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Hypercalcemia in patients of oral squamous cell carcinoma

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Purpose

This study was performed to measure the total and ionic serum calcium levels and incidence of hypercalcemia in patients with Oral Squamous Cell Carcinoma (OSCC) and its clinical significance and relevance.

Materials and methods

A randomly selected sample of seventy patients of histologically confirmed Oral Squamous Cell Carcinoma (OSCC) at any of the standard clinical stages were included. Fasting blood samples were obtained for measuring serum calcium levels. The elevated values of serum calcium levels were correlated with clinical features of hypercalcemia to draw inference.

Results

Total serum calcium was found to be elevated in 12 patients (17.4%) and serum ionic calcium was elevated in 3 patients (4.29%).

Conclusion

The data suggests that hypercalcemia occurred in advanced stages of oral squamous cell carcinoma and its management may be relevant in providing terminal care and prolonging the life span of the patients.

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References

  1. Myers WP (1960) Hypercalcemia in neoplastic disease. Arch Surg 80: 308–318

    CAS  PubMed  Google Scholar 

  2. Mundy GR, Martin TJ (1982) The hypercalcemia of malignancy: pathogenesis and management. Metabolism 31(12): 1247–1277

    Article  CAS  PubMed  Google Scholar 

  3. Ralston SH, Gallacher SJ, Patel U, et al. (1990) Cancer-associated hypercalcemia: morbidity and mortality. Clinical experience in 126 treated patients. Ann Intern Med 112(7): 499–504

    CAS  PubMed  Google Scholar 

  4. Glover DJ (1991) Hormone and Metabolic Manifestations of Tumor, Comprehensive Text Book of Oncology vol 2, ed 2, 1679–1683

  5. Won C, Decker DA, Drelichman A, Al-Sarraf M, Reed ML (1983) Hypercalcemia in head and neck carcinoma. Incidence and prognosis. Cancer 52(12): 2261–2263

    Article  CAS  PubMed  Google Scholar 

  6. Yoneda T, Nishimura R, Kato I, Ohmae M, Takita M, Sakuda M (1991) Frequency of the hypercalcemia-leukocytosis syndrome in oral malignancies. Cancer 68(3): 617–622

    Article  CAS  PubMed  Google Scholar 

  7. Lang-Kummer J. Hypercalcemia. In: Groenwald SL, Goodman M, Frogge MH, et al. (1997) eds.: Cancer Nursing: Principles and Practice. 4th ed. Sudbury, Mass: Jones and Bartlett Publishers 684–701

    Google Scholar 

  8. Carroll HF, Schade DS (2003) A practical approach to hypercalcemia. Am Fam Physician 67(9): 1959–1966

    PubMed  Google Scholar 

  9. Cramer SF, Fried L, Carter KJ (1981) The cellular basis of metastatic bone disease in patients with lung cancer. Cancer 48(12): 2649–2660

    Article  CAS  PubMed  Google Scholar 

  10. Penel N, Berthon C, Everard F, Nue JC, Clisant S, N’guyen M. et al. (2005) Prognosis of Hypercalcemia in aerodigestive tract cancer: study of 136 recent cases. Oral Oncol 41(9): 884–889

    Article  CAS  PubMed  Google Scholar 

  11. Ariyan CE, Sosa JA (2004) Assessment and management of patients with abnormal calcium. Crit Care Med 32(4 Suppl): S146–154

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Dept. of Oral and Maxillofacial Surgery, Datta Meghe Institute of Medical Sciences University, Wardha, India

    P. V. Nimonkar & R. M. Borle

  2. Dept. of Oral and Maxillofacial Surgery Faculty of Dentistry, Datta Meghe Institute of Medical Sciences University, Sawangi (M), Wardha, MS, India

    R. M. Borle

Authors
  1. P. V. Nimonkar
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  2. R. M. Borle
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Correspondence to R. M. Borle.

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Nimonkar, P.V., Borle, R.M. Hypercalcemia in patients of oral squamous cell carcinoma. J. Maxillofac. Oral Surg. 8, 230–232 (2009). https://doi.org/10.1007/s12663-009-0056-1

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  • DOI: https://doi.org/10.1007/s12663-009-0056-1

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