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Serum Aβ Levels are Associated with Age-related Cataract

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Abstract

To investigate the levels and clinical relevance of serum β-amyloid (Aβ) in age-related cataract (ARC) patients. In the present study, an overall of 402 ARC patients and 450 normal controls were recruited between June 2018 and December 2019. Serum Aβ1-40 and Aβ1-42 concentrations were assessed by Elisa. The ARC patients were further grouped into several subgroups according to gender, age, types of ARC, and degree of lens opacity. The association of Aβ levels with ARC was determined using logistic regression models. ARC patients had significantly higher serum Aβ1-40 and Aβ1-42 levels than normal control. A similar finding was observed in subjects aged over 60 years. Serum Aβ concentrations were significant correlated with the degrees of lens opacity in C-ARC and N-ARC subjects. Logistic regression analyses revealed that serum Aβ1-40 (ORs = 1.202, 95% CI 1.077 to 1.341) and Aβ1-42 (ORs = 1.686, 95% CI 1.351 to 2.103) levels were potential risk factors for ARC. ARC patients have higher serum Aβ1-40, as well as Aβ1-42 levels, which may reflect an association between Aβ and ARC pathogenesis. Serum Aβ1-42 and Aβ1-40 levels are potential risk factors for ARC.

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Acknowledgments

This work was supported by grant No.81700824 National Natural Science Foundation of China (NSFC). Thanks are due to Yeran Wang for valuable advice and guidance.

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Authors and Affiliations

  1. Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, 400042,, China

    Chongyi Li, Zhao Geng, Zhiqiang Wang & Jian Ye

  2. Caner Center, Daping Hospital, Third Military Medical University, Chongqing, 400042,, China

    Bo Yang & He Xiao

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  1. Chongyi Li
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  2. Zhao Geng
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  3. Bo Yang
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  4. He Xiao
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  5. Zhiqiang Wang
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  6. Jian Ye
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Correspondence to Jian Ye.

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Li, C., Geng, Z., Yang, B. et al. Serum Aβ Levels are Associated with Age-related Cataract. Neurotox Res 39, 369–377 (2021). https://doi.org/10.1007/s12640-020-00325-7

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  • DOI: https://doi.org/10.1007/s12640-020-00325-7

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