Zusammenfassung
Das orale Plattenepithelkarzinom stellt eine weltweit relevante Erkrankung dar, die trotz des medizinischen Fortschritts weiter an Bedeutung gewinnt. Die Überlebensraten konnten während der letzten Jahrzehnte nicht deutlich gesteigert werden. Die Berücksichtigung der individuellen Prognosefaktoren und biologischen Merkmale des Tumors könnte der Schlüssel zur individuell optimierten Therapie sein, um sowohl das Überleben als auch die Lebensqualität für Patienten mit oralem Plattenepithelkarzinom zu verbessern. Neben den patientenindividuellen und tumorspezifischen Prognosefaktoren ist auch die Therapieentscheidung bedeutsam. Zur Heilung werden die aktuellen Therapieoptionen und zur Rehabilitation die Möglichkeiten der chirurgischen Rekonstruktion beschrieben. Hierzu stehen konventionelle oder mikrochirurgische Techniken unter Transplantation eines Fernlappens mit eigenem Gefäßanschluss zur Verfügung. Die dentale Implantologie ermöglicht auch bei Mundtrockenheit und großen Resektionsdefekten eine prothetische Rehabilitation. Dank der computergestützten Planung lassen sich dentale Implantate präzise inserieren.
Literatur
Massano J, Regateiro FS, Januario G, Ferreira A (2006) Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:67–76
Conway DI, Stockton DL, Warnakulasuriya KA et al (2006) Incidence of oral and oropharyngeal cancer in United Kingdom (1990–1999) – recent trends and regional variation. Oral Oncol 42:586–592
Shaw RJ, Pace-Balzan A, Butterworth C (2000) Contemporary clinical management of oral squamous cell carcinoma. Periodontol 57:89–101
La Vecchia C, Lucchini F, Negri E, Levi F (2004) Trends in oral cancer mortality in Europe. Oral Oncol 40:433–439
Hall SF, Groome PA, Rothwell D (2000) The impact of comorbidity on the survival of patients with squamous cell carcinoma of the head and neck. Head Neck 22:317–322
Preciado DA, Matas A, Adams GL (2002) Squamous cell carcinoma of the head and neck in solid organ transplant recipients. Head Neck 24:319–325
Day GL, Blot WJ, Shore RE et al (1994) Second cancers following oral and pharyngeal cancers: role of tobacco and alcohol. J Natl Cancer Inst 86:131–137
Silverman S Jr, Gorsky M, Greenspan D (1983) Tobacco usage in patients with head and neck carcinomas: a follow-up study on habit changes and second primary oral/oropharyngeal cancers. J Am Dent Assoc 106:33–35
Deleyiannis FW, Thomas DB, Vaughan TL, Davis S (1996) Alcoholism: independent predictor of survival in patients with head and neck cancer. J Natl Cancer Inst 88:542–549
Shingaki S, Takada M, Sasai K et al (2003) Impact of lymph node metastasis on the pattern of failure and survival in oral carcinomas. Am J Surg 185:278–284
Haddadin KJ, Soutar DS, Webster MH et al (2000) Natural history and patterns of recurrence of tongue tumours. Br J Plast Surg 53:279–285
Hughes CJ, Gallo O, Spiro RH, Shah JP (1993) Management of occult neck metastases in oral cavity squamous carcinoma. Am J Surg 166:380–383
O-charoenrat P, Pillai G, Patel S et al (2003) Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer. Oral Oncol 39:386–390
Woolgar JA, Rogers SN, Lowe D et al (2003) Cervical lymph node metastasis in oral cancer: the importance of even microscopic extracapsular spread. Oral Oncol 39:130–137
Shaw RJ, Lowe D, Woolgar JA et al (2010) Extracapsular spread in oral squamous cell carcinoma. Head Neck 32:714–722
Schliephake H (2003) Prognostic relevance of molecular markers of oral cancer–a review. Int J Oral Maxillofac Surg 32:233–245
Hartwig S, Syrjanen S, Dominiak-Felden G et al (2012) Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review. BMC Cancer 12:30
Syrjanen S (2010) The role of human papillomavirus infection in head and neck cancers. Ann Oncol 21(Suppl 7):vii243–245
Schwartz SR, Yueh B, McDougall JK et al (2001) Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study. Otolaryngol Head Neck Surg 125:1–9
Robertson AG, Soutar DS, Paul J et al (1998) Early closure of a randomized trial: surgery and postoperative radiotherapy versus radiotherapy in the management of intra-oral tumours. Clin Oncol (R Coll Radiol) 10:155–160
Nutting CM, Morden JP, Harrington KJ et al (2011) Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 12:127–136
Sutton DN, Brown JS, Rogers SN et al (2003) The prognostic implications of the surgical margin in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 32:30–34
Ferlito A, Rinaldo A, Robbins KT et al (2003) Changing concepts in the surgical management of the cervical node metastasis. Oral Oncol 39:429–435
Baujat B, Bourhis J, Blanchard P et al (2010) Hyperfractionated or accelerated radiotherapy for head and neck cancer. Cochrane Database Syst Rev:CD002026
Bourhis J, Overgaard J, Audry H et al (2006) Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet 368:843–854
Furness S, Glenny AM, Worthington HV et al (2010) Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy. Cochrane Database Syst Rev:CD006386
Glenny AM, Furness S, Worthington HV et al (2010) Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy. Cochrane Database Syst Rev:CD006387
Snietura M, Piglowski W, Jaworska M et al (2011) Impact of HPV infection on the clinical outcome of p-CAIR trial in head and neck cancer. Eur Arch Otorhinolaryngol 268:721–726
Ruwali M, Singh M, Pant MC, Parmar D (2011) Polymorphism in glutathione S-transferases: susceptibility and treatment outcome for head and neck cancer. Xenobiotica 41:1122–1130
Kissun D, Magennis P, Lowe D et al (2006) Timing and presentation of recurrent oral and oropharyngeal squamous cell carcinoma and awareness in the outpatient clinic. Br J Oral Maxillofac Surg 44:371–376
Pace-Balzan A, Shaw RJ, Butterworth C (2000) Oral rehabilitation following treatment for oral cancer. Periodontol 57:102–117
Shin YS, Koh YW, Kim SH et al (2012) Radiotherapy deteriorates postoperative functional outcome after partial glossectomy with free flap reconstruction. J Oral Maxillofac Surg 70:216–220
Rosenthal DI, Lewin JS, Eisbruch A (2006) Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol 24:2636–2643
Furness S, Worthington HV, Bryan G et al (2011) Interventions for the management of dry mouth: topical therapies. Cochrane Database Syst Rev 12:CD008934
Epstein JB, Hong C, Logan RM et al (2010) A systematic review of orofacial pain in patients receiving cancer therapy. Support Care Cancer 18:1023–1031
Worthington HV, Clarkson JE, Bryan G et al (2006) Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev:CD000978
Netscher DT, Meade RA, Goodman CM et al (2000) Quality of life and disease-specific functional status following microvascular reconstruction for advanced (T3 and T4) oropharyngeal cancers. Plast Reconstr Surg 105:1628–1634
Ueyama Y, Naitoh R, Yamagata A, Matsumura T (1996) Analysis of reconstruction of mandibular defects using single stainless steel A-O reconstruction plates. J Oral Maxillofac Surg 54:858–862
Kim MR, Donoff RB (1992) Critical analysis of mandibular reconstruction using AO reconstruction plates. J Oral Maxillofac Surg 50:1152–1157
Potter JK, Dierks EJ (2008) Vascularized options for reconstruction of the mandibular condyle. Semin Plast Surg 22:156–160
Mariani PB, Kowalski LP, Magrin J (2006) Reconstruction of large defects postmandibulectomy for oral cancer using plates and myocutaneous flaps: a long-term follow-up. Int J Oral Maxillofac Surg 35:427–432
August M, Tompach P, Chang Y, Kaban L (2000) Factors influencing the long-term outcome of mandibular reconstruction. J Oral Maxillofac Surg 58:731–737
Pogrel MA, Podlesh S, Anthony JP, Alexander J (1997) A comparison of vascularized and nonvascularized bone grafts for reconstruction of mandibular continuity defects. J Oral Maxillofac Surg 55:1200–1206
Foster RD, Anthony JP, Sharma A, Pogrel MA (1999) Vascularized bone flaps versus nonvascularized bone grafts for mandibular reconstruction: an outcome analysis of primary bony union and endosseous implant success. Head Neck 21:66–71
Nelson K, Heberer S, Glatzer C (2007) Survival analysis and clinical evaluation of implant-retained prostheses in oral cancer resection patients over a mean follow-up period of 10 years. J Prosthet Dent 98:405–410
Smolka K, Kraehenbuehl M, Eggensperger N et al (2008) Fibula free flap reconstruction of the mandible in cancer patients: evaluation of a combined surgical and prosthodontic treatment concept. Oral Oncol 44:571–581
Brown JS, Shaw RJ (2010) Reconstruction of the maxilla and midface: introducing a new classification. Lancet Oncol 11:1001–1008
Bohle GC, Mitcherling WW, Mitcherling JJ et al (2008) Immediate obturator stabilization using mini dental implants. J Prosthodont 17:482–486
Urken ML, Buchbinder D, Weinberg H et al (1989) Primary placement of osseointegrated implants in microvascular mandibular reconstruction. Otolaryngol Head Neck Surg 101:56–73
Sclaroff A, Haughey B, Gay WD, Paniello R (1994) Immediate mandibular reconstruction and placement of dental implants. At the time of ablative surgery. Oral Surg Oral Med Oral Pathol 78:711–717
Rohner D, Jaquiery C, Kunz C et al (2003) Maxillofacial reconstruction with prefabricated osseous free flaps: a 3-year experience with 24 patients. Plast Reconstr Surg 112:748–757
Interessenkonflikt
Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Koch, F. Leben und Überleben mit Mundkrebs. DFZ 56, 68–77 (2012). https://doi.org/10.1007/s12614-012-1280-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12614-012-1280-5