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Antimalarial activity of Artemisia nilagirica against Plasmodium falciparum

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Abstract

Malaria is one of the most prevalent vector borne infectious disease and a serious global health problem in the world. Treatment for malaria is commonly inadequate due to the lack of quality assured limited number of effective drugs, underline how important it is to discover new antimalarial plants from number of natural sources. In the present study, the efficacy of antimalarial activity was studied by taking six various (n-hexane, chloroform, petroleum ether, ethanol, methanol and aqueous) organic leaf extracts of Artemisia nilagirica (Clarke) Pamp. against malarial parasite Plasmodium falciparum. Promising antiplasmodial activity was found in all tested extracts; however, maximum 50% inhibitory concentration (IC50) values were noticed after 32 h of incubation, which is 5.76 ± 0.82, 7.09 ± 1.09, 9.88 ± 1.13, 10.24 ± 1.52, 11.37 ± 1.77 and 50.15 ± 6.16 µg/ml in methanol, chloroform, n-hexane, petroleum ether, ethanol and aqueous extracts, respectively. In conclusion, A. nilagirica leaf extract possesses antiplasmodial activity which may be used as a potent plant-based antimalarial drug in the future by investigating the hidden phytochemical/(s).

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Acknowledgements

The authors like to thank Director, ICMR-Regional Medical Research Centre, Bhubaneswar for providing laboratory facility. This work is financially supported by SAP-DRS-III Programme of UGC, New Delhi, India.

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Authors and Affiliations

  1. Biochemistry and Molecular Biology Laboratory, Post Graduate Department of Botany, Utkal University, Vani Vihar, Bhubaneswar, Odisha, 751004, India

    Sagorika Panda, Jyoti Ranjan Rout & Santi Lata Sahoo

  2. Molecular Epidemiology, ICMR-Regional Medical Research Centre, Chandrasekharpur, Bhubaneswar, Odisha, 751023, India

    Pallabi Pati & Manoranjan Ranjit

  3. Department of Biotechnology, Academy of Management and Information Technology, 67/68, IID Centre, Bidya Vihar, Barunei Hills, Khurda, Odisha, 752057, India

    Jyoti Ranjan Rout

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  1. Sagorika Panda
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  2. Jyoti Ranjan Rout
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  5. Santi Lata Sahoo
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Correspondence to Santi Lata Sahoo.

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The authors declare that they have no conflict of interest.

Ethical approval statement

The experimental aims and protocol were explained to the director and head of molecular epidemiology of RMRC, Bhubaneswar. Informed consent was obtained from all of the individual patients that were included in the study.

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Panda, S., Rout, J.R., Pati, P. et al. Antimalarial activity of Artemisia nilagirica against Plasmodium falciparum . J Parasit Dis 42, 22–27 (2018). https://doi.org/10.1007/s12639-017-0956-9

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  • DOI: https://doi.org/10.1007/s12639-017-0956-9

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