The addition of epidural local anesthetic to systemic multimodal analgesia following lumbar spinal fusion: a randomized controlled trial

  • Stephen Choi
  • Y. Raja Rampersaud
  • Vincent W. S. Chan
  • Oma Persaud
  • Arkadiy Koshkin
  • Paul Tumber
  • Richard BrullEmail author
Reports of Original Investigations



This randomized trial aimed to evaluate the effects of adding continuous epidural analgesia with a bupivacaine and hydromorphone solution to systemic multimodal analgesia following one- or two-level lumbar spinal fusion.


Thirty-nine patients undergoing lumbar spinal fusion, stratified for sex and one- or two-level fusion, were randomized to receive a continuous postoperative epidural infusion of either 0.1% bupivacaine with 15 μg·mL−1 hydromorphone (LA group) or 0.9% saline (NS group) at 6 mL·hr−1 for 48 hr through an epidural catheter placed intraoperatively. All patients received a standardized postoperative multimodal analgesia regimen. Patients, healthcare providers, and research staff were blinded. The primary outcome measure was cumulative opioid consumption (oral morphine equivalent) during the first 48 hr postoperatively.


The mean (SD) cumulative opioid consumption 48 hours postoperatively was 249.3 (143.3) mg in the NS group and 184.7 (208.1) mg in the LA group (mean difference 64.6 mg; 95% confidence interval −54.3 to 183.5; P = 0.27). There were no adverse events in either group.


Continuous epidural infusion combined with systemic multimodal analgesia resulted in a mean reduction in 48-hr cumulative opioid consumption of 64.6 mg (95% confidence interval −54.3 to 183.5) following one- or two-level lumbar spinal fusion. This estimate of effect is imprecise, and the routine use of continuous epidural analgesia in this surgical population is not yet warranted. This trial was registered at NCT00644111.


Epidural Analgesia Hydromorphone Transforaminal Lumbar Interbody Fusion Opioid Consumption Epidural Infusion 
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L’ajout d’un anesthésique local en péridural à une analgésie multimodale systémique après une fusion lombaire: une étude randomisée contrôlée



Cette étude randomisée avait pour but d’évaluer les effets de l’adjonction d’une analgésie péridurale continue avec une solution de bupivacaïne et d’hydromorphone à une analgésie multimodale systémique après une fusion lombaire à un ou deux niveaux.


Trente-neuf patients subissant une fusion lombaire, stratifiés selon leur sexe et leur fusion lombaire (à un ou deux niveaux), ont été randomisés à recevoir une perfusion péridurale postopératoire continue avec soit 0,1 % de bupivacaïne et 15 μg·mL−1 d’hydromorphone (groupe LA) ou 0,9 % de normal salin (groupe NS) à 6 mL·h−1 via un cathéter péridural placé en période peropératoire. Tous les patients ont reçu un régime d’analgésie multimodale postopératoire standardisé. Les patients, les professionnels de la santé et le personnel de recherche étaient tous en aveugle. La principale mesure d’évaluation était la consommation cumulative d’opioïdes (équivalent morphine orale) pendant les premières 48 h postopératoires.


La consommation cumulée moyenne (ÉT) d’opioïdes à 48 h postopératoires était de 249,3 (143,3) mg dans le groupe NS et de 184,7 (208,1) mg dans le groupe LA (différence moyenne 64,6 mg; intervalle de confiance 95 % −54,3 à 183,5; P = 0,27). Aucun effet secondaire néfaste n’a été observé dans les deux groupes.


La combinaison d’une perfusion péridurale continue à une analgésie multimodale systémique a entraîné une réduction moyenne de la consommation cumulative d’opioïdes pendant les 48 h suivant l’opération de 64,6 mg (intervalle de confiance 95 % −54,3 à 183,5) suivant une fusion lombaire à un ou deux niveaux. L’estimation de l’effet est imprécise, et l’utilisation de routine d’une analgésie péridurale continue chez cette population chirurgicale n’est pas encore justifiée. Cette étude a été enregistrée au NCT00644111.



The authors sincerely thank Mr. Michael Yang (BSc) for his help with data collection.


PSI Foundation resident research grant (S.C. and R.B.); Toronto General and Western Hospital Foundation Educational Grant (Y.R.R. and O.P.); R.B. is supported by the Merit Award Program, Department of Anesthesia, University of Toronto.

Financial support

This project was supported by a Physicians’ Services Incorporated Resident Research Grant awarded to the first author (S.C., supervisor R.B. $19,500). Funding was also received from the Minimal Access Ambulatory Spine Surgery (MAASS) Research and Education Project, Toronto General and Western Hospital Foundation (Y.R.R., $6,000). The funding agencies had no role in protocol development, data collection/analysis, or preparation of the manuscript.

Conflicts of interest

None declared.


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Copyright information

© Canadian Anesthesiologists' Society 2014

Authors and Affiliations

  • Stephen Choi
    • 1
  • Y. Raja Rampersaud
    • 2
  • Vincent W. S. Chan
    • 3
  • Oma Persaud
    • 2
  • Arkadiy Koshkin
    • 3
  • Paul Tumber
    • 3
  • Richard Brull
    • 3
    Email author
  1. 1.Department of AnesthesiaSunnybrook Health Sciences CentreTorontoCanada
  2. 2.Division of Orthopedic Surgery, Toronto Western HospitalUniversity Health NetworkTorontoCanada
  3. 3.Department of Anesthesia and Pain ManagementToronto Western HospitalTorontoCanada

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