Supplemente haben im Anti-Aging-Bereich von Beginn an eine große Rolle gespielt. Im Vordergrund standen dabei lange Zeit antioxidative Wirkstoffe. Inzwischen ist unser Bild des biologischen Alterungsprozesses jedoch sehr viel differenzierter geworden. Entsprechend vielfältiger sind heute auch die Möglichkeiten einer Supplementierung.
Literatur
López-Otín C et al. The Hallmarks of Aging. Cell. 2013; 153: 1194–217
Harman D. Aging: A theory based on free radical and radiation chemistry. J Gerotol. 1956; 11: 298–300
Alpha-Tocopherol, Beta Carotine Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New Engl J Med. 1994; 330: 1029–35
Miller ER et al. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005; 142: 37–46
Ambati RR et al. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications — a review. Mar Drugs. 2014; 12: 128–52
Aoi W et al. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid Redox Signal. 2003; 5: 139–44
Piermarocchi S et al. Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study. Eur J Ophthalmol. 2012; 22: 216–25
Ross R. The pathogenesis of arterosclerosis: a perspective to the 1990s. Nature. 1993; 362: 801–9
Franceschi C et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000; 908: 244–54
Fürst R, Zündorf I. Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress. Mediators Inflamm. 2014; 2014: 146832
Zhu Y et al. The Achilles heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015; 14: 644–58
Rubinsztein DC et al. Autophagy and aging. Cell. 2011; 146: 682–95
Nixon RA. The role of autophagy in neurodegenerative disease. Nat Med. 2013; 19: 983–97
Hall JA et al. The sirtuin family’s role in aging and age-associated pathologies. J Clin Invest. 2013; 123: 973–9
Britton RG et al. Direct molecular targets of resveratrol: identifying key interactions to unlock complex mechanism. Ann N Y Acad Sci. 2015; 1348: 124–33
Gupta SC et al. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013; 15: 195–218
Blackburn EH et al. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 2006; 12: 1133–8
Fu J et al. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res. 2014; 28: 1275–83
Salvador L et al. A natural product telomerase activator lengthens telomerase in humans: a randomized, double blind, and placebo controlled study. Rejuvenation Res. 2016; 19: 478–84
Ma H et al. Shortened Telomere length is associated with increased risk of cancer: A Meta-Analysis. PLoS One. 2011; 6: e20466
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kleine-Gunk, B. Anti-Aging und Nahrungssupplemente — die nächste Generation. ästhet dermatol kosmetol 11, 30–33 (2019). https://doi.org/10.1007/s12634-019-0112-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12634-019-0112-x