Basic and Clinical Andrology

, Volume 22, Issue 1, pp 20–28 | Cite as

Anticorps antispermatozoïdes : indications, étiologies et applications en 2011, de l’exploration de l’infertilité au concept d’immunocontraception masculine

Open Access
Revue / Review

Résumé

La présente revue de la littérature a pour but de préciser en 2011 les techniques utilisées pour le dépistage des anticorps antispermatozoïdes (ACAS) et l’intérêt de ce dépistage dans diverses situations physiopathologiques mais aussi dans le choix du traitement des infertilités par les techniques d’assistance médicale à la procréation (AMP). De plus, l’étude des cibles et du rôle des ACAS dans l’infertilité a permis la mise au point d’un vaccin contraceptif masculin efficace dans certains modèles animaux et potentiellement utilisable chez l’homme.

Mots clés

Anticorps antispermatozoïdes (ACAS) Implications cliniques Assistance médicale à la procréation (AMP) Infertilité immunologique Vaccination contraceptive 

Abréviations

ABCD

Agénésie bilatérale des canaux déférents

ACAS

Anticorps antispermatozoïdes

AMP

Assistance médicaleà la procréation

CRISP1

Cysteine rich secretory protein 1

EPPIN

Epididymal protease inhibitor

IBT

Immunobeads test

ICSI

Intracytoplasmic sperm injection

MAR

test, Mixed antiglobulin, reaction test

TESE

Testicular sperm extraction

Antisperm antibodies: screening and applications in 2011, from male inferility checkup to immunocontraceptive vaccine

Abstract

The present literature review aims at clarifying the techniques used in the screening of antisperm antibodies (ASAS), the value of screening at different physiological and pathological conditions, and the choice of infertility treatment in assisted reproduction. Moreover, studying the targets and the role of ASAS in infertility allowed for the development of antisperm contraceptive vaccines, which are found effective in some animal models and potentially usable in humans.

Keywords

Antisperm antibodies (ASAS) Clinical implications Assisted reproduction Immunologic infertility Antisperm contraceptive vaccines 

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Copyright information

© SALF et Springer-Verlag France 2012

Authors and Affiliations

  1. 1.Laboratoire TOPBIOTarbesFrance

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