, Volume 33, Issue 2, pp 185–190 | Cite as

Impedance Spectroscopy of Aqueous Solution Samples of Different Glucose Concentrations for the Exploration of Non-Invasive-Continuous-Blood-Glucose-Monitoring

  • Satish
  • Kushal Sen
  • Sneh Anand
Short Communication


Continuous blood-glucose-monitoring provides maximal information about the fluctuations of blood-glucose levels throughout the day and thus plays a vital role in controlling the blood-glucose level in diabetes. The conventional methods of testing blood-glucose level are invasive, painful and are unsuitable for continuous monitoring. Thus, the battle for developing bloodless and painless blood-glucose monitors has begun from past three decades. Electrical bio-impedance spectroscopy has been suggested as one of the potential technique for the development of such monitors. The present work is aimed at impedance spectroscopy to demonstrate the variation in electrical bio-impedance properties of blood with the change in glucose concentration. Glucose-dependent electrical impedance parameters of aqueous solution samples, of increasing glucose concentration have been determined to accomplish the same. The glucose-dependent capacitance and conductance illustrates the direct variations in impedance parameters with respect to change in glucose concentration. Measurement automation program is developed to ease the measurement procedure, to support continuous measurement, and to compute short-term repeatability of measurement results. The experimental results of the present work will be used to implement electrical bio-impedance spectroscopy technique in the development of non-invasive-continuous-blood-glucose monitoring system.


Non-invasive Diabetes Glucose concentration Electrical impedance Capacitance Conductance 



The authors would like to acknowledge the Director, IIT Delhi for the permission to publish the work. The authors are also grateful to the Director, CSIR-NPL, India for providing the infrastructure services required to perform the reported work. This work was supported by Science and Engineering Research Board, the Department of Science and Technology under Ministry of Science and Technology under Grant SB/EMEQ-023/2014.


  1. [1]
    International Diabetes Federation, IDF Diabetes Atlas, Seventh Edition. 2015.Google Scholar
  2. [2]
    S. K. Vashist, Non-invasive glucose monitoring technology in diabetes management: a review, Anal. Chim. Acta, 750 (2012) 16–27.CrossRefGoogle Scholar
  3. [3]
    A. Caduff, E. Hirt, Y. Feldman, Z. Ali and L. Heinemann, First human experiments with a novel non-invasive, non-optical continuous glucose monitoring system, Biosens. Bioelectron., 19 (2003) 209–217.CrossRefGoogle Scholar
  4. [4]
    I. M. E. Wentholt, J. B. L. Hoekstra, A. Zwart and J. H. DeVries, Pendra goes Dutch: Lessons for the CE mark in Europe, Diabetologia, 48 (2005) 1055–1058.CrossRefGoogle Scholar
  5. [5]
    A. Tura, S. Sbrignadello, S. Barison, S. Conti and G. Pacini, Impedance spectroscopy of solutions at physiological glucose concentrations, Biophys. Chem., 129 (2007) 235–41.CrossRefGoogle Scholar
  6. [6]
    Satish, K. Sen, S. Malik and S. Anand, Measurement of dielectric properties of ringer lactate solution with respect to D-glucose, IEEE international conference on electrical, computer and communication technologies (ICECCT), 2015.Google Scholar
  7. [7]
    Satish, K. Sen and S. Anand, Determination of glucose-dependent dielectric properties of ringer lactate using open-ended coaxial probe method. MAPAN-J. Metrol. Soc. India, 31 (2016) 225–230.Google Scholar
  8. [8]
    Satish, N. Sawhney, S. Kumar and A. K. Saxena, Evaluation of three terminal capacitance standards at CSIR-NPL, MAPAN-J. Metrol. Soc. India, 30 (2015) 261–265.Google Scholar
  9. [9]
    Satish, Babita, B. Khurana, S. Kumar and A. K. Saxena, Evaluation of four-terminal-pair capacitance standards using electrical equivalent circuit model. Measurement, 73 (2015) 121–126.CrossRefGoogle Scholar
  10. [10]
    S. Singh, S. Kumar, Babita, and T. John, Realization of four-terminal-pair capacitors as reference standards of impedance at high frequency using impedance-matrix method, IEEE Trans. Instrum. Meas., 66 (2017) 2129–2135.CrossRefGoogle Scholar
  11. [11]
    Satish, Babita, B. Khurana, and T. John, Measurement automation to implement evaluation procedure of four-terminal-pair capacitance standards using S-parameters, MAPAN-J. Metrol. Soc. India, 32 (2017) 175–181.Google Scholar
  12. [12]
    S. Kumar, Babita, T. John, Evaluation of air dielectric four-terminal-pair capacitance standards using resonance frequency of impedance elements. Measurement, 100 (2017) 176–182.CrossRefGoogle Scholar
  13. [13]
    Satish, S. Kumar, Babita, T. John and A. K. Saxena, Realization of coaxial reference air-lines as high frequency capacitance standard at CSIR-NPL. Measurement, 92 (2016) 66–171.CrossRefGoogle Scholar
  14. [14]
    Agilent 16048A Test Leads Operation and Service Manual. (2000).Google Scholar
  15. [15]
    B. Ehtesham, P. S. Bist and T. John, Development of an automated precision direct current source for generation of pA currents based on capacitance charging method at CSIR-NPL, MAPAN-J. Metrol. Soc. India, (2016) 1–6.Google Scholar
  16. [16]
    Satish, M. A. Ansari and A. K. Saxena, Determination and comparison of temperature coefficient of standard inductors by measuring change in inductance and resistances, MAPAN-J. Metrol. Soc. India, 29 (2014) 73–76.Google Scholar
  17. [17]
    V. N. Ojha, A. Singh, S. K. Jaiswal and S. K. Sharma, Automatic and manual calibration of high precision multifunction calibrator, MAPAN-J. Metrol. Soc. India, 18 (2003) 43–48.Google Scholar

Copyright information

© Metrology Society of India 2017

Authors and Affiliations

  1. 1.Centre for Biomedical Engineering, Indian Institute of TechnologyNew DelhiIndia
  2. 2.LF, HF Impedance and DC MetrologyCSIR-National Physical LaboratoryNew DelhiIndia
  3. 3.Department of Textile TechnologyIndian Institute of TechnologyNew DelhiIndia

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