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The impact of anthelminthic therapeutics on serological and tissues apoptotic changes induced by experimental trichinosis

Abstract

Trichinosis is a sharable parasitic disease caused by Trichinella spp., the disease occurred on eating inappropriate cooked pork infected by the parasite encysted larvae. This study aimed to evaluate experimentally the impact of treatment by thiabendazole, praziquantel (PZQ) and prednisone on T. spiralis induced parasitological, serological and apoptotic changes. Forty albino rats were infected orally each by ± 1000 larvae, divided into four groups each of 10 rats, group (A) infected control, group (B) thiabendazole tested, group (C) PZQ tested and group (D) prednisone tested. On the seventh and 40th days post-infection, all groups were evaluated parasitologically by the number of the intestinal worms and the muscular encysted larvae, while IFN-γ and TNF-α were estimated by ELISA, histopathological and histochemical assessment of the tissue changes during both phases were performed by different stains. In conclusion, thiabendazole was a potent and curable drug, it showed nearly 100% efficacy on intestinal worms, highly significant variations in cytokines levels during both the intestinal and muscular phases, while it induced moderate effects on encysted muscular larvae number, In addition it ameliorated myocytes apoptotic changes induced by trichinosis.

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Correspondence to Sara A. Abdel-Rahman.

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Etewa, S.E., Fathy, G.M., Abdel-Rahman, S.A. et al. The impact of anthelminthic therapeutics on serological and tissues apoptotic changes induced by experimental trichinosis. J Parasit Dis 42, 232–242 (2018). https://doi.org/10.1007/s12639-018-0990-2

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  • DOI: https://doi.org/10.1007/s12639-018-0990-2

Keywords

  • Trichinella spiralis
  • Thiabendazole
  • Praziquantel
  • Prednisone
  • IFN-γ
  • TNF-α
  • Apoptotic changes