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Journal of Parasitic Diseases

, Volume 39, Issue 4, pp 663–672 | Cite as

Herbal extract targets in Leishmania tropica

  • Bassim I. Mohammad
  • Maani N. Al Shammary
  • Roaa H. Abdul Mageed
  • Nasser Ghaly Yousif
Original Article

Abstract

The present study aims to investigate the effect of some herbal extract such as phenolic compounds on the viability of Leishmania tropica promastigotes in vitro. Four tested chemical agents (caffeic acid (CA), ferulic acid (FA), syringic acid (SA) and 4-hydroxybenzoic acid (4-HBA)) were used in this study. The viability of Leishmania tropica promastigotes was investigated under five different concentrations (10, 15, 20, 25 and 30 mg/ml) of each agent after (72 h). CA was the most active agent on the promastigotes viability after 72 h exposure to 30 mg/ml concentration so that the parasiticidal effect reach (53 × 104) promastigote/ml. FA is the second agent in parasiticidal effect that parasiticidal effect reach to (50 × 104 promastigote/ml) at a concentration (30 mg/ml), 4-HBA is the third agent in parasiticidal effect that reach to (48 × 104 promastigote/ml) at a concentration (30 mg/ml), SA is the weakest agent in parasiticidal activity that reach to (44 × 104 promastigote/ml) at a concentration (30 mg/ml). It can be concluded that (CA, FA, SA and 4-HBA) possess acidal effect on the Leishmania tropica promastigotes in vitro.

Keywords

Leishmania tropica promastigotes Phenolic compounds Parasiticidal effect Sodium stibogluconate 

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Copyright information

© Indian Society for Parasitology 2014

Authors and Affiliations

  • Bassim I. Mohammad
    • 1
  • Maani N. Al Shammary
    • 3
  • Roaa H. Abdul Mageed
    • 4
  • Nasser Ghaly Yousif
    • 1
    • 2
  1. 1.College of PharmacyUniversity of Al QadisiyahAl DiwaniyahIraq
  2. 2.Department of Surgery and InflammationColorado UniversityAuroraUSA
  3. 3.College of MedicineUniversity of Al QadisiyahAl DiwaniyahIraq
  4. 4.Ministry of agriculture, Al Diwaniyah directorateAl DiwaniyahIraq

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