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Infections à Clostridium difficile en gériatrie

Clostridium difficile in geriatrics

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Les cahiers de l'année gérontologique

Résumé

Clostridium difficile est la première cause de diarrhée associée aux soins (post-antibiotique ou nosocomiale). L’incidence des infections à C. difficile (ICD) augmente, alors que le taux de réponse au métronidazole semble diminuer. Les récidives après un premier traitement sont fréquentes (20 %). Ainsi, de nouvelles alternatives thérapeutiques émergent avec en particulier la fidaxomicine et la transplantation de microbiote fécal. Cette revue a pour but de résumer l’épidémiologie, les moyens diagnostiques et thérapeutiques des ICD.

Abstract

C. difficile infection (CDI) is the most common etiology of diarrhea related to health care (postantibiotic diarrhea or nosocomial). The incidence of CDI is increasing, whereas metronidazole activity seems to decrease. There are many recurrences after a first occurrence of CDI (20%). Thus, new therapeutic ways are emerging among fidaxomicin, a new antibiotic class, and fecal microbiota transplantation seem to be the most interesting. The aim of this review is to summarize the epidemiology, diagnostic and therapeutic resources for CDI.

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Author information

Authors and Affiliations

  1. CSGA, centre hospitalier Alès Cévennes, 811 avenue du Dr J Goubert, F-30100, Alès, France

    P. Rozier & T. Fraisse

  2. Pôle de gériatrie, centre hospitalo-universitaire La Milétrie, F-86021, Poitiers cedex, France

    M. Lauda, M. Priner & M. Paccalin

  3. Service de maladies infectieuses, centre hospitalier de Chambéry, BP 1125, F-73011, Chambéry, France

    E. Forestier

Authors
  1. P. Rozier
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  2. T. Fraisse
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  3. M. Lauda
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  4. M. Priner
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  5. E. Forestier
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  6. M. Paccalin
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Corresponding author

Correspondence to T. Fraisse.

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Rozier, P., Fraisse, T., Lauda, M. et al. Infections à Clostridium difficile en gériatrie. cah. année gerontol. 6, 107–113 (2014). https://doi.org/10.1007/s12612-014-0391-9

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  • DOI: https://doi.org/10.1007/s12612-014-0391-9

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