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Autologes Lipofilling

Ein fester Bestandteil der plastisch-rekonstruktiven und ästhetischen Chirurgie

Autologous lipofilling

An integral part of plastic, reconstructive, and aesthetic surgery

  • Leitthema
  • Published:
Journal für Ästhetische Chirurgie Aims and scope

Zusammenfassung

Die freie Fettgewebstransplantation findet breite klinische Anwendung, wobei die Indikationen von rekonstruktiven Eingriffen nach Operationen, Narbentherapie oder Thoraxdeformitäten bis zu ästhetischen Korrekturen reichen. Bei etwa 1% der im Fettgewebe vorkommenden Zellen handelt es sich um adulte Stammzellen, welche über hohe Differenzierungsmöglichkeiten verfügen und sich deshalb für den Einsatz in verschiedenen chirurgischen Bereichen und insbesondere für das Lipofilling besonders eignen. Diskutiert wird der Einfluss auf die Angiogenese und auf Tumorzellen, der u. a. durch die von den adulten Stammzellen freigesetzten Wachstumsfaktoren und Zytokine ausgeübt wird. Der Einsatz des Lipofillings erscheint bei Patienten ohne Tumoranamnese sicher. Bei Tumorpatienten sollte ein Lipofilling erst nach kompletter Resektion (z. B. bei Brustkrebs) bzw. völliger Remission erfolgen.

Abstract

Free fatty tissue transplantation has broad clinical application, with indications ranging from reconstructive interventions following surgery, scar treatment, and chest deformities to aesthetic corrective surgery. Approximately 1% of fatty tissue cells are adult stem cells, which are highly inclined to differentiation, thereby making them particularly well suited for use in a variety of surgical settings, lipofilling in particular. The effect, triggered for example by growth factors and cytokines released by adult stem cells, this method has on angiogenesis and tumor cells is a topic of discussion. The use of lipofilling appears to be safe in patients with no history of cancer. Lipofilling in cancer patients should only be performed following full resection (e.g., for breast cancer) or total remission.

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  1. Klinik für Plastische Chirurgie, Hand- und Verbrennungschirurgie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    J. Kauczok, C. Opländer & N. Pallua

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  1. J. Kauczok
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  2. C. Opländer
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  3. N. Pallua
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Correspondence to J. Kauczok.

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Kauczok, J., Opländer, C. & Pallua, N. Autologes Lipofilling. J. f. Ästhet. Chirurgie 5, 125–130 (2012). https://doi.org/10.1007/s12631-012-0186-z

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  • DOI: https://doi.org/10.1007/s12631-012-0186-z

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