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Synthesizing and Characterizing of Gelatin-Chitosan-Bioactive Glass (58s) Scaffolds for Bone Tissue Engineering

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Abstract

Nowadays repairing and regenerating of lost or damaged tissue still remain an important challenge in clinical techniques. Due to the variety of available bone grafts, different types of biodegradable materials are being utilized as a scaffold implant. The basic structure of the bone is an excellent natural composite which contains varieties of polymers and ceramics; therefore, it is important to manufacture a bone scaffold featuring sufficient mechanical strength, a good degree of biocompatibility, biodegradation and an increased rate of formation of new tissue. Bioactive glass has an appealing characteristic which can be utilized for repairing purposes as well as to cause a rapid response from the bone graft. In this study, a composite scaffold based on polymer matrix (gelatin-chitosan) and bioactive glass 58s was synthesized in the laboratory. Five samples of polymer scaffold with different proportions of bioactive glass were designed and investigated. The scaffolds were dried with freeze dryer, and a spongy structure was generated. The composite survey was carried out through FTIR technique to examine the crystallization of the structure, XRD to examine the morphology of the porosities, and SEM to examine the size of porosities and formation of apatite. This study reveals that the size of porosities is about 170–320 μm, which is suitable for angiogenesis and cell growth in the bone. The combination of enhanced properties and the formation of apatite on the surface of the scaffolds make them an ideal option as a bone substitute.

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Authors and Affiliations

  1. Biomaterials Group, Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

    Zarrin Ahmadi & F. Moztarzadeh

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  1. Zarrin Ahmadi
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  2. F. Moztarzadeh
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Correspondence to Zarrin Ahmadi.

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Ahmadi, Z., Moztarzadeh, F. Synthesizing and Characterizing of Gelatin-Chitosan-Bioactive Glass (58s) Scaffolds for Bone Tissue Engineering. Silicon 10, 1393–1402 (2018). https://doi.org/10.1007/s12633-017-9616-z

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