food and Drug Administration approved is a safe and effective form of phentolamine mesylate, a vasodilator that has been used in several other medical applications since 1952. OraVerse injection – the first and only proven safe and effective product of its kind can quickly reverse the effects of local dental anesthetics, so patient can carry on without impairment of talk, smile and drink after dental procedures. Studies also have shown that there are no known drug interactions and no evident toxicity or contraindications for using OraVerse.
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References
Wynn RL (2009) Phentolamine mesylate-An old medical drug becomes a new dental drug. Gen Dent 57(3):200–202
Morrow T (2008) OraVerse helps you lose that numbing feeling. Manag Care 17(90):50–51
Drugs.com [Internet]. Drug information on line; C 2000-10 Micromedex™ [Updated 2 July 2010], Cerner Multum™ [Updated 24 August 2010], Wolters Kluwer™ [Updated 2 September 2010; Cited 2010 Sept 6]. Available from http://www.drugs.com/pro/oraverse.html
Myklejord DJ (2004) Undiagnosed pheochromocytoma: the anesthesiologist nightmare. Clin Med Res 2(1):59–62
Ceatus Media Group LLC [Internet]. Consumer Guide to Dentistry; C 2006-10 [Up dated 2010 May13; Cited 2010 Sep 6]. Available from http://www.yourdentistryguide.com/oraverse/
Hersh EV, Moore PA, Papas AS, Goodson JM, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults. J Am Dent Assoc 139(8):1080–1093
Weaver JM (2008) New drugs on the horizon may improve the quality and safety of anesthesia. Anesth Prog 55(2):27–28
Malamed S (2009) What’s new in local anesthesia? SAAD Dig 25:4–14
Gould L, Reddy CV, Chua W (1977) Electrophysiological Properties of Phentolamine in Man. Br Heart J 39(9):939–944
Roberts JR, Krisanda TJ (1989) Accidental Intra-Arterial Injection of Epinephrine Treated With Phentolamine. Ann Emerg Med 18(4):424–425
Rutherford B, Zeller JR, Thake D (2009) Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse). Anesth Prog 56(4):123–127
Laviola M, McGavin SK, Freer GA, Plancich G, Woodbury SC, Marinkovich S et al (2008) Randomized study of phentolamine mesylate for reversal of local anesthesia. J Dent Res 87(7):635–639
Tavares M, Goodson JM, Studen-Pavlovich D, Yagiela JA, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. J Am Dent Assoc 139(8):1095–1104
Malamed SF (2010) Local anesthesia reversal. Dent Today 29(3):65–66
Hill JM (1991) Phentolamine mesylate: the antidote for vasopressor extravasation. Crit Care Nurse 11(10):58–61
Moore PA, Hersh EV, Papas AS, Goodson JM, Yagiela JA, Rutherford B et al (2008) Pharmaco kinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate. Anesth Prog 55(2):40–48
Poulet FM, Berardi MR, Halliwell W, Hartman B, Auletta C, Bolte H (2004) Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol 32(5):558–566
Hersh EV, Hermann DG, Lamp CJ, Johnson PD, Mac A, fee KA (1995) Assessing the duration of mandibular soft tissue anesthesia. J Am Dent Assoc 126(11):1531–1536
Cooper BE (1989) High-dose phentolamine for extravasation of pressors. Clin Pharm 8(10):689
Mc Cleane GJ (1996) Oral phentolamine mesylate in the treatment of complex regional pain Syndrome. Ulst Med J 65(1):87–88
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Prasanna, J.S. OraVerse: Reverses Numbness After Dental Procedures. J. Maxillofac. Oral Surg. 11, 212–219 (2012). https://doi.org/10.1007/s12663-011-0318-6
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DOI: https://doi.org/10.1007/s12663-011-0318-6