Abstract
Alzheimer's disease (AD) is a central disease with high incidence, and its pathological process is closely associated with changes of some biological indicators in the periphery. Among them, the intestinal flora mainly causes a series of pathological changes such as inflammation through the immune system, which may contribute to the pathological process of AD. In this paper, we mainly focused the relationship between gut microbiota and immune system disorder in the neuropathology of AD, underlining the significance of the advanced mechanism of inflammatory response and providing a new direction for the treatment of AD.
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This work was supported by the Research and Development Fund Project of Kangda College, Nanjing Medical University (No. KD2019KYJJZD018).
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JS, JC and QL came up with ideas and wrote the manuscript. JZ, ZY and TW helped in reviewing the manuscript and polishing language. All authors read and approved this manuscript.
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Chen, J., Li, Q., Zhu, J. et al. GPR40 Agonist Ameliorate Pathological Neuroinflammation of Alzheimer’s Disease via the Modulation of Gut Microbiota and Immune System, a Mini-Review. Neurotox Res 39, 2175–2185 (2021). https://doi.org/10.1007/s12640-021-00408-z
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DOI: https://doi.org/10.1007/s12640-021-00408-z