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The Role of HINT1 in Methamphetamine-Induced Conditioned Place Preference

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Abstract

Drug addiction is a chronically relapsing disorder in humans; yet, the underlying mechanism remained unclear. Recent studies suggested that the histidine triad nucleotide binding protein 1 (HINT1) may play significant roles in diverse neuropsychiatric diseases including drug addiction. In our present study, we used different batches of mice to establish the different stages of methamphetamine (METH)-induced conditioned place preference (CPP) to explore the dynamic changes throughout the process of addiction in different brain regions, including prefrontal cortex (PFC), nucleus accumbens (NAc), corpus striatum (CPu), and hippocampus (Hip). We found that in NAc of the METH group mice, the HINT1 expression level initially increased after acquisition phases, and then dropped to the normal level after extinction phase, and again increased after reinstatement phase. However, there was no statistical difference in the HINT1 expression level in other three encephalic regions (PFC, CPu, and Hip). Therefore, the HINT1 protein, particularly in the NAc, plays a vital role in the METH-induced CPP. However, the precise mechanisms will require further investigation.

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Acknowledgements

This research was supported by the National Science Foundation of China (NSFC81171262, 81771435, 81371473 to Yong-hui Dang), and the Natural Science Basic Research Plan in Shaanxi Province of China (No. 2016JM8078 to Yong-hui Dang).

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Author notes

  1. Ju-ping Li and Peng Liu contributed equally to this study

Authors and Affiliations

  1. College of Medicine and Forensics, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, 710061, People’s Republic of China

    Ju-ping Li, Peng Liu, Gang Lei, Zheng Chu, Fei Liu, Yong-hui Dang & Teng Chen

  2. Institute of law, Northwest University of Political Science and Law, Xi’an, Shaanxi, People’s Republic of China

    Ju-ping Li

  3. Affiliated Stomatology Hospital of Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China

    Fei Liu

  4. Institute of Material Evidence Identification, Kaifeng Municipal Public Security Bureau, Kaifeng, Henan, People’s Republic of China

    Chao-feng Shi

  5. Key Laboratory of the Health Ministry for Forensic Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China

    Yong-hui Dang & Teng Chen

  6. Key Laboratory of Forensic Medicine of Shaanxi Province, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, People’s Republic of China

    Yong-hui Dang & Teng Chen

Authors
  1. Ju-ping Li
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  2. Peng Liu
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  3. Gang Lei
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  7. Yong-hui Dang
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  8. Teng Chen
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Corresponding authors

Correspondence to Yong-hui Dang or Teng Chen.

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The experimental protocol was approved by the Institutional Animal Care Committee of Xi’an Jiaotong University.

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Li, Jp., Liu, P., Lei, G. et al. The Role of HINT1 in Methamphetamine-Induced Conditioned Place Preference. Neurotox Res 33, 353–361 (2018). https://doi.org/10.1007/s12640-017-9797-7

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  • DOI: https://doi.org/10.1007/s12640-017-9797-7

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