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Serum Copeptin Predicts Severity and Recurrent Stroke in Ischemic Stroke Patients

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Abstract

Several studies investigated the prognostic role of copeptin in stroke. The aim of this study is to assess copeptin levels in serum, and investigate their associations with risk of recurrent stroke in a 1-year follow-up study in patients with ischemic stroke. In this post hoc analysis, serum levels of copeptin and NIH stroke scale (NIHSS) were measured at the time of admission in a cohort of 316 patients with ischemic stroke. The end point was stroke recurrence after 1-year follow-up. We used logistic regression model to assess the relationship between copeptin levels and risk recurrent stroke. Logistic regression analysis considering traditional risk factors showed a relationship between serum copeptin levels and moderate-to-high clinical severity when serum copeptin was used as a continuous variable (OR, 1.05; 95% CI, 1.03–1.09). In the follow-up, 54 patients (17.1%) had a stroke recurrence. The stroke recurrence events distribution across the copeptin quartiles ranged between 5.1% (first quartile) to 23.1% (fourth quartile). In multivariate models comparing the third (OR = 2.78; 95% CI 1.85–3.53) and fourth quartiles (OR = 4.00; 95% CI 2.86–6.50) against the first quartile of the copeptin, levels of copeptin were associated with stroke recurrence events. A higher serum copeptin level is a predictor of both severity at admission and stroke recurrence at 1-year in stroke patients.

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Acknowledgements

This study was supported by National Natural Science Foundation of China (81400330). We express our gratitude to all the patients who participated in this study, and thereby made this work possible.

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Authors and Affiliations

  1. Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China

    Wan-Zhong Tang & Huan-Ting Li

  2. Department of Geriatrics and Shandong Key Laboratory of Proteomics, Qilu Hospital of Shandong University, 107 Wenhuaxi, Road, Jinan, Shandong Province, 250012, China

    Xiao-Bo Wang & Xiang Ji

  3. Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China

    Mei Dong

Authors
  1. Wan-Zhong Tang
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  2. Xiao-Bo Wang
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  3. Huan-Ting Li
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  4. Mei Dong
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  5. Xiang Ji
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Contributions

Ji had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Tang, Wang, Li, Dong, and Ji.

Acquisition of data: Tang, Wang, and Ji.

Analysis and interpretation of data: Tang, Li, and Dong.

Drafting of the manuscript: Tang and Ji.

Critical revision of the manuscript for important intellectual content: Wang, Li, and Dong.

Administrative, technical, or material support: Tang, Wang, and Li.

Study supervision: Li.

Corresponding author

Correspondence to Xiang Ji.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Statement

The present study has been approved by the ethics committee of the Qilu Hospital of Shandong University. All participants or their relatives were informed of the study protocol, and their written informed consents were obtained.

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Tang, WZ., Wang, XB., Li, HT. et al. Serum Copeptin Predicts Severity and Recurrent Stroke in Ischemic Stroke Patients. Neurotox Res 32, 420–425 (2017). https://doi.org/10.1007/s12640-017-9754-5

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  • DOI: https://doi.org/10.1007/s12640-017-9754-5

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