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Biology of Trypanosoma (Trypanozoon) evansi in experimental heterologous mammalian hosts

Journal of Parasitic Diseases volume 40, pages 1047–1061 (2016)Cite this article

Abstract

Trypanosoma (Trypanozoon) evansi is a causative agent of the dreadful mammalian disease trypanosomiasis or ‘Surra’ and carried as a latent parasite in domestic cattle but occasionally proves fatal when transmitted to horses and camel. Sporadic outbreak of ‘Surra’ to different animals (beside their natural hosts) reminds that T. evansi may be zoonotic, as their close relative cause sleeping sickness to human being. This haemoflagellate is mechanically transmitted by horse fly and its effect on different host varies depending on certain factors including the effectiveness of transmission by mechanical vector, the suitability and susceptibility of the host as well as most importantly the ability of the disease establishment of parasite to adapt itself to the host’s resistance, etc. The course of the disease caused by T. evansi is similar to that of human sleeping sickness caused by T. (T.) brucei gambiense. The target organs and symptoms show close similarity. T. evansi can successfully be transmitted among unnatural hosts i.e., other classes of vertebrates, like chicken. In transmission experiments, the unnatural hosts may sometimes induce profound changes in the biology of trypanosomes. Hence, in present study the observations are the biology of different morphological changes of T. evansi as well as its ability of disease formation within some heterologous mammal viz., albino rat, guineapig, bandicoot, mongoose, domestic cat and common monkey. Blood smears of infected albino rats, bandicoot, and mongoose revealed only monomorphic form. Interestingly, blood smears of infected cat and monkey, T. evansi shows slender trypomastigote form and short intermediate form whereas organ smears shows other two forms of haemoflagellate viz., sphaeromastigote and amastigote form. The haemoflagellate maintains a common reproductive cycle in all the experimental heterologous hosts whereas disease symptoms differ. T. evansi infected cat and monkey shows nervous symptoms. Infected monkey expresses some symptoms similar to that of human sleeping sickness disease. Thus the paper highlights zoonotic potentialities of T. evansi.

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Acknowledgments

The authors are thankful to the Head of the Department of Zoology, University of Calcutta for necessary laboratory facilities. The author (KKM) pays his gratefulness to the Principal, R. B. C. College, Naihati for this work.

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Author notes

  1. K. K. Misra

    Present address: Department of Zoology, Asutosh College, Kolkata, India

Affiliations

  1. Department of Zoology, R. B. C. College, Naihati, India

    K. K. Misra

  2. City College, Kolkata, India

    S. Roy

  3. University of Calcutta, Kolkata, India

    A. Choudhury

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  1. K. K. Misra
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  3. A. Choudhury
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Correspondence to K. K. Misra.

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Misra, K.K., Roy, S. & Choudhury, A. Biology of Trypanosoma (Trypanozoon) evansi in experimental heterologous mammalian hosts. J Parasit Dis 40, 1047–1061 (2016). https://doi.org/10.1007/s12639-014-0633-1

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Keywords

  • Bandicoot rat
  • Cat
  • Monkey
  • Pleomorphic forms
  • Surra
  • Trypanosoma evansi
  • Zoonosis