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Design, Synthesis, Drug-Likeness and In Silico Prediction of Polycyclic Aromatic Schiff base Tethered Organosilatranes

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Abstract

The present article includes the generation of aromatic Schiff base tethered organosilatranes via two step synthetic pathways starting from anthracene-10-carbaldehyde and 1H-indole-3-carbaldehyde. The synthesis was achieved by employing condensation reaction followed by transesterification methodology. The prepared organosilatranes containing aromatic schiff based ligands were structurally authenticated using spectroscopic techniques such as FT-IR, NMR and mass analysis. The prepared compounds were also scrutinized for in silico physiochemical properties via Molininspiration and ADMET software and the results revealed their good biological potential for drug discovery.

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Acknowledgements

The authors are thankful to CSIR and DST-PURSE for giving financial assistance.

Funding

CSIR and DST-PURSE have given fund for carrying out the research.

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Authors and Affiliations

  1. Department of Chemistry, Panjab University, Chandigarh, 160014, India

    Gurjaspreet Singh,  Shilpy,  Sushma,  Mohit, Yamini Thakur & K. N. Singh

  2. Department of Chemistry, DAV College, Sector 10, Chandigarh, 160011, India

    Akshpreet Singh

  3. University Institute of Engineering & Technology, Panjab University, Chandigarh, India

    Surjeet Singh

  4. Department of Chemistry, GGDSD College, Sector 32, Chandigarh, India

    Sajeev Soni

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  1. Gurjaspreet Singh
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  2. Shilpy
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  6. Mohit
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  8. K. N. Singh
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Contributions

Gurjaspreet Singh: Supervision, Project administration

Shilpy: Conceptualization, Investigation

Akshpreet Singh: Methodology

Surjeet Singh: Writing—Original Draft

Sushma: Writing—Review & Editing

Mohit: Data Curation

Yamini Thakur: Resources

K.N Singh: Validation

Sajeev Soni: Visualization

Corresponding author

Correspondence to Gurjaspreet Singh.

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Singh, G., Shilpy, Singh, A. et al. Design, Synthesis, Drug-Likeness and In Silico Prediction of Polycyclic Aromatic Schiff base Tethered Organosilatranes. Silicon 15, 867–873 (2023). https://doi.org/10.1007/s12633-022-02062-2

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  • DOI: https://doi.org/10.1007/s12633-022-02062-2

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