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Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants

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Abstract

Neurodegenerative diseases account for a significant portion of public health concerns particularly in the aging population. The dysfunction of interfilament proteins has been identified as a key event in the initiation of neurodegeneration and subsequent progression to neurodegenerative diseases. In addition, several studies have found associations between the dysfunction of interfilament proteins and exposure to environmental contaminants. Therefore, in this review, the role of interfilament proteins in neuronal cells, their connection to neurotoxicity from environmental contaminants, and finally the resulting neurodegeneration are discussed.

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  1. Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, TX, Lubbock, USA

    Odia Osemwegie, Seshadri Ramkumar & Ernest E. Smith

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  1. Odia Osemwegie
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Osemwegie, O., Ramkumar, S. & Smith, E.E. Neurodegenerative Implications of Neuronal Cytoplasmic Protein Dysfunction in Response to Environmental Contaminants. Neurotox Res 39, 533–541 (2021). https://doi.org/10.1007/s12640-020-00308-8

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