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OraVerse: Reverses Numbness After Dental Procedures

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Abstract

The lingering numbness that can last anywhere from 3 to 5 h after a routine dental procedure is often an unnecessary, inconvenient hassle. Patients may find that their ability to speak, smile, eat and drink is impaired, and may even have uncontrollable drooling. The effects of local dental anesthetics can now be reversed. That’s because OraVerse, an anesthetic reversal agent, can return the patient to normal sensation and function in about half the time. OraVerse which is U.S. Food and Drug Administration approved is a safe and effective form of phentolamine mesylate, a vasodilator that has been used in several other medical applications since 1952. OraVerse injection – the first and only proven safe and effective product of its kind can quickly reverse the effects of local dental anesthetics, so patient can carry on without impairment of talk, smile and drink after dental procedures. Studies also have shown that there are no known drug interactions and no evident toxicity or contraindications for using OraVerse.

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References

  1. Wynn RL (2009) Phentolamine mesylate-An old medical drug becomes a new dental drug. Gen Dent 57(3):200–202

    PubMed  Google Scholar 

  2. Morrow T (2008) OraVerse helps you lose that numbing feeling. Manag Care 17(90):50–51

    PubMed  Google Scholar 

  3. Drugs.com [Internet]. Drug information on line; C 2000-10 Micromedex [Updated 2 July 2010], Cerner Multum [Updated 24 August 2010], Wolters Kluwer [Updated 2 September 2010; Cited 2010 Sept 6]. Available from http://www.drugs.com/pro/oraverse.html

  4. Myklejord DJ (2004) Undiagnosed pheochromocytoma: the anesthesiologist nightmare. Clin Med Res 2(1):59–62

    Article  PubMed  Google Scholar 

  5. Ceatus Media Group LLC [Internet]. Consumer Guide to Dentistry; C 2006-10 [Up dated 2010 May13; Cited 2010 Sep 6]. Available from http://www.yourdentistryguide.com/oraverse/

  6. Hersh EV, Moore PA, Papas AS, Goodson JM, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults. J Am Dent Assoc 139(8):1080–1093

    PubMed  Google Scholar 

  7. Weaver JM (2008) New drugs on the horizon may improve the quality and safety of anesthesia. Anesth Prog 55(2):27–28

    Article  PubMed  Google Scholar 

  8. Malamed S (2009) What’s new in local anesthesia? SAAD Dig 25:4–14

    PubMed  Google Scholar 

  9. Gould L, Reddy CV, Chua W (1977) Electrophysiological Properties of Phentolamine in Man. Br Heart J 39(9):939–944

    Article  PubMed  CAS  Google Scholar 

  10. Roberts JR, Krisanda TJ (1989) Accidental Intra-Arterial Injection of Epinephrine Treated With Phentolamine. Ann Emerg Med 18(4):424–425

    Article  PubMed  CAS  Google Scholar 

  11. Rutherford B, Zeller JR, Thake D (2009) Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse). Anesth Prog 56(4):123–127

    Article  PubMed  Google Scholar 

  12. Laviola M, McGavin SK, Freer GA, Plancich G, Woodbury SC, Marinkovich S et al (2008) Randomized study of phentolamine mesylate for reversal of local anesthesia. J Dent Res 87(7):635–639

    Article  PubMed  CAS  Google Scholar 

  13. Tavares M, Goodson JM, Studen-Pavlovich D, Yagiela JA, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. J Am Dent Assoc 139(8):1095–1104

    PubMed  Google Scholar 

  14. Malamed SF (2010) Local anesthesia reversal. Dent Today 29(3):65–66

    PubMed  Google Scholar 

  15. Hill JM (1991) Phentolamine mesylate: the antidote for vasopressor extravasation. Crit Care Nurse 11(10):58–61

    PubMed  CAS  Google Scholar 

  16. Moore PA, Hersh EV, Papas AS, Goodson JM, Yagiela JA, Rutherford B et al (2008) Pharmaco kinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate. Anesth Prog 55(2):40–48

    Article  PubMed  Google Scholar 

  17. Poulet FM, Berardi MR, Halliwell W, Hartman B, Auletta C, Bolte H (2004) Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol 32(5):558–566

    Article  PubMed  CAS  Google Scholar 

  18. Hersh EV, Hermann DG, Lamp CJ, Johnson PD, Mac A, fee KA (1995) Assessing the duration of mandibular soft tissue anesthesia. J Am Dent Assoc 126(11):1531–1536

    PubMed  CAS  Google Scholar 

  19. Cooper BE (1989) High-dose phentolamine for extravasation of pressors. Clin Pharm 8(10):689

    PubMed  Google Scholar 

  20. Mc Cleane GJ (1996) Oral phentolamine mesylate in the treatment of complex regional pain Syndrome. Ulst Med J 65(1):87–88

    CAS  Google Scholar 

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Correspondence to J. S. Prasanna.

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Prasanna, J.S. OraVerse: Reverses Numbness After Dental Procedures. J. Maxillofac. Oral Surg. 11, 212–219 (2012). https://doi.org/10.1007/s12663-011-0318-6

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  • DOI: https://doi.org/10.1007/s12663-011-0318-6

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