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Comment on: The fragility index of randomized controlled trials in pediatric anesthesiology

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References

  1. Hayes J, Zuercher M, Gai N, Chowdhury AR, Aoyama K. The fragility index of randomized controlled trials in pediatric anesthesiology. Can J Anesth 2023; 70: 1449–60. https://doi.org/10.1007/s12630-023-02513-3

    Article  PubMed  Google Scholar 

  2. Matics TJ, Khan N, Jani P, Kane JM. The fragility index in a cohort of pediatric randomized controlled trials. J Clin Med 2017; 14: 79. https://doi.org/10.3390/jcm6080079

    Article  CAS  Google Scholar 

  3. Schröder A, Muensterer O, von Sochaczewski CO. Paediatric surgical trials, their fragility index, and why to avoid using it to evaluate results. Pediatr Surg Int 2022; 38: 1057–66. https://doi.org/10.1007/s00383-022-05133-y

    Article  PubMed  PubMed Central  Google Scholar 

  4. Carter RE, McKie PM, Storlie CB. The fragility index: a P value in sheep’s clothing? Eur Heat J 2017; 38: 346–8. https://doi.org/10.1093/eurheartj/ehw495

    Article  Google Scholar 

  5. Waters P IV, Rucker B, Love M, Vassar M. Lowering the statistical significance threshold of randomized controlled trials in three major general anesthesiology journals. Can J Anesth 2023; 70: 1441–8. https://doi.org/10.1007/s12630-023-02529-9

    Article  PubMed  Google Scholar 

  6. Ho AK. The fragility index for assessing the robustness of the statistically significant results of experimental clinical studies. J Gen Int Med 2022; 37: 206–11. https://doi.org/10.1007/s11606-021-06999-9

    Article  Google Scholar 

  7. Bomze D, Asher N, Ali OH, et al. Survival-inferred fragility index of phase 2 clinical trials evaluating immune checkpoint inhibitors. JAMA Netw Open 2020; 3: e2017675. https://doi.org/10.1001/jamanetworkopen.2020.17675

    Article  PubMed  PubMed Central  Google Scholar 

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Disclosures

The authors declare no competing interests.

Funding statement

This work did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Support was provided solely by departmental and institutional resources.

Editorial responsibility

This submission was handled by Dr. Stephan K. W. Schwarz, Editor-in-Chief, Canadian Journal of Anesthesia/Journal canadien d’anesthésie.

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Authors and Affiliations

  1. Department of Anesthesiology and Perioperative Medicine, Queen’s University, Kingston, ON, Canada

    Anthony M.-H. Ho MD, FRCPC, FCCP, Jordan Leitch MD, FRCPC, Tarit Saha MBBS, FRCPC & Glenio B. Mizubuti MD, MSc, FRCPC

  2. Department of Pediatrics, Kingston General Hospital, Queen’s University, Kingston, ON, Canada

    Anupam Sehgal MD, DNB

Authors
  1. Anthony M.-H. Ho MD, FRCPC, FCCP
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  2. Anupam Sehgal MD, DNB
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  3. Jordan Leitch MD, FRCPC
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  4. Tarit Saha MBBS, FRCPC
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  5. Glenio B. Mizubuti MD, MSc, FRCPC
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Corresponding author

Correspondence to Glenio B. Mizubuti MD, MSc, FRCPC.

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This letter is accompanied by a reply. Please see Can J Anesth 2024; https://doi.org/10.1007/s12630-023-02659-0.

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Ho, A.MH., Sehgal, A., Leitch, J. et al. Comment on: The fragility index of randomized controlled trials in pediatric anesthesiology. Can J Anesth/J Can Anesth 71, 163–164 (2024). https://doi.org/10.1007/s12630-023-02658-1

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  • DOI: https://doi.org/10.1007/s12630-023-02658-1

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