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Pinhão Coat (Araucaria angustifolia (Bertol.) Kuntze) Nanosuspension as a Potential Additive in Cosmetic Formulations with Wound Healing Effect

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Abstract

Purpose

Development of a sustainable route to value pinhão (Araucaria angustifolia (Bertol.) Kuntze) coat through mechanical defibrillation process and employment as an additive in cosmetic formulations.

Methods

The pinhão coat nanosuspension (PCN) was added to the Lanette® base at concentrations of 0.5, 1.0, 1.5, and 2.0%. Subsequently, the PCN-based formulations were evaluated concerning their appearance, physiochemical aspects (pH, spreadability, and stability tests), rheological behavior, cytotoxicity, and wound closure capacity.

Results

The outcomes showed that the PCN addition conferred a light brown milky color to the lotions, besides decreasing the pH values and increasing the spreadability compared to the control formulations. Related to the rheological analysis, the lotions with PCN displayed pseudoplastic behavior, an aspect of strong gel, and were also stable through the thermomechanical analysis. The cell viability analysis showed no cytotoxicity of the PCN-based formulations at concentrations inferior to 0.05 mg/mL. Furthermore, the in vitro scratch wound assay revealed that the presence of PCN (1.5 and 2.0%) promoted a complete wound contraction after 72 h of treatment.

Conclusion

The study demonstrated a sustainable alternative to apply pinhão by-product in cosmetic formulation with wound-healing effects.

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Data Availability

The authors declare that all data supporting the findings of this study are available within the article and its supplementary information files.

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Funding

This study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001. Professors M.R. Mafra and L. Igarashi-Mafra are grateful to the Brazilian National Council for Scientific and Technological Development (CNPq—Grant 315667/2021–4 and 316815/2021–7, respectively).

Author information

Authors and Affiliations

  1. Department of Chemical Engineering, Polytechnic Center, Federal University of Paraná (UFPR), Curitiba, PR, 81531-990, Brazil

    Fernando Castro Leal, Karina Mayumi Ueda, Marcos R. Mafra & Luciana Igarashi-Mafra

  2. Materials Research Institute, Technological University of the Shannon: Midlands Midwest, Athlone, N37HD68, Ireland

    Tielidy Angelina de Morais de Lima

  3. Department of Pharmacy, Universidade Federal do Paraná (UFPR), Av. Pref. Lothário Meissner, 632, Curitiba, PR, 80210-170, Brazil

    Rilton Alves de Freitas

  4. Embrapa Forestry, Colombo, PR, 83410-000, Brazil

    Cristiane Vieira Helm & Washington Luiz Esteves Magalhães

Authors
  1. Fernando Castro Leal
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  2. Karina Mayumi Ueda
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  3. Tielidy Angelina de Morais de Lima
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  6. Washington Luiz Esteves Magalhães
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  7. Marcos R. Mafra
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  8. Luciana Igarashi-Mafra
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Contributions

Fernando Castro Leal: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing-original draft. Karina Mayumi Ueda: Formal analysis, Investigation, Methodology, Validation, Visualization, Writing-original draft. Tielidy Angelina Moraes de Lima: Methodology, Data curation, Formal analysis. Cristiane Vieira Helm: Resources; Investigation, Methodology, Validation. Rilton Alves de Freitas: Data curation; Methodology, Formal analysis, Visualization. Washington Luiz Esteves Magalhães: Investigation, Methodology, Validation, Visualization. Marcos R. Mafra: Project administration, Resources, Validation, Visualization, Writing-review & editing. Luciana Igarashi-Mafra: Conceptualization, Project administration, Resources, Software, Validation, Visualization, Funding acquisition, Writing-review & editing.

Corresponding author

Correspondence to Luciana Igarashi-Mafra.

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Leal, F.C., Ueda, K.M., de Morais de Lima, T.A. et al. Pinhão Coat (Araucaria angustifolia (Bertol.) Kuntze) Nanosuspension as a Potential Additive in Cosmetic Formulations with Wound Healing Effect. Waste Biomass Valor (2024). https://doi.org/10.1007/s12649-024-02427-1

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