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Fabrication of effective mesoporous silica materials for emergency hemostasis application

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Abstract

Uncontrolled bleeding is an important cause of traumatic death in wartime and peacetime. Despite the significant advances in hemostatic research, it is still challenging to develop safer and more effective hemostatic agents or dressings for emergency hemostasis application. Herein, we present a mesoporous silica particle (MSP) with large mesopores (12 nm around) through a facile and relative mild approach using dual silica source. The whole blood clotting time of MSP was about 23.13% shorter than that of Celox™ Granules (chitosan powder, a famous hemostatic agent) in vitro. To further facilitate the practical use in emergency hemostasis, MSP was fixed on cotton fibers by in-situ synthesis to form the composites of mesoporous silica-cotton (MS-C). The mass fraction of mesoporous silica reached 12.05% in MS-C, and the MSP are firmly anchored onto the cotton surface with < 5% leaching after 10 min of sonication. Both MSP and MS-C showed excellent biocompatibility in cytotoxicity tests of L-929 cells. Finally, the practical hemostatic effect of these mesoporous silica materials was preliminarily tested on the mouse tail truncation hemorrhage model, MS-C showed even shorter blood clotting time (86.00 s) and less blood loss (0.02 g) than that of MSP (172.30 s, 0.07 g), besides the less residue and a cleaner wound surface. It was probably that MS-C had great potential for emergency hemostasis applications.

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Data Availability

All data generated or analysed during this study are included in this manuscript.

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Funding

The authors gratefully acknowledge the support for this work from the Military Medical Innovation Project[20WQ045] and Technology Major Project Program[18ZXJMTG00070].

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Authors and Affiliations

  1. Institute of Medical Support Technology, Academy of Military Science, 300161, Tianjin, China

    Zhuoran Zhang, Tao Liu, Zenghua Qi, Fan Li, Kun Yang, Sheng Ding, Song Lin & Feng Tian

  2. Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, 300457, Tianjin, China

    Tao Liu

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  1. Zhuoran Zhang
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Contributions

Zhuoran Zhang: Conceptualization, Methodology, Writing-Original Draft, Investigation and Resources.

Tao Liu: Investigation and Data Curation.

Zenghua Qi: Data Curation and Visualization.

Fan Li: Validation and Writing-Review&Editing.

Kun Yang, Sheng Ding, Song Lin, Feng Tian: Supervision.

Corresponding author

Correspondence to Fan Li.

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The animal experiment in this manuscript has passed ethical review, and the approval number is YSY-DWLL-2021018..

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The animal experiment in this manuscript has passed ethical review, and the approval number is YSY-DWLL-2021018.

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Zhang, Z., Liu, T., Qi, Z. et al. Fabrication of effective mesoporous silica materials for emergency hemostasis application. Silicon 14, 10521–10534 (2022). https://doi.org/10.1007/s12633-021-01648-6

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  • DOI: https://doi.org/10.1007/s12633-021-01648-6

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