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Fragilité et infection chez le sujet âgé : quelles relations ?

Frailty and infection in the elderly: which relations?

  • Article de Synthèse / Review Article
  • Published:
Les cahiers de l'année gérontologique

Résumé

Les pathologies infectieuses sont plus fréquentes chez les sujets âgés. L’immunosénescence, le statut fonctionnel et la fragilité ont un rôle explicatif de ce sur-risque infectieux et influencent le pronostic au décours d’une infection. À l’inverse, une infection peut entraîner une altération du statut fonctionnel induisant au long cours un sur-risque infectieux. À partir des données de la littérature, nous explicitons le cercle vicieux qui relie fragilité et risque infectieux.

Abstract

Prevalence of infections is high in the elderly. Age-related changes in immunity, functional status and frailty might explain this prevalence. On the other hand, infections decrease the functional status that enhances the risk of infections. Through the literature data, we report this vicious circle that links frailty and infection.

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Authors and Affiliations

  1. Clinique universitaire de médecine gériatrique, Pôle pluridisciplinaire de médecine, Centre hospitalier universitaire A. Michallon, BP217, F-38043, Grenoble cedex 09, France

    S. Mazière & G. Gavazzi

  2. GREPI, TIMC-IMAG, CNRS UMR 5525, BP217, F-38043, Grenoble cedex 09, France

    G. Gavazzi

  3. Service de gériatrie, CHU la Milétrie, 2, rue de la Miletrie, BP 577, F-86021, Poitiers cedex, France

    M. Paccalin

Authors
  1. S. Mazière
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  2. G. Gavazzi
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  3. M. Paccalin
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Correspondence to M. Paccalin.

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Mazière, S., Gavazzi, G. & Paccalin, M. Fragilité et infection chez le sujet âgé : quelles relations ?. cah. année gerontol. 4, 17–20 (2012). https://doi.org/10.1007/s12612-012-0255-4

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  • DOI: https://doi.org/10.1007/s12612-012-0255-4

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