As artificial intelligence (AI) and biomedicine have intersected in recent years, a world of possibilities has now opened up that are revolutionizing healthcare and biomedical research. AI has rapidly become an essential tool in the biomedical field, offering innovative solutions to long-standing problems. With the advancements in computing power, sophisticated AI techniques have enabled the analysis of health data at scale. One of the most significant aspects of this field is the emergence of large language models and clinical foundation models.

Using these powerful AI tools to process vast amounts of structured and unstructured data has ushered in a new era of healthcare informatics. They excel at tasks such as the analysis of medical images, natural language understanding, and predictive analytics, making them invaluable for tasks ranging from electronic health record analysis and clinical decision support to drug discovery and the development of personalized treatment plans.

This special issue provides a glimpse into the many ways in which AI is shaping the future of biomedicine. Each contributing article emphasizes the potential of AI in enhancing precision and efficiency in healthcare, as well as inspiring a new aspect of discovery and innovation. It is our hope that as we navigate this evolving landscape, these advancements will continue to drive healthcare forward, making personalized, data-driven medicine an accepted standard of care.