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Hydroxyl Radical Scavenging of Liquid Silicone Rubber/Ce0.5Zr0.5O2 Nanocomposites for Local Delivery of Antioxidants to Control Oxidative Stress Induced Damages

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Abstract

Local administration of drug effectively following cochlear implantation is highly challenging, which imposes limitations such as insufficient drug, poor distribution and need for additional surgical procedures. Recent research is focused on integrating the drug with the silicone encasing of the electrode in cochlear implanted patients to overcome these limitations. The objective of the study is to assess the delivery of Ce0.5Zr0.5O2 antioxidant through silicone encasing and the suitability of the nanocomposites as an electrode encasing material. The proposed strategy is expected to overcome the issues associated with poor dispersion stability of the Ce0.5Zr0.5O2 based nanofluid and its corresponding long term effect, while utilizing its regenerative ability. Liquid silicone rubber (LSR)/Ce0.5Zr0.5O2 nanocomposites are prepared and characterized using suitable techniques. The reinforcement of nanoparticles up to 5 wt.% did not affect the modulus and electrical conductivity significantly. The hydroxyl radicals are scavenged by 36% in artificial perilymph fluid. The Ce3+ concentration is reduced from 45 to 9% after adding H2O2 and then it is regenerated to 35% after 13 days due to its ability to switch between Ce3+ and Ce4+. From this study, LSR/ Ce0.5Zr0.5O2 nanocomposites are proposed as electrode encasing material inside cochlea for scavenging hydroxyl radicals and its regeneration potential.

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The data are available from the corresponding author upon request.

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Acknowledgements

The authors acknowledge the contribution from Central Instrument Facility, IIT Guwahati, for UTM and XPS instruments. The authors acknowledge the support provided by North East Centre for Biological Sciences and Healthcare Engineering (NECBH), IIT Guwahati (BT/COE/34/SP28408/2018).

Funding

The authors acknowledge the kind financial support by Department of Biotechnology, (Sanction Number BT/PR16998/NER/95/449/2015, Project Title: Preservation of residual hearing by localized delivery of nanoceria based solid solution and composite as an antioxidant in cochlear implants), Government of India.

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  1. Biomedical Devices and Biomaterials Laboratory, Department of Mechanical Engineering, Indian Institute of Technology, Guwahati, Assam, 781039, India

    Nandani Rai & S. Kanagaraj

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  1. Nandani Rai
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Correspondence to S. Kanagaraj.

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Rai, N., Kanagaraj, S. Hydroxyl Radical Scavenging of Liquid Silicone Rubber/Ce0.5Zr0.5O2 Nanocomposites for Local Delivery of Antioxidants to Control Oxidative Stress Induced Damages. Silicon 16, 2497–2508 (2024). https://doi.org/10.1007/s12633-024-02845-9

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