, Volume 2, Issue 1, pp 33–39 | Cite as

Synthesis of Enzyme and Quantum Dot in Silica by Combining Continuous Flow and Bioinspired Routes

  • Siddharth V. PatwardhanEmail author
  • Carole C. Perry
Original Paper


In this contribution, we demonstrate the potential of combining bioinspired synthesis and continuous flow processing to generate functional materials with possible applications in catalysis, biocatalysis and photonic devices. Specifically, we have prepared invertase immobilized on silica while preserving its enzymatic activity. Furthermore, we present routes to synthesize silica and gold colloid composite materials (Au@SiO2) and demonstrate that the colloids retain their optical activity.


Biomimetic Flow chemistry Enzymes Green chemistry 


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We thank the University of Strathclyde for Faculty of Engineering Scholarship, Research Support Fund and the US AFOSR (grant code FA9500-06-1-0154) for financial support. We also thank Dr. D. Belton, Dr. A. Rai, and Dr. A. Prabhune (National Chemical Laboratory, Pune) for their help in the flow apparatus set-up, experiments with Au NPs and invertase assay respectively.

Supporting Information Available

SEM of materials produced using PEHA at short residence time; EDXA and TGA data for invertase-silica composites.

Supplementary material

12633_2010_9038_MOESM1_ESM.pdf (176 kb)
Esm 1 (PDF 176 kb)


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Copyright information

© Springer Science & Business Media BV 2010

Authors and Affiliations

  1. 1.Department of Chemical and Process EngineeringUniversity of StrathclydeGlasgowUK
  2. 2.School of Science and TechnologyNottingham Trent UniversityNottinghamUK

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