Intraoperative care
Perioperative pharmacology
Pharmacokinetic changes in severely obese patients are complex, and accurate dosing is a huge challenge since much of our understanding of drug dosing and kinetics comes from data on non-obese patients. The potential for incorrect dosing is high due to the impact of increases in cardiac output, extracellular fluid volume, fat mass, and lean body weight (LBW) on pharmacokinetics.64,65 The increase in LBW is counterintuitive. Although the ratio of LBW to total body weight (TBW) is lower in the obese, the absolute value of LBW is higher than in non-obese subjects of the same sex and height. There is a risk of accumulation of lipid soluble drugs, and the peak plasma levels of some drugs may be reduced due to higher volumes of distribution. Even if adequate peak plasma concentrations are obtained, tissue levels may be inadequate, and this has significant implications for prophylactic antimicrobial therapy.
Selection of the correct weight to use for dosing calculations can be confusing - should we be using “ideal body weight” (IBW), “lean body weight”, or “total body weight” to calculate drug doses? In addition, staff may simply be unfamiliar with techniques used to calculate IBW or LBW. Over 98% of metabolic activity occurs within lean body mass, and anesthesiologists should ensure that they are using the more accurate formulae for calculating LBW that have been developed and work across a wider range of BMI.66 It is also essential that anesthesia departments provide evidence-based advice on prescribing in severe obesity along with tools to support calculation of LBW (software or paper-based nomograms). In Fig. 2, the relationship between TBW, BMI, and LBW is shown graphically. A detailed analysis of the literature on kinetics and dosing in obesity is beyond the scope of this article. Data are available to provide some guidance on appropriate dosing for common perioperative medications (Table 3).64,65,67-74 In Table 4, there is an outline of the calculation methods for the various dosing weights.
Table 3 Dosing weight scalars for common perioperative medications
Table 4 Body weight adjustment equations
In general, muscle relaxant drugs should be dosed on the basis of ideal body weight. The exception is succinylcholine, which should be dosed according to total (actual) body weight. Neuromuscular block reversal agents may be dosed appropriately based on total (actual) body weight. Induction agents and opioids should be dosed on the basis of lean body weight.
Vascular access
Poorly defined anatomical landmarks in the obese patient can make vascular access a challenge. Peripheral access may well be achievable even in the severely obese provided that conditions are optimized (e.g., proper lighting, encouraging venodilation through gentle tapping, a patient clinician) and remembering sites, e.g., the anterior forearm. Conventional central venous access is an option where peripheral cannulation fails repeatedly, although this too may be difficult with the internal jugular vein “hidden” below significant amounts of mobile soft tissue. Peripherally inserted central catheters may be helpful. The decision to insert a central venous catheter should be considered carefully. Patients with advanced disease and concomitant cardiac failure may decompensate if placed supine or head-down to facilitate line insertion. Even in the absence of cardiac failure, prolonged periods in the supine or head-down position can cause respiratory decompensation. In obese patients, it has been shown that the internal jugular vein overlaps the carotid artery to a greater extent than in non-obese patients, and this may increase the risk of inadvertent arterial puncture if landmark techniques are used. Importantly, the degree of overlap in obese patients is already significant with the head in a neutral position, but the overlap is increased further as the patient’s head is rotated to 60° (as it does in the non-obese patient, although to a lesser extent).
The use of ultrasound guidance for central venous catheter insertion may overcome vein location issues, lower the risk of arterial puncture, and reduce the time it takes for insertion as expertise increases. Ultrasound has been shown to aid in the safe placement of internal jugular lines,75 and it may also be used to guide peripheral venous access76 and arterial access. Not surprisingly, compared with non-obese patients, obesity can hinder the ultrasound view of the subclavian vein,77 and novices should not attempt unsupervised ultrasound-guided subclavian line insertion in this patient group.
Regardless of the technique used, anesthesiologists should resist the temptation to embark on a procedure in these high-risk patients with tenuous venous access. Additional time spent on this basic requirement will minimize the risk of loss of access and subsequent failure to rescue the patient from cardiovascular or other compromise.
Blood pressure monitoring
Severe obesity makes the use of noninvasive blood pressure monitoring more difficult, and it is imperative that an appropriately sized cuff be used. Even with the correct cuff in place, recording times can be prolonged, and rapid changes in blood pressure will be missed. Elective placement of an arterial cannula facilitates rapid recognition and response to hemodynamic changes and also allows for relevant blood sampling.
Upper gastrointestinal function and risk of aspiration of gastric contents
Elevated BMI is consistently associated with higher rates of gastroesophageal reflux disease (GERD), particularly in females where estrogen exposure is considered a factor.78 Combined with higher gastric volumes than the non-obese, this would appear to increase the risk of aspiration of gastric contents into the airways. Recent literature suggests that gastric emptying is not impaired in the obese and is not a primary player in aspiration risk.79 The increase in GERD occurs particularly in patients with elevated abdominal fat mass, and obesity is also associated with greater risk of hiatal hernia.80
The function of the esophageal sphincters under anesthesia has been investigated in a study of obese and non-obese patients.81 This study found that upper esophageal sphincter pressures did not differ between obese and non-obese patients during induction (they fell equally), but lower esophageal sphincter pressures fell more in the obese group after anesthesia, and the difference was statistically significant. The barrier pressure (lower esophageal pressure – gastric pressure), which is probably more relevant to anesthesia, was also significantly lower in obese patients, although it was always positive. The same group have also shown that the application of positive end-expiratory pressure (PEEP) during anesthesia increases the pressure in the esophagus, which may act as a barrier against regurgitation.82 It should be noted that the obese patients in these studies did not have active GERD, and although this work is reassuring with respect to the use of laryngeal mask airway devices in similar patients, this cannot be extrapolated to patients with GERD.
Prokinetics, H2 receptor antagonists, or proton pump inhibitors should be considered in an attempt to reduce the incidence and impact of aspiration. The use of rapid sequence induction of anesthesia with cricoid pressure, positioning the patient in the ramped position on pillows or a wedge, or techniques, such as awake fibreoptic intubation, may all help to minimize the risk of aspiration at induction. At the end of surgery, extubation should not be attempted until the patient is awake and responsive with adequate airway reflexes, and it is often performed with the patient ramped or sitting.
Airway management
Patients with obesity are more likely to suffer serious airway problems during anesthesia than non-obese patients, and this risk may be up to four times higher in patients with severe obesity.83 Airway management, particularly bag-mask ventilation and intubation, is challenging in this population, and experienced staff should always be involved. Tools for predicting a difficult airway have recently been compared in a clinical study and reported elsewhere.84 In addition to conventional direct laryngoscopy or flexible fibreoptic intubation (awake or asleep but spontaneously breathing), an increasing number of airway adjuncts are available to facilitate other techniques in these difficult settings. All of the studies referred to in this section relate to patients with obesity.
Video and optical laryngoscopes
Intubation using the Pentax AWS® (Pentax Medical Company, Montvale, NJ, USA) has been compared with intubation using a conventional MAC 4 blade,85 and success was similar. More data are available on the Glidescope® (Verathon Medical Inc., Bothell, WA, USA), including intubation times and success comparable with oral fibreoptic intubation under anesthesia,86 better views and reduced difficulty with intubation compared with the MAC 4 blade,87 and success in the awake intubation scenario − although the success rate on first attempt was only 54%, 12% required three attempts, and 4% were failures.88 Studies suggest that intubation times with these devices are longer than with conventional laryngoscopy in terms of statistical significance, although it is questionable whether the increase is clinically relevant. The Airtraq® (VYGON, Écouen, France) is an optical laryngoscope (the anesthesiologist places his eye to the viewfinder) with an optional video system. It has shown shorter intubation times and lower intubation difficulty scores compared with a Macintosh laryngoscope.89 The authors commented on a non-significant increase in soft-tissue trauma with the Airtraq device. In another study the Airtraq device was compared with the CTrach® intubating laryngeal mask airway (see below) and the conventional Macintosh laryngoscope. Intubation times were shortest with the Airtraq, followed by the Macintosh, and the CTrach.90 In addition, more patients in the Airtraq and CTrach groups maintained oxygen saturation > 92%, and fewer patients in these groups desaturated to < 88%.
Intubation via a laryngeal mask airway (LMA™)
There are a number of LMAs designed as conduits for endotracheal intubation, and it certainly is likely that tracheal intubation with such devices will take longer in the obese patient than in the non-obese patient.91 In a recent randomized study the Intubating LMA airway (ILMA™) was compared with the LMA CTrach™, a modification allowing real-time visualization of the glottic opening during intubation (both LMA North America, San Diego, CA, USA), and the total intubation time was shorter in the ILMA group than in the LMA CTrach group.92 In this study, the LMA CTrach also required more manipulation to achieve a glottic view and ventilation. Taken together, the ILMA performed better in this evaluation. Even if ILMAs are not used for primary techniques, they are valuable in the setting of failed or difficult conventional intubation.
Conventional laryngeal mask airway devices
Not all obese patients require intubation, and laryngeal mask airways are appropriate tools where intubation can safely be avoided. The choice of device depends on local availability and individual patient fit. It has been suggested that devices without an inflatable cuff, such as the i-gel® supraglottic airway (Intersurgical Inc., Liverpool, NY, USA), provides for easier insertion and a better seal in lean individuals. In a recent comparison of the i-gel with the LMA Unique™ (LMA North America, San Diego, CA, USA) (a classic LMA with inflatable cuff) in obese patients with a BMI up to 35, the mean insertion time was found to be significantly shorter with the i-gel.93 In addition, the mean pressures at which leakage occurred were higher in the i-gel group than in the LMA Unique group, indicating a better seal.
Oxygenation and ventilation
Preoxygenation
The deleterious impact of obesity on lung volumes, compliance, and airway resistance are amplified under anesthesia. The fall in expiratory reserve volume and functional residual capacity (FRC) is a very important phenomenon for the anesthesiologist, since FRC is effectively the reservoir of oxygen that the body can draw on during periods of apnea. Severely obese patients suffer earlier (potentially precipitous) oxygen desaturation during periods of apnea, so it is critical to ensure that FRC is maintained during induction of anesthesia and that the available lung reserve is filled with as much oxygen as possible through the process of preoxygenation. Preoxygenation should occur with the patient positioned as upright as possible, e.g., in the sitting position, by placing the surgical table in a reverse Trendelenburg (head-up tilt) position, or by ramping the patient with linen/pillows or a purpose-built positioning device or wedge. It is prudent to optimize the process by avoiding sedation prior to preoxygenation and encouraging increased patient effort to achieve deep breaths. This will optimize the safe apnea time. Several positioning devices are available to help achieve the head-elevated laryngoscopy position (HELP), including the Rapid Airway Management Positioner (RAMP®, Airpal Inc, Center Valley, PA, USA), the Oxford Head Elevated Laryngoscopy Position (HELP) Pillow (ALMA Medical, Oxford, UK), and the Troop Elevation Pillow® (Sharn Anesthesia, Tampa, FL, USA). The goal with these devices is to achieve a position that is sufficiently elevated so that the sternum and external auditory meatus are level. In addition, these elevated positions may place greater strain on the patient’s arms and the brachial plexus; consequently, careful attention to limb support and padding is needed. The positioning devices may be sold with arm-boards etc. as accessories. Many modern operating tables will allow manipulation of body and leg portions to facilitate the beach-chair position, and this function can be used to advantage.
During preoxygenation, the FRC may be further augmented with the application of 5-10 cm H2O CPAP94 or with the use of NIV, e.g., an inspiratory pressure of 7-10 cm H2O above PEEP of 7 cm H2O. The addition of NIV is effective in reducing atelectasis formation, and a recent study again showed that both CPAP and NIV improve arterial oxygenation compared with conventional preoxygenation.95 In the same study, end-expiratory lung volumes may be further enhanced in some patients in the NIV group with the application of a recruitment maneuver following tracheal intubation, although the benefit was only seen in 12 of the 24 patients.
Positive end-expiratory pressure and lung recruitment maneuvers
It is important to ensure that the gains in end-expiratory lung volume achieved during preoxygenation with CPAP/NIV are not lost intraoperatively. Common sense would suggest the application of PEEP, and the addition of periodic recruitment maneuvers (repeated sustained lung inflation with peak pressures of 40 cm H2O have been used) or vital capacity maneuvers has been shown to improve oxygenation beyond the application of PEEP alone.96,97 These maneuvers should be followed by the application of PEEP to maintain recruitment. Positive end-expiratory pressure values of 10 cm H2O applied after recruitment/vital capacity maneuvers produce a lower A-a gradient than the application of zero PEEP (known as ZEEP) or 5 cm H2O PEEP in obese patients undergoing laparoscopic surgery.98 The degree of obesity, intraoperative positioning, and the nature of the surgery (laparoscopic surgery vs open) will dictate the frequency of these maneuvers, but repeated application is more effective than a single post-induction recruitment.99 There is no benefit to the use of high tidal volumes in an attempt to maintain FRC. It is important to bear in mind the impact that recruitment maneuvers and moderate to high levels of PEEP can have on hemodynamics by way of reducing venous return (right ventricular preload) and increasing right ventricular afterload and ultimately risking systemic hypotension.
Modes of ventilation
There is no convincing evidence to indicate superiority of one intraoperative ventilator mode over another in elective surgery in the severely obese. Volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) have been compared during laparoscopic gastric banding surgery in a randomized study of 24 obese patients.100 With a constant minute volume, there were no differences in airway pressures, oxygenation, or cardiovascular impact, but VCV resulted in a significantly lower arterial CO2 level (P < 0.01).
In contrast, in another study of 36 obese patients undergoing the same surgical procedure, results showed that, despite similar tidal volumes, minute volumes, and plateau pressures, the PCV group had lower PaCO2 [mean 39 (3.0) mmHg vs 40.5 (2.25) mmHg; P = 0.014], lower expired-arterial CO2 gradients [0.67 (0.27) vs 0.93 (0.27); P < 0.01], and better oxygenation [PaO2/F
i
O2 ratio 281 (107) mmHg vs 199 (74) mmHg; P = 0.011].101 There were no significant differences postoperatively in either study.
Patient positioning issues
There are three important aspects to patient positioning. First, appropriate positioning facilitates practical procedures, such as endotracheal intubation, RA, and central venous catheter insertion, in a way that optimizes the procedure and overcomes, or at least mitigates, associated physiological deterioration. Second, appropriate positioning reduces the risk of perioperative nerve, joint, and soft-tissue injury. Third, positioning for surgery often places the patients at a major physiological disadvantage that must be countered by the anesthesiologist. It will already be clear that positions involving elevation of the head of the bed (semi-recumbent, reverse Trendelenburg or beach-chair) are most favourable from the respiratory viewpoint,102 and these will not be discussed further in this section. This section does not cover all of the complications associated with each position but emphasizes those related to the pathophysiology of obesity.
Supine position
In the severely obese, this position is associated with significant reductions in lung volumes and increases in the work of breathing, which can precipitate hypoxemia. In addition, increased venous return and preload may place stress on the cardiovascular system, although in patients with very severe central obesity, venous return may actually be impeded through caval compression analogous to the effect of the gravid uterus, and aortic compression may occur. Critical cardiorespiratory instability can occur in morbidly obese patients. In 1979, this was reported by Tsueda et al. as “obesity supine death syndrome”.103 Lateral tilt may be required to offset aorto-caval compression. It has also been shown that prolonged supine positioning in obese patients with OSA leads to an increase in neck circumference caused by fluid shifts from the legs, although in non-operative patients, this does not seem to worsen sleep apnea.104 The impact on severely obese patients who are subject to prolonged surgery in this position is unknown.
Prone position
The critical care literature has shown that prone ventilation improves gas exchange. There are very limited data on intraoperative effects in the obese population. A frequently cited paper from 1996 studied only ten consecutive patients with BMI 30-40 but showed an improvement in FRC, lung compliance, and oxygenation in the prone position compared with the supine position.105 Of importance, emphasis was placed on obtaining free abdominal movement, with weight taken on the chest wall and pelvis. The tidal volume used in the study would be considered high by today’s standards, i.e., 12 mL·kg−1, and PEEP was not mentioned. It is critical to ensure that the abdomen is free in the obese patient. Failure to do so not only will embarrass the respiratory system but also will increase intra-abdominal pressure and place abdominal organs at risk of malperfusion. Displacement of airway devices is obviously of even greater concern in the obese population in this position.
Lithotomy position
The lithotomy position leads to increased venous return and cardiac output, provided cardiac reserve is adequate. The increased excursion of the diaphragm into the chest due to pressure from abdominal contents further reduces FRC and puts oxygenation at risk. The chest wall compliance may be reduced by mobile superficial adipose tissue coming to rest on the chest wall. The obese patient is at higher risk of neurological injury and compartment syndrome if the legs are not properly positioned and padded. In addition, the practice of using shoulder bars to prevent the patient sliding down the operating table risks injury to the brachial plexus if not handled carefully. If anesthesia with spontaneous breathing is used, pressure support ventilation with PEEP will likely be needed. It should also be remembered that the endotracheal tube might move distally towards the right main bronchus in this position.
Trendelenburg position
The head-down position is associated with exaggerated hemodynamic and respiratory effects with auto-transfusion of blood from the lower limbs and significant decreases in lung volume and compliance. This position should be avoided in awake morbidly obese patients for all but the shortest time, although NIV may facilitate tolerance if necessary. The endotracheal tube may move distally towards the right main bronchus in this position.
Lateral position
Although the lateral position has the attraction of allowing the weight of the obese abdomen to be transmitted away from the diaphragm in most cases, prolonged lateral positioning can lead to vascular congestion and relative hypoventilation in the dependent lung. The use of wedges to facilitate positioning for renal surgery can lead to interference with aortic or caval flow.
Regional anesthesia in the obese patient
Regional anesthesia or neuraxial anesthesia may avoid the problems of general anesthesia altogether, contribute to reductions in opioid consumption, and lessen pain-related respiratory and mobility issues. The ability of the severely obese patient to undergo surgery under RA will depend to a large extent on the position the patient is required to adopt for the procedure.
Obesity is an independent risk factor for a failed RA procedure, with epidural, paravertebral, continuous supraclavicular, and superficial cervical blocks having the highest failure rates.106 These techniques can obviously be more anatomically challenging in the obese patient, and such patients also have less tolerance for potential adverse effects, such as excessive spread of local anesthetic leading to higher than expected spinal or epidural blocks. Given the difficulty with landmark identification, there has been a great deal of interest in ultrasound-guided RA. This raises obvious questions about training, expertise, and the potential to prolong procedure times. Even if ultrasound is used, the structures of interest may be deep, and a lower frequency probe may be required to achieve adequate penetration. This will come at the expense of image resolution. It takes time and experience to position the patient for block insertion so as to optimize anatomical landmarks and needle pathways while avoiding respiratory distress. Monitoring and skilled assistance is mandatory during block insertion in these patients. The clinical trial literature on RA in severe obesity is not extensive, and a selection is presented below.
Brachial plexus block
Franco et al. retrospectively analyzed data from their RA database of 455 nerve stimulator-guided supraclavicular blocks in obese patients, and they compared the data with 1,565 blocks in non-obese patients.107 They reported a 94.3% success rate in the obese group vs a 97.3% success rate in the non-obese group, with accidental paresthesia being more common in morbidly obese patients than in non-obese patients (9.6% vs 2.2%, respectively). When ultrasound guidance is used in expert hands, severe obesity does not markedly increase the time it takes to perform blocks (e.g., interscalene), and ultrasound guidance may help to improve block success.108
Nerve stimulator-guided blocks have the same impact on success rate. Hanouz et al. studied nerve stimulator-guided multiple injection axillary brachial plexus blocks and showed a 91% success rate in the obese group vs a 98% success rate in the non-obese group.109 Complications, such as inadvertent vascular puncture, were more common in the obese group than in the non-obese group (27% vs 9%, respectively).
With respect to interscalene block (ISB), the obvious concern is the significant (almost universal) incidence of phrenic nerve block leading to partial or complete diaphragmatic paralysis and exacerbating obesity-induced respiratory dysfunction. If ISB is required in a morbidly obese patient, it has been suggested that phrenic nerve involvement may be reduced by the use of ultrasound guidance, allowing the smallest volumes of local anesthetic to be administered, followed by a continuous low-volume infusion via catheter.110 Schwemmer et al. studied ultrasound-guided ISB in 70 patients who were a mix of obese and normal weight individuals.108 A high-frequency probe was used, and the authors found that nerve visualization in the obese group took 5 (1) min vs 4 (2) min in the normal weight group, unlikely to be clinically significant. There was no statistically significant difference in block success at 94% in the normal weight group and 77% in the obese group, most likely because of the small numbers involved. In an attempt to increase the available data, Schroeder et al. looked at retrospective data from 528 ultrasound-guided ISBs to determine if there was a relationship between obesity and block performance.111 They confirmed that increased BMI was associated with increased time for block placement as well as with pain scores and opioid consumption in the postanesthesia care unit (PACU). There is little doubt that brachial plexus block can be successful in morbidly obese patients, but these successes require expertise and experience that training programs must ensure they deliver.
Neuraxial anesthesia and analgesia
One obvious difficulty with neuraxial techniques in the morbidly obese is localization of the epidural or subarachnoid space through lack of tactile identification of spinous processes. Recently, there has been an upsurge of interest in the use of ultrasound to guide neuraxial blocks.112 Much of the work in this area has been in the obstetric population, although in an orthopedic population of patients with difficult anatomy (a mixture of obese patients and patients with scoliosis or previous lumbar spine surgery), ultrasound was shown to improve first attempt success rates, reduce needle insertion attempts and needle passes, and shorten the time to perform spinal anesthesia.113 The ultrasound estimated depth to the epidural space appears to correlate well with the actual needle distance, at least in obese parturients.114 Description of the ultrasound technique is beyond the scope of this article, and we refer readers to existing reviews on the topic.
Longer epidural and spinal needles will be required for some of these patients, and needle-through-needle techniques may assist to maintain needle trajectory when performing spinal anesthesia. Given the mass of subcutaneous fat and its relative mobility, one particular problem is dislodgement of the epidural catheter as the skin surface to epidural space distance changes when, for example, moving a patient from the lateral to the supine position or vice versa. With the insertion technique, a balance must be maintained between allowing additional catheter length to cope with space distance changes vs avoiding the risks of catheter malposition. Epidural catheter markings in some kits are provided in centimeters only up to 15 cm with the next marking at 20 cm. This may make recording an accurate insertion distance difficult in patients at extremes of obesity.
Epidural analgesia after surgery may be associated with improved respiratory function in the obese and a reduction in side effects from systemic opioids. Specifically, better recovery of vital capacity and spirometric values was seen in an observational study of 84 patients undergoing midline laparotomy for gynecological surgery.115 Unfortunately, only 16 patients in the study had a BMI > 30, and it appears the comparison group received methadone as required on a background of regular intravenous paracetamol. Consequently, this study may not represent the best comparator technique.
Trunk blocks
Even in abdominal surgery cases where neuraxial block is contraindicated or technically impossible, techniques such as transversus abdominis plane blocks or rectus sheath blocks can reduce pain and opioid consumption significantly. There is no doubt that these techniques are challenged by excessive adipose tissue, particularly catheter insertion and maintenance within the rectus sheath, but they are feasible even if poorly studied to date in morbidly obese patients.
Postoperative management
Emergence from anesthesia
Prior to tracheal extubation, patients should have full return of neuromuscular function, and they should be cooperative and alert with adequate spontaneous tidal volumes, especially if elective NIV is not planned following tracheal extubation. Careful attention must be paid to ensure adequate doses of reversal agent are used as postoperative residual curarization has the potential to precipitate a catastrophic decline in respiratory status and acid-base in the severely obese, even in the absence of OHS or overt OSA. Gaszynski et al. studied reversal of rocuronium-induced neuromuscular block with sugammadex 2 mg·kg−1 corrected body weight or neostigmine 50 μg corrected body weight in 70 morbidly obese patients.116 They showed that the time to achieve 90% train-of-four (TOF) ratio was significantly shorter in the sugammadex group than the neostigmine group at 2.7 vs 9.6 min, respectively (P < 0.05), and the TOF ratio in the PACU was 109.8% in the sugammadex group vs 85.5% in the neostigmine group (P < 0.05). Care should be taken to understand the dosing weight used when reading studies in this area. Van Lecker et al. studied 100 morbidly obese patients assigned randomly to one of four groups administered sugammadex: 2 mg·kg−1 ideal body weight, ideal body weight + 20%, ideal body weight + 40%, and actual body weight (69). The time from administration of sugammadex to TOF ratio > 90% was shortest in the IBW + 40% group at 112.5 sec, followed by actual body weight at 128.8 sec, which was not significantly different from the IBW + 40% group. The reversal time for IBW and IBW + 20% were significantly prolonged compared with IBW + 40% (P = 0.0001, and P = 0.003, respectively). Interestingly, the shorter time to reversal in the IBW + 40% group came with the administration of a smaller mean dose of sugammadex, 162.3 mg vs 236.5 mg; unfortunately, this outcome was not explained. There were no significant differences in tracheal extubation times or times to eye opening, and reversal was successful in all patients, with the authors recommending dosing based on IBW + 40%.
A number of case reports have shown that the use of sugammadex does not guarantee absence of the risk of recurarization. For example, Le Corre et al. reported a case of a 115-kg female who received a dose of sugammadex 1.74 mg·kg−1 actual body weight when she had return of two twitches. She subsequently achieved TOF ratio > 90% and required reintubation ten minutes later with loss of neuromuscular function necessitating a further dose of sugammadex.117
Careful attention should be paid to the correct use of neuromuscular monitoring equipment. This includes consideration of alternate monitoring locations (e.g., facial) in patients with very high levels of adipose at the wrist. A wrist circumference > 18 cm is associated with ulnar nerve supramaximal stimulation currents of over 70 mA, which monitoring devices may be unable to achieve.118
The obese patient should be positioned at least in the reverse Trendelenburg position and preferably in the semi-recumbent or sitting position as soon as is practical after the end of surgery. Tracheal extubation should occur in this position.
Optimization of lung function and oxygenation
Obese patients are at high risk for postoperative oxygen desaturation and ventilatory insufficiency. The effects of postoperative sedation or poorly controlled pain compound the reduced FRC, increased airway resistance, and reduced chest wall compliance mentioned earlier. Unfortunately, intermittent clinical observations may fail to detect even significant periods of desaturation, and continuous oxygen saturation monitoring is a useful and recommended tool. Many patients with severe obesity will suffer desaturation episodes of up to 30 min in duration, and it is important to note that these episodes are not eliminated by the use of supplemental oxygen alone.119,120 The need for postoperative oxygen supplementation remains one of the main barriers to day-case surgery for patients with obesity.121
Many patients with severe obesity and OSA will have their own CPAP machine, and the technique can be used successfully in the postoperative period, even in CPAP-naïve patients. Elective tracheal extubation to CPAP or NIV has been shown to improve postoperative oxygenation and offers flexibility where extubation to conventional facemask oxygen would not succeed.122 This technique can be utilized in the PACU, and the patient can then either electively remain on this therapy or have a trial of weaning over a period of hours. The evidence for use in patients who were not receiving such therapy preoperatively is tenuous, but this approach is logical given the additional physiological insults of surgery. Other options include intermittent NIV with interspersed periods of oxygen by facemask, which may be better tolerated by the patient. These techniques should be considered in individual patients based on operative site, impact on respiratory mechanics, and suspected risk of having OSA. Admission to step-down units facilitates closer monitoring during transition to baseline. There remains a need to train surgical floor staff to manage patients at high risk of respiratory complications, and support from specialist respiratory teams may be required for training and follow-up. Supplemental oxygen guided by clinical progress and monitoring results should be provided for at least the first 48-72 hr after major surgery. It should be remembered that these patients are at high risk until their normal sleep pattern is fully re-established, which may take three to four days or more. Patients with OHS require particularly careful management to balance their analgesic needs against their respiratory risks and to monitor their arterial blood gases for progress. Higher than necessary concentrations of inspired oxygen that achieve significantly supraphysiological PaO2 may result in increases in PaCO2 and reduced ventilatory drive in some OHS patients.123
Regardless of disposition following surgery, severely obese patients should be observed for evidence of increased work of breathing and decompensation, and increases in inspired oxygen fraction (F
i
O2) should be avoided without addressing underlying lung pathophysiology. Development of acute hypoxic or hypercapnic respiratory failure should prompt early and aggressive intervention, as rapid decompensation is likely otherwise.
Zoremba et al. carried out an interesting study looking at the utility of short-term respiratory physical therapy on lung function in 60 patients with BMI 30-40 undergoing minor peripheral surgery.124 The intervention was carried out in the PACU following tracheal extubation and consisted of repeated sets of incentive spirometry exercises every 15 min for the first two hours after surgery. The intervention group displayed better oxygen saturation in the PACU and at six and 24 hr postoperatively. There were also significant differences in favour of the intervention group in terms of forced expiratory volumes in one second, forced vital capacity, and peak expiratory flow lasting up to 24 hr. There are no data on the efficacy of similar interventions for more major surgery or in higher BMI groups, but this is certainly an area that should be studied further.
Pain control
Control of pain enables early mobilization and results in reducing the risk of pulmonary infections and venous thromboembolism. An opioid-sparing multimodal analgesia approach is used most often. This incorporates oral (or intravenous where available) paracetamol, nonsteroidal anti-inflammatory drugs (in the absence of contraindications), continuous peripheral nerve blocks, local anesthetic wound infiltration, or trunk blocks. Continuous wound infiltration techniques are also available.
If opioids are required, they should be used in the minimum effective dose. There are a number of options for adjunctive therapy to reduce analgesic requirements, with positive studies using preoperative central α-2 receptor agonists (e.g., clonidine and dexmedetomidine), pregabalin and gabapentin, and combined clonidine and S-ketamine.125-128 If opioid-based patient-controlled analgesia is to be used, background infusions should be avoided, and the lockout period should be adjusted to minimize sedation and respiratory depression.
Infection risk
Obesity is an independent risk factor for postoperative infectious complications.129 Patients with obesity are more likely to develop bloodstream infection, skin and soft-tissue infections, wound infections, wound dehiscence, urinary infections, and possibly pulmonary infections.130 This may relate to the combined effect of obesity-related immune dysfunction with altered tissue perfusion and perhaps inadequate antimicrobial dosing, but the effects of comorbidities, such as diabetes, should not be forgotten. Obesity and the accompanying chronic inflammatory state alter the number and function of dendritic epidermal T cells responsible for skin barrier functions and wound re-epithelialization, which results in less efficient wound healing.131 These cells also play a part in the regulation of wound site inflammation. Elevated FFA levels suppress T cell function and reduce the effectiveness of T-cell receptor signalling. Continuous exposure to elevated leptin levels in obesity diminishes the response of immune cells to the stimulating effect of this substance − they join other tissues and organs in becoming leptin resistant.132
How can this increased susceptibility to infection be countered? Aside from scrupulous attention to asepsis, perioperative antimicrobial administration should be timed carefully and drug doses should be considered properly to ensure adequate plasma and tissue levels. High-quality studies in this area are absent. Blood glucose control should be adequate throughout the perioperative period, and hospitals should have protocols in place to determine targets and treatment regimens.
Thromboembolic risk and prophylaxis
Obesity is an independent risk factor for venous thromboembolism (VTE), and many of these patients have lower limb venous stasis at baseline.133 Intraoperative use of appropriately sized mechanical devices, such as intermittent pneumatic compression devices, will also help to improve venous return as well as lower the risk of deep vein thrombosis. If a patient’s risk of bleeding is assessed as being low, pharmacological prophylaxis should be offered to all except those with ruptured cranial/spinal vascular malformations. The optimal prophylactic dose of low-molecular-weight heparin is unclear, although weight-based dosing is recommended in the obese patient over fixed doses.134 For example, it may be that a dose of enoxaparin up to 0.5 mg·kg−1 actual body weight (once or twice daily depending on VTE risk) is needed to achieve adequate anti-Xa levels.70,135 Anti-Xa monitoring may be beneficial in patients with very severe obesity, and target anti-Xa activity in the range of 0.2-0.4 IU·mL−1 has been recommended.136 Hospitals should ensure that their guidance is up-to-date and incorporates specific advice on management of the obese patient.
Mobilization
Early mobilization is a core target of enhanced recovery programs, and this should apply equally to the obese surgical patient. Mobilization will minimize respiratory complications, pressure-related skin damage, and venous thromboembolism. Epidural anesthesia should not be considered a barrier to mobilization, although patients should be supervised and an assessment of the presence of motor blockade should be made if local anesthetic infusions are used. Aggressive early mobilization may involve considerable manpower and resources. Patients should have clearly set and individualized daily mobilization targets. There should be objective triggers for patient review when mobilization targets are not met, as failure to mobilize may be an early sign of medical deterioration.
Nutrition support
Perioperative nutritional goals for severely obese patients include maintenance of euglycemia, provision of adequate protein and amino acid intake to minimize loss of muscle and optimize wound healing, and the provision of sufficient calories to permit utilization of endogenous fat stores without triggering severe ketoacidosis. For patients whose clinical course and surgery allow, return to oral intake in a staged manner is appropriate, starting with clear liquids and progressing through protein-enriched liquids back to diet. For patients who are ill or require critical care, more formal enteral or parenteral nutrition support may be required. High protein content hypocaloric feeding is one strategy that has been used successfully in the critically ill.137 Micronutrient deficiencies may require individual treatment schedules. The use of supplementation for vitamin and trace element deficiencies around bariatric surgery has recently been reviewed.138 Of particular importance for anesthesiologists is thiamine deficiency. This may present with neurological symptoms, which may be disregarded as minor side effects of regional or neuraxial anesthesia or may actually divert attention away from what is really a complication of regional or neuraxial anesthesia. In general, thiamine supplementation at 50 - 100 mg·day−1 is adequate, although higher doses will be required for Wernicke-Korsakoff syndrome.