Abstract
Increased circulating intercellular adhesion molecule 3 (ICAM3) is associated with a risk of acute ischemic stroke. This study aims to investigate the association of serum levels of ICAM3 with the severity and short-term outcomes of ischemic stroke. This study recruited 152 stroke patients with supratentorial cerebral infarcts and 133 healthy controls. Patients were followed up for 2 weeks since admission for observation of functional outcomes. Serum ICAM3 concentrations at baseline were determined by Elisa. Serum ICAM3 concentrations were higher in stroke patients than in healthy controls. Serum concentrations of ICAM3 were not associated with stroke severity at baseline, as reflected by NIH Stroke Scale (NIHSS) and infarction volume. However, serum ICAM3 levels were positively associated with mRS scores at 2 weeks since admission. Furthermore, regression analyses found that increased serum ICAM3 levels were associated with worse short-term functional outcomes of stroke. These findings imply that circulating ICAM3 might be a potential short-term prognostic biomarker for acute ischemic stroke.
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References
Baerts L et al (2017) Acute ischemic stroke severity, progression, and outcome relate to changes in dipeptidyl peptidase IV and fibroblast activation protein activity. Transl Stroke Res 8:157-164. https://doi.org/10.1007/s12975-016-0493-3
Bonita R, Beaglehole R (1988) Recovery of motor function after stroke. Stroke 19:1497–1500. https://doi.org/10.1161/01.str.19.12.1497
Campanero MR, Sanchez-Mateos P, del Pozo MA, Sanchez-Madrid F (1994) ICAM-3 regulates lymphocyte morphology and integrin-mediated T cell interaction with endothelial cell and extracellular matrix ligands. J Cell Biol 127:867-878. https://doi.org/10.1083/jcb.127.3.867
de Fougerolles AR, Springer TA (1992) Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes. J Exp Med 175:185-190. https://doi.org/10.1084/jem.175.1.185
Goldstein LB, Samsa GP (1997) Reliability of the National Institutes of Health Stroke Scale. Extension to non-neurologists in the context of a clinical trial. Stroke 28:307–310. https://doi.org/10.1161/01.str.28.2.307
Griffiths CE, Boffa MJ, Gallatin WM, Martin S (1996) Elevated levels of circulating intercellular adhesion molecule-3 (cICAM-3) in Psoriasis. Acta Derm Venereol 76:2-5. https://doi.org/10.2340/000155557625
Hachim MY, Ahmed AH (2006) The role of the cytokines and cell-adhesion molecules on the immunopathology of acute appendicitis. Saudi Med J 27:1815–1821
Ibeas E, Fuentes L, Martin R, Hernandez M, Nieto ML (2009) Secreted phospholipase A2 type IIA as a mediator connecting innate and adaptive immunity: new role in atherosclerosis. Cardiovasc Res 81:54-63. https://doi.org/10.1093/cvr/cvn234
Jung YH, Kim YD, Kim J, Han SW, Oh MS, Lee JS, Lee KY (2020) Initial stroke severity in patients with atrial fibrillation according to antithrombotic therapy before ischemic stroke. Stroke 51:2733–2741. https://doi.org/10.1161/STROKEAHA.120.030138
Monach PA et al (2011) Circulating markers of vascular injury and angiogenesis in antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 63:3988–3997. https://doi.org/10.1002/art.30615
Perrin EM et al (2018) Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. Pediatr Res 83:1110-1119. https://doi.org/10.1038/pr.2017.313
Pletsch-Borba L et al (2020) Vascular injury biomarkers and stroke risk: a population-based study. Neurology 94:e2337–e2345. https://doi.org/10.1212/WNL.0000000000009391
Soilleux EJ, Morris LS, Trowsdale J, Coleman N, Boyle JJ (2002) Human atherosclerotic plaques express DC-SIGN, a novel protein found on dendritic cells and macrophages. J Pathol 198:511-516. https://doi.org/10.1002/path.1205
Stanne TM et al (2016) Low circulating acute brain-derived neurotrophic factor levels are associated with poor long-term functional outcome after ischemic stroke. Stroke 47:1943–1945. https://doi.org/10.1161/STROKEAHA.115.012383
Torr EE et al (2012) Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells. Cell Death Differ 19:671-679. https://doi.org/10.1038/cdd.2011.167
Wang W et al (2017) Prevalence, incidence, and mortality of stroke in China: results from a nationwide population-based survey of 480 687 adults. Circulation 135:759-771. https://doi.org/10.1161/CIRCULATIONAHA.116.025250
Funding
This study was supported by National Nature Science Foundation of China (No 81860250 to YX and No. 81801711 to STT).
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HZC and STT designed the study and drafted the manuscript; YX, HRZ, LYY, and RHT collected the samples and analyzed the data. HZC and YX supervised the project. HRZ and LYY were responsible for the clinical assessment of subjects.
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This study was approved by the investigational review board of the General Hospital, Ningxia Medical University, and the Second Affiliated Hospital of Chongqing Medical University.
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Zicheng, H., Xiao, Y., Rongzhong, H. et al. Association of Circulating ICAM3 Concentrations with Severity and Short-term Outcomes of Acute Ischemic Stroke. Neurotox Res 39, 1293–1299 (2021). https://doi.org/10.1007/s12640-021-00372-8
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DOI: https://doi.org/10.1007/s12640-021-00372-8